DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nerfin-2 and Insm2

DIOPT Version :9

Sequence 1:	NP_001262446.1	Gene:	nerfin-2 / 41235	FlyBaseID:	FBgn0041105	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_064683.2	Gene:	Insm2 / 56856	MGIID:	1930787	Length:	493	Species:	Mus musculus

Alignment Length:	440	Identity:	120/440 - (27%)
Similarity:	168/440 - (38%)	Gaps:	142/440 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 ATAEIRTTSSDNLPPPPPPPPPPATSTIPATPPLPPPPISRPHKAERR----------RSKLRKH 397
            :.|....||.:.|.||          .:|.:.|:|.|. ..||..:||          .:.:||.
Mouse   106 SAAPAAVTSGEELVPP----------QVPVSVPIPVPG-PAPHGLQRRGKGAPVCASAPAAVRKP 159

  Fly   398 MAI------DEETISPVSGTIIRKLRDDEELVVRKGDIDPAFNVVEITEEAKAILASIDNKIGDY 456
            .|:      ||.|.|||.|.   |::::|          |.       ..|:| |..:...:|::
Mouse   160 KAVRRLSFADEVTTSPVLGL---KIKEEE----------PG-------APARA-LGGVRTPLGEF 203

  Fly   457 MCQLCRTVYDDAFMLAQHRCPRIVHIEYKCSECEKVFNCPANLASHRRWHKPK---AEAAGVNP- 517
            :||||:..|.|.|.||||||.|||.:||:|.||:|||:||||||||||||||:   |.||...|
Mouse   204 ICQLCKHQYADPFALAQHRCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRPTPACAASKPPH 268

  Fly   518 --------------AKKRVVETGDLVQEATRSGDD------------------------------ 538
                          ...||..|.|...:|..|..|
Mouse   269 APLTPPDPSLATGKENGRVPRTDDQHPQAPDSSGDGQHRDSAARPGLQALVYPEAARPQAPYPEV 333

  Fly   539 ---------------ASDGIYPCHICGKTFRRQAYLKKHQASHQMLDNLKNLDFFKSQQ-QQLTI 587
                           |:..::.|..|.|.|||||||:||..:|:..........|.|:: ..||.
Mouse   334 ILGRHGPGSSGASAGATSEVFVCPYCHKKFRRQAYLRKHLGTHETGSARAPTPGFGSERTAPLTF 398

  Fly   588 -----NGHQLADHVQLQHTTGQAVTSAAPYASLPRPPPGMPMYPPPSGKNYPGGQRFPGFPFQSF 647
                 ..|..:..::.:|....||.......:|    .|.|....|.|.:....|       |.|
Mouse   399 ACPLCGAHFPSADIREKHRLWHAVREELLLPAL----VGAPSEAGPGGASDGSAQ-------QIF 452

  Fly   648 DQRRFYSLGEFYLSQHLERSSAFQYVQANHLRQL--SNVAQTLMPPLPVK 695
            ..:  |....|:.|..|.|          |:.:.  |...|.|:..:|::
Mouse   453 SCK--YCPSTFFSSPGLTR----------HINKCHPSESRQVLLLQMPLR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nerfin-2	NP_001262446.1	C2H2 Zn finger	458..481	CDD:275368	15/22 (68%)
		C2H2 Zn finger	486..506	CDD:275368	16/19 (84%)
		zf-C2H2	544..566	CDD:278523	12/21 (57%)
		C2H2 Zn finger	546..566	CDD:275368	12/19 (63%)
Insm2	NP_064683.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		SNAG domain. /evidence=ECO:0000250	1..20
		Atrophin-1	<2..343	CDD:331285	80/268 (30%)
		C2H2 Zn finger	205..225	CDD:275368	13/19 (68%)
		C2H2 Zn finger	233..253	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..310		19/61 (31%)
		zf-C2H2	354..376	CDD:306579	12/21 (57%)
		C2H2 Zn finger	356..376	CDD:275368	12/19 (63%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	454..475	CDD:275368	6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3993
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002683
OrthoInspector	1	1.000	-	-		mtm8711
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15065
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3291
SonicParanoid	1	1.000	-	-		X1791
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.900