DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtTFB2 and tfb2m

DIOPT Version :9

Sequence 1:	NP_649971.1	Gene:	mtTFB2 / 41228	FlyBaseID:	FBgn0037778	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001107089.2	Gene:	tfb2m / 569468	ZFINID:	ZDB-GENE-070521-3	Length:	437	Species:	Danio rerio

Alignment Length:	352	Identity:	96/352 - (27%)
Similarity:	155/352 - (44%)	Gaps:	47/352 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RYS----GDFPEKLLNRKQKVPTHM--YIANSEAAARINQYLEPHFQSSGCDTVMELNSGAGYFT 82
            ||.    ||..|.  .:|..|..::  :|.:...|..:..:|.... ..|...:.|.|.|.|..|
Zfish    87 RYDPLDLGDVDEN--EQKALVCKNLRRFIVDPALATIVTDHLSRDI-DDGKAVIFECNPGPGVLT 148

  Fly    83 RHLLDRESQFRRIILLESMDHFMPKIQELHTLYPERVKVRQGDFVNLWKL---------VYMDKM 138
            |.||:|.:|  |::.|||..:|:|::.||.:....::.|...||..|..:         :|.:|:
Zfish   149 RALLNRGAQ--RVVALESDANFLPELLELESRLEGQLDVVHCDFFKLDPIGNGIMKPPVMYSEKL 211

  Fly   139 DGGSRVADL-LSDVPQKAFTDDINMLVFGAV---GSYPFFKHLINSLIFQTSLFNLGRCEMILAM 199
                 .:|| :|:||   :|.|:.:.:.|..   ........:|.:|..:.|:|..||.|:|:.:
Zfish   212 -----FSDLAISEVP---WTADVPVKIVGLFTQRNERNLMWKMIYNLFERRSIFRYGRVELIMFI 268

  Fly   200 PPPIYIHLTCNNEIGYLIYRSTSVLFQILFEHKFIAKVPREDFLPQQMAYSPTKSSKLGKVQSIN 264
            ....|..|..... .|..|::.|.|.|:.|:.:.:.:.|...||   ...:..:.|..|...| .
Zfish   269 SQKEYTKLVTRPR-DYKNYQAFSALAQMAFDIELLHEEPLSSFL---TTTNNNRKSASGSTLS-Q 328

  Fly   265 PEYLYLVKFTPRRNLHELCQSQDLP----ALWFFIKQNYVSRRNRIIPNLEKWVPGCGPRLIIN- 324
            .|.|.||:.|||   .:|..|...|    .|...:||....|:.::|..:..|.||.|..||.|
Zfish   329 SENLCLVRITPR---EDLFSSHLTPLNGSTLVLMVKQCLAKRKGKLIQQINSWSPGMGSELISNL 390

  Fly   325 PKSSESVT-PIYPDELPKKLPQYSCQS 350
            ....:::| .:||||. |:|.:...||
Zfish   391 GFLDDTLTGDVYPDEY-KRLFELMEQS 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtTFB2	NP_649971.1	AdoMet_MTases	69..309	CDD:302624	69/256 (27%)
tfb2m	NP_001107089.2	P-loop_NTPase	41..>113	CDD:304359	7/27 (26%)
tfb2m	NP_001107089.2	AdoMet_MTases	112..415	CDD:302624	87/322 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11271
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5221
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1169941at2759
OrthoFinder	1	1.000	-	-		FOG0007855
OrthoInspector	1	1.000	-	-		oto39545
orthoMCL	1	0.900	-	-		OOG6_108981
Panther	1	1.100	-	-	LDO	PTHR11727
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6953
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.960