DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ohgt and M18.6

DIOPT Version :9

Sequence 1:	NP_649973.1	Gene:	ohgt / 41230	FlyBaseID:	FBgn0037780	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_502300.2	Gene:	M18.6 / 187461	WormBaseID:	WBGene00010891	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	76/361 - (21%)
Similarity:	127/361 - (35%)	Gaps:	109/361 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 ILFPGEVLP--FMIDGR-----------------MFDEDMPGLDGLIFGVSFPRLQPPEDN--PH 277
            :.|||:.||  |..|.|                 :|..|:|....|.:..:..|:.....|  ..
Worm    72 VCFPGQQLPMKFHDDEREIYERLVSSARANGFVVLFPLDIPECTSLPYIATLSRVVQANSNALSM 136

  Fly   278 KLYGV-TCQIYE----RGESGRGLVFYKSRALQRIVINCDDIKGSPQYIARNPTSKCFSKVKILP 337
            :|.|| .|::.:    |||                                       ::|::||
Worm   137 ELMGVYRCKVLKYNLGRGE---------------------------------------AEVQLLP 162

  Fly   338 EYFLPEPLQTVDMGSMARFRDIPSMRDKY---------RRFQLSTTTWPSDACQEYSFSSIVERA 393
            :..||..|              ||...||         |........:|.:|.::.:.|::.|..
Worm   163 DVELPSLL--------------PSFIPKYAIHLPAHEKRSIATRINGYPFNAIRDVTESAVNECV 213

  Fly   394 RQRLESQKIDTMPKCP----IQLSFWLVRNL---HLTEKMMRLTFLTDSVNTRLQLIKSTFKDET 451
            .........||:.:..    ...|::..:::   .|||..:   ...||.|.|:......||
Worm   214 GLLSGMLGDDTVRQAKDRGLTYFSYFAAKHIFSNRLTEYSL---LKEDSANGRIVAALKYFK--- 272

  Fly   452 LFFCRYCNSSLALCSDLFAMSKHGVQTQYCNPEGYIHETNTVYRVISHAIGY--SGEPSTKFSWF 514
            :|..|.....:.:..:...|........:.|..|::|:..    ::|....|  :..||.:|:||
Worm   273 VFVGRCSRCRIPIFRNEHIMRLPDQTMTHVNAHGFVHKIT----LLSEIRNYDRATPPSYEFTWF 333

  Fly   515 PGYQWHIILCKFCAQHVGWEFKAVHPNLTPKVFFGL 550
            |.|.|.||.|..|.:|:|||:  :.....|:.|||:
Worm   334 PEYAWIIIQCSRCHEHLGWEY--ISMTREPRRFFGI 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ohgt	NP_649973.1	PHA02664	<35..109	CDD:177447
ohgt	NP_649973.1	CRBN_C_like	453..555	CDD:276940	28/100 (28%)
M18.6	NP_502300.2	LON	60..138	CDD:197740	14/65 (22%)
M18.6	NP_502300.2	CRBN_C_like	277..372	CDD:276940	27/97 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1400
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1069900at2759
OrthoFinder	1	1.000	-	-		FOG0004987
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104695
Panther	1	1.100	-	-	LDO	PTHR14255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3865
SonicParanoid	1	1.000	-	-		X4635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.740