DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fancl and FANCL

DIOPT Version :9

Sequence 1:	NP_649974.1	Gene:	Fancl / 41231	FlyBaseID:	FBgn0037781	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	XP_011531241.1	Gene:	FANCL / 55120	HGNCID:	20748	Length:	403	Species:	Homo sapiens

Alignment Length:	386	Identity:	90/386 - (23%)
Similarity:	155/386 - (40%)	Gaps:	65/386 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IIRGVLGSEDTWRRLKLYLPH---------------HPALHGFQLYVQESLEYK---LYTSANLK 75
            :..|.:.::.....|::.||.               ...|.|:...||:.:::.   :.....||
Human    24 VYEGFISAQGRDFHLRIVLPEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQHSPDLMSFMMELK 88

  Fly    76 LQDDWLLEDFLDHLPKILPAQKAPTVPKELCRE-GNIYYDILALYKSNEYCLQVDEACSMIRF-S 138
            :    |||..|.:..::......|.....|..| |.:.:|.|         :..|...|.|:. :
Human    89 M----LLEVALKNRQELYALPPPPQFYSSLIEEIGTLGWDKL---------VYADTCFSTIKLKA 140

  Fly   139 EFTDFEQHYLELKIPSL-------LLLDHSLPDCVS------------LGEMLTKSA---GNLEE 181
            |.....:|.:.||:.:.       ..:|..:|.|.|            ..:|..|.|   .:|..
Human   141 EDASGREHLITLKLKAKYPAESPDYFVDFPVPFCASWTPQVNSPQVTDQAKMDVKIAVLPSSLIS 205

  Fly   182 ALNLFRKLLEDLRPFYDNFMDIDELCHVLQPSPISSKHKTRLFPLKDRVYLKLTIADPFACIASM 246
            ..:.|...:|.|:.|:|...:|||...||:|.........|...|.:.|.:.:.: ||.......
Human   206 IYSQFLAAIESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEV-DPRHPTMLP 269

  Fly   247 SLKIIGPTEEVARLRHVLSDGLSNWDSEMNIHKNLLRMFDLCYFPMPDWSDGPKLDEEDNEELRC 311
            ....:|....|..|...||..:..||.|.::.:||..:.:: .||      ...:.|:.:..:.|
Human   270 ECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEI-DFP------ARAILEKSDFTMDC 327

  Fly   312 NICFAYRLDGGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLS 372
            .||:||:|| |.:|...|||::|....|.:||.||.:.|:..:....:.||:||:| :|:|
Human   328 GICYAYQLD-GTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNIIFGECPYC-SKVS 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancl	NP_649974.1	WD-3	20..293	CDD:286806	63/305 (21%)
Fancl	NP_649974.1	FANCL_C	307..376	CDD:288626	26/66 (39%)
FANCL	XP_011531241.1	WD-3	15..315	CDD:286806	63/311 (20%)
FANCL	XP_011531241.1	FANCL_C	323..384	CDD:288626	24/62 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152771
Domainoid	1	1.000	63	1.000	Domainoid score	I10316
eggNOG	1	0.900	-	-		E1_KOG3268
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I5176
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1002812at2759
OrthoFinder	1	1.000	-	-		FOG0007502
OrthoInspector	1	1.000	-	-		oto91110
orthoMCL	1	0.900	-	-		OOG6_105411
Panther	1	1.100	-	-	LDO	PTHR13206
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5262
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790