DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nerfin-2 and INSM1

DIOPT Version :9

Sequence 1:	NP_001262446.1	Gene:	nerfin-2 / 41235	FlyBaseID:	FBgn0041105	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_002187.1	Gene:	INSM1 / 3642	HGNCID:	6090	Length:	510	Species:	Homo sapiens

Alignment Length:	352	Identity:	112/352 - (31%)
Similarity:	141/352 - (40%)	Gaps:	97/352 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 PPPPPPPPPPATSTIPATPPLPPPPISRPHKA-----ERRRSKLRKHMAIDEETISPVSGTIIRK 415
            |.|.||.||.|....|...|.||.....|.||     .::...:||....||.|.|||.|
Human   183 PGPGPPLPPAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPVLG----- 242

  Fly   416 LRDDEELVVRKGDIDPAFNVVEITEEAKAILASIDNKIGDYMCQLCRTVYDDAFMLAQHRCPRIV 480
                  |.:::|.:          |..:.........:|:::||||:..|.|.|.||||:|.|||
Human   243 ------LKIKEGPV----------EAPRGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIV 291

  Fly   481 HIEYKCSECEKVFNCPANLASHRRWHKPKAEAAGVNPAKKRVVETGDLVQEATRSGDD------- 538
            .:||:|.||.|||:||||||||||||||:...|.....:.......: .:||...|.|
Human   292 RVEYRCPECAKVFSCPANLASHRRWHKPRPAPAAARAPEPEAAARAE-AREAPGGGSDRDTPSPG 355

  Fly   539 ------ASDGIYPCHICGKTFRRQAYLKKHQASHQMLDNLKNLDFFKSQQQQLTINGHQLADHVQ 597
                  :.||:|.||.|.|.|||||||:||..:|                            |..
Human   356 GVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAH----------------------------HQA 392

  Fly   598 LQHTTGQAVTSAAPYASLPRPPPG---MPMYPPPSGKNYPGGQRFPGFPFQSFDQRRFYSLG--- 656
            ||       ...||.|     ||.   :.:||.|..|   ..|...|      |......||
Human   393 LQ-------AKGAPLA-----PPAEDLLALYPGPDEK---APQEAAG------DGEGAGVLGLSA 436

  Fly   657 --EFYLSQHLERSSAFQYVQANHLRQL 681
              |.:|......|.|.:..|..|||.|
Human   437 SAECHLCPVCGESFASKGAQERHLRLL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nerfin-2	NP_001262446.1	C2H2 Zn finger	458..481	CDD:275368	14/22 (64%)
		C2H2 Zn finger	486..506	CDD:275368	16/19 (84%)
		zf-C2H2	544..566	CDD:278523	14/21 (67%)
		C2H2 Zn finger	546..566	CDD:275368	13/19 (68%)
INSM1	NP_002187.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..110
		SNAG domain. /evidence=ECO:0000250\|UniProtKB:Q63ZV0	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269\|PubMed:23721412	2..7
		Necessary for interaction with CCND1	43..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..226		14/42 (33%)
		C2H2 Zn finger	269..289	CDD:275368	12/19 (63%)
		C2H2 Zn finger	297..317	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..362		10/47 (21%)
		zf-C2H2	367..389	CDD:278523	14/21 (67%)
		C2H2 Zn finger	369..389	CDD:275368	13/19 (68%)
		C2H2 Zn finger	443..464	CDD:275368	7/21 (33%)
		C2H2 Zn finger	471..492	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3993
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002683
OrthoInspector	1	1.000	-	-		mtm8472
orthoMCL	1	0.900	-	-		OOG6_109400
Panther	1	1.100	-	-	O	PTHR15065
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3291
SonicParanoid	1	1.000	-	-		X1791
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.800