DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and CAF4

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_012962.3	Gene:	CAF4 / 853908	SGDID:	S000001744	Length:	643	Species:	Saccharomyces cerevisiae

Alignment Length:	375	Identity:	88/375 - (23%)
Similarity:	154/375 - (41%)	Gaps:	81/375 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ENAHDS--QLWACTWGRDTAA-------SDPDDAVVEPEENPFDFDKKEARPKDFLVTGGLDD-L 63
            |.:||.  |:.:.|:.|:|.|       .:..:::     ...|||    .|...|.:....| :
Yeast   288 EKSHDKNRQIISETYSRNTTAFRMTIPHGEHGNSI-----TALDFD----TPWGTLCSSSYQDRI 343

  Fly    64 VKVWDLQEDNTLKLRHKLKGHALGVVSVAVSSDG-QTIASSSLDSTMCLWDARSGDKKHLLSFGP 127
            ||||||.....:   .:|.||...|..:.:.... ..:.:.|.|:|:.|||... .::..|...|
Yeast   344 VKVWDLNHGIQV---GELPGHLATVNCMQIDKKNYNMLITGSKDATLKLWDLNL-SREIYLDHSP 404

  Fly   128 VDLWTVQF-SPC-----------------NKYVISGLNDGKISMYSVETGKAEQTLD-------- 166
            :...|.:. :||                 ::.::||..|.||..:.:.|||..|.||
Yeast   405 LKEKTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHWDLTTGKCIQQLDLIFTPTHS 469

  Fly   167 --------AQNGKYTLSI------AYSPDGKYIASGAIDGIITIFDVAAGKVVQTLEGHAMPVRS 217
                    ..||...|..      |.......:|:|..|||:.::|:..||.|:.||||...:.|
Yeast   470 DIKMPARSLNNGACLLGTEAPMIGALQCYNSALATGTKDGIVRLWDLRVGKPVRLLEGHTDGITS 534

  Fly   218 LCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSGHASWVLCVAFSE-DGKHFASSSSDNSVKI- 280
            |.|  :|:.|:|.|.|..::::|:..|.::..:    ::.|.|:..: |||.....:::..|.:
Yeast   535 LKF--DSEKLVTGSMDNSVRIWDLRTSSILDVI----AYDLPVSSLDFDGKLITVGANEGGVNVF 593

  Fly   281 -------WDTSERKCLHTFAEHTDQVWGVRYSPGNDKVASASEDKSLNIY 323
                   |.|.|........|.:.::..|:|..|  .:.:...|..:|::
Yeast   594 NMERDEHWMTPEPPHSLDGDELSRRIAIVKYKDG--FLINGHNDGDINVW 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	76/321 (24%)
		WD40	<54..326	CDD:225201	76/321 (24%)
		WD40 repeat	89..127	CDD:293791	7/38 (18%)
		WD40 repeat	130..166	CDD:293791	12/53 (23%)
		WD40 repeat	174..209	CDD:293791	11/40 (28%)
		WD40 repeat	215..251	CDD:293791	10/35 (29%)
		WD40 repeat	257..293	CDD:293791	9/44 (20%)
		WD40 repeat	299..323	CDD:293791	5/23 (22%)
CAF4	NP_012962.3	Caf4	65..124	CDD:402971
		WD40	318..641	CDD:238121	80/343 (23%)
		WD40 repeat	322..360	CDD:293791	13/49 (27%)
		WD40 repeat	366..422	CDD:293791	11/56 (20%)
		WD40 repeat	427..461	CDD:293791	9/33 (27%)
		WD40 repeat	472..526	CDD:293791	13/53 (25%)
		WD40 repeat	532..563	CDD:293791	10/32 (31%)
		WD40 repeat	571..611	CDD:293791	8/39 (21%)
		WD40 repeat	617..641	CDD:293791	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810