DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nerfin-2 and Insm1

DIOPT Version :9

Sequence 1:	NP_001262446.1	Gene:	nerfin-2 / 41235	FlyBaseID:	FBgn0041105	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_058585.2	Gene:	Insm1 / 53626	MGIID:	1859980	Length:	521	Species:	Mus musculus

Alignment Length:	414	Identity:	116/414 - (28%)
Similarity:	152/414 - (36%)	Gaps:	169/414 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 PPPPPPPPPPATSTIPATPPLPPPPISRPHKAERRRSKLRKHMAIDEETISPVSGTIIRKLRDDE 420
            ||...|.||.|.:|.|.......|...:| ||      :||....||.|.|||.|
Mouse   200 PPGKRPAPPAAVATEPPAKAAKAPSAKKP-KA------IRKLHFEDEVTTSPVLG---------- 247

  Fly   421 ELVVRKGDIDPAFNVVEITEEAKAILASIDNKIGDYMCQLCRTVYDDAFMLAQHRCPRIVHIEYK 485
             |.:::|.:          |..:.........:|:::||||:..|.|.|.||||:|.|||.:||:
Mouse   248 -LKIKEGPV----------EAPRGRAGGATRPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYR 301

  Fly   486 CSECEKVFNCPANLASHRRWHKPK-------------------AEAAGVNPAKKRVVETGDLVQE 531
            |.||.|||:||||||||||||||:                   .||||...:.:.....|.:
Mouse   302 CPECAKVFSCPANLASHRRWHKPRPVPAAARAPEPEAATRAEAREAAGGGSSDRDTPSPGGV--- 363

  Fly   532 ATRSGDDASDGIYPCHICGKTFRRQAYLKKHQASHQMLDNLKNLDFFKSQQQQLTINGHQLADHV 596
             :.||.:  ||:|.||.|.|.|||||||:||..:|                            |.
Mouse   364 -SESGSE--DGLYECHHCAKKFRRQAYLRKHLLAH----------------------------HQ 397

  Fly   597 QLQHTTGQAVTSAAPYASLPRPPPGMPMYPPPSGKN----YPG---------------------- 635
            .||       ...||    |.|||     |||..::    |.|
Mouse   398 ALQ-------AKGAP----PPPPP-----PPPPAEDILAFYAGPDEKAPQEASGDGEAAGVLGLS 446

  Fly   636 -----------GQRFPG----------------FPFQSFDQRRFYSLGEFYLSQHLERSSAFQYV 673
                       |:.||.                ||.:       |....||.|..|.|
Mouse   447 ATAQCHLCPVCGETFPSKGAQERHLRLLHAAQVFPCK-------YCPATFYSSPGLTR------- 497

  Fly   674 QANHLRQL--SNVAQTLMPPLPVK 695
               |:.:.  |...|.::..:||:
Mouse   498 ---HINKCHPSENRQVILLQVPVR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nerfin-2	NP_001262446.1	C2H2 Zn finger	458..481	CDD:275368	14/22 (64%)
		C2H2 Zn finger	486..506	CDD:275368	16/19 (84%)
		zf-C2H2	544..566	CDD:278523	14/21 (67%)
		C2H2 Zn finger	546..566	CDD:275368	13/19 (68%)
Insm1	NP_058585.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		SNAG domain. /evidence=ECO:0000305\|PubMed:24227653	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250\|UniProtKB:Q01101	2..7
		Necessary for interaction with CCND1. /evidence=ECO:0000250	43..56
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..230		10/30 (33%)
		C2H2 Zn finger	274..294	CDD:275368	12/19 (63%)
		C2H2 Zn finger	302..322	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..369		12/52 (23%)
		zf-C2H2	373..395	CDD:278523	14/21 (67%)
		C2H2 Zn finger	375..395	CDD:275368	13/19 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..419		11/36 (31%)
		C2H2 Zn finger	454..475	CDD:275368	3/20 (15%)
		C2H2 Zn finger	482..503	CDD:275368	7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3993
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002683
OrthoInspector	1	1.000	-	-		mtm8711
orthoMCL	1	0.900	-	-		OOG6_109400
Panther	1	1.100	-	-	O	PTHR15065
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3291
SonicParanoid	1	1.000	-	-		X1791
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.800