DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ohgt and crbn

DIOPT Version :9

Sequence 1:	NP_649973.1	Gene:	ohgt / 41230	FlyBaseID:	FBgn0037780	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001008192.1	Gene:	crbn / 493554	XenbaseID:	XB-GENE-973907	Length:	447	Species:	Xenopus tropicalis

Alignment Length:	493	Identity:	136/493 - (27%)
Similarity:	215/493 - (43%)	Gaps:	104/493 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 MVSQARNRDGGIAALLSGDNFLQRVRSMVFSQERRRSRTSEETSQEAAEQPVDPPPQQPPRPPID 191
            |.......|.||..:   .|.||     |.|.|          |:|..|..::.........|..
Frog     1 MADDEGEEDPGINNM---GNLLQ-----VISSE----------SEEEDEMELEDAKTADSESPNI 47

  Fly   192 IGFDTNLPAEHSYFGNHLSRVPGVDYLEVGSVHHMLIFLH-QHILFPGEVLPF---------MID 246
            |.|||:||..|:|.|..:....|....:..|...:.:..| |.:|.||:.||.         |:.
Frog    48 INFDTSLPTSHAYLGVDMEEFHGRTLHDDDSCQQIPVLPHVQVMLIPGQTLPLHLSRPQEVSMVR 112

  Fly   247 GRMFDED-----MPGLDGLIFGVSFPRLQPPEDNPHKLYGVTCQIY---ERGESGRGLVFYKSRA 303
            | :...|     :...|||            :...|  :|.|.:||   |..|.|...|..|:..
Frog   113 G-LIQRDRTFAVLAYSDGL------------QREAH--FGTTAEIYAYREEHEFGIETVKVKAIG 162

  Fly   304 LQRIVI-----NCDDIKGSPQYIARNPTSKCFSKVKILPEYFLPEPLQTVDMGSMARFRDIPSMR 363
            .||..:     ..|.|:     :||         |:||||..||.|:.::.:.|.:|....|:.:
Frog   163 RQRFQVLETRTQADGIQ-----VAR---------VQILPERVLPCPMTSLQLDSQSRHLLFPTNK 213

  Fly   364 --------------DKYRRFQL---STTTWPSDACQEYSFSSIVERARQRL----ESQKIDTMPK 407
                          .||||.:.   |.|:|||.....|...|::||.:.:|    |:.:.|::|.
Frog   214 PVSGRSPQSKCQWLHKYRRRKFLGASLTSWPSWLYALYDADSLMERVKLQLHEWDENLRDDSLPA 278

  Fly   408 CPIQLSFWLVRNLHLTEKM-MRLTFLTDSVNTRLQLIKSTFKDETLFFCRYC-NSSLALCSDLFA 470
            .||..|:.:...|.:.:.: ::|..:.:::. ||:.........|...|::| ::.:...:::|:
Frog   279 NPIDFSYRVAACLPIDDALRIQLLQIGNAIQ-RLRCELDIMSKCTSLCCKHCPDTEITTKNEIFS 342

  Fly   471 MSKHGVQTQYCNPEGYIHETNTVYRVISHAIGYSGEPSTKFSWFPGYQWHIILCKFCAQHVGWEF 535
            :|..|....|.||.||:|||.|||:..:  :...|.|||:.|||||:.|.|..|:.|..|:||:|
Frog   343 LSLCGPMAAYVNPHGYVHETLTVYKAFN--LSLVGRPSTENSWFPGFAWTIAQCRVCGSHMGWKF 405

  Fly   536 KAVHPNLTPKVFFGLAGSSV--RIGKASE------YSP 565
            .||..:|:|:.|:||..|::  ||.:..|      :||
Frog   406 TAVRKDLSPQKFWGLTRSALQPRIPEPDEGEMGHDHSP 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ohgt	NP_649973.1	PHA02664	<35..109	CDD:177447
ohgt	NP_649973.1	CRBN_C_like	453..555	CDD:276940	41/102 (40%)
crbn	NP_001008192.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		14/63 (22%)
		LON_substr_bdg	82..320	CDD:366967	64/267 (24%)
		CRBN_C_like	324..425	CDD:276940	41/102 (40%)
		Thalidomide binding. /evidence=ECO:0000250\|UniProtKB:Q96SW2	381..389		5/7 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7180
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4291
OMA	1	1.010	-	-		QHG59385
OrthoDB	1	1.010	-	-		D1069900at2759
OrthoFinder	1	1.000	-	-		FOG0004987
OrthoInspector	1	1.000	-	-		oto104197
Panther	1	1.100	-	-	LDO	PTHR14255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3865
SonicParanoid	1	1.000	-	-		X4635
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110