DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fancl and Fancl

DIOPT Version :9

Sequence 1:	NP_649974.1	Gene:	Fancl / 41231	FlyBaseID:	FBgn0037781	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_080199.1	Gene:	Fancl / 67030	MGIID:	1914280	Length:	375	Species:	Mus musculus

Alignment Length:	396	Identity:	94/396 - (23%)
Similarity:	155/396 - (39%)	Gaps:	58/396 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EDVERLLCQKYPGLAAELQPSGACIIRGVLGSEDTWRRLKLYLPHHPALHGFQLYVQESL----- 64
            ::.|..|.:.:|.|..  |.....:..|.:.::.:...|::.||....|...:|.....|
Mouse     2 DEAEASLLRHFPLLLP--QNREKTVYEGFISAQGSDFHLRIVLPKDLQLKKARLLCSLQLKNILN 64

  Fly    65 EYKLYTSANLKLQDDWLLEDFLDHLPKILPAQKAPTVPKELCRE--------------GNIYYDI 115
            ||.......:|...|  |..|:..|..||  :.|....:|||.:              |.|.:|.
Mouse    65 EYHQVVQQRMKHSPD--LMSFMMELKMIL--EVALKNKQELCVQPPSCSFCKDLLTEIGAIGWDK 125

  Fly   116 LALYKS--NEYCLQVDEACSMIRFSEFTDFEQHYLELKI-------PSLLLLDHSLPDCVSLGEM 171
            ||..:|  :...|:.|:|..          .:|.:.:|:       |...::|..:|..||
Mouse   126 LACVESSFSTIKLKADDASG----------RKHLITVKLKAKYPVEPPDCVVDFPVPFSVS---- 176

  Fly   172 LTKSAGNLEEALNLFRKLLEDLRPFYDNFMDIDELCHVLQPSPISSKHKTRLFPLKDRVYLKLTI 236
             .....:|.:..:.|...||.|:.|:|...:|||...||:|.........|...|...|.:.:.:
Mouse   177 -WTPQSSLVDVYSQFLVALETLKVFWDVMDEIDEKTWVLEPEKPPRSATARRIALGKNVSIAIEV 240

  Fly   237 ADPFACIASMSLKIIGPTEEVARLRHVLSDGLSNWDSEMNIHKNLLRMFDLCYFPMPDWSDGPKL 301
             ||...........:|.......|...||..:..||.|.::.:||..:.:: .||      ...:
Mouse   241 -DPRHPTMLPEFCFLGADHVTKPLGMKLSGSIHLWDPENSLLQNLKDVLEI-DFP------ARSI 297

  Fly   302 DEEDNEELRCNICFAYRLDGGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPF 366
            .||.:..:.|.||:|..|:|. :|...|:|.:|....|.:||.||.:.|...:....|.||.||:
Mouse   298 LEESDFSMDCGICYARHLNGA-IPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPY 361

  Fly   367 CKAKLS 372
            |...::
Mouse   362 CSKPIT 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancl	NP_649974.1	WD-3	20..293	CDD:286806	66/300 (22%)
Fancl	NP_649974.1	FANCL_C	307..376	CDD:288626	22/66 (33%)
Fancl	NP_080199.1	WD-3	15..295	CDD:286806	67/307 (22%)
		UBC-RWD region (URD). /evidence=ECO:0000250	104..294		45/212 (21%)
		FANCL_C	303..371	CDD:288626	22/67 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842823
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_KOG3268
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007502
OrthoInspector	1	1.000	-	-		oto94695
orthoMCL	1	0.900	-	-		OOG6_105411
Panther	1	1.100	-	-	LDO	PTHR13206
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5262
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730