DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and SIF2

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_009661.1	Gene:	SIF2 / 852399	SGDID:	S000000307	Length:	535	Species:	Saccharomyces cerevisiae

Alignment Length:	319	Identity:	72/319 - (22%)
Similarity:	139/319 - (43%)	Gaps:	34/319 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DAVVEPEENPFD-----FDKKEARPKDFLVTGGLDDLVKVWDLQEDNTL--KLRHKLKGHALG-- 87
            |.:|....||.|     :.:|.:..:...:.....:..|.|.|    |:  :|||.....|..
Yeast   158 DNIVSSTWNPLDESILAYGEKNSVARLARIVETDQEGKKYWKL----TIIAELRHPFALSASSGK 218

  Fly    88 ----VVSVAVSSDGQTIASSSLDSTMCLWDARSGDKKHLLSFGPVDLWTVQFSPCNKYVISGLND 148
                |..:|.|.||.:|.:...:..:.||: ::|...::|:|....:.:|:::....::||...:
Yeast   219 TTNQVTCLAWSHDGNSIVTGVENGELRLWN-KTGALLNVLNFHRAPIVSVKWNKDGTHIISMDVE 282

  Fly   149 GKISMYSVETGKAEQ----------TLDAQN----GKYTLSIAYSPDGKYIASGAIDGIITIFDV 199
            ....:::|.:|...|          :::|:|    |...:.:.:..|.|::..|. .|.|.::.:
Yeast   283 NVTILWNVISGTVMQHFELKETGGSSINAENHSGDGSLGVDVEWVDDDKFVIPGP-KGAIFVYQI 346

  Fly   200 AAGKVVQTLEGHAMPVRSLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSGHASWVLCVAFSE 264
            ........|.||..|:..|.|:..::|||:|||||.::::...:.:......||:..::..::..
Yeast   347 TEKTPTGKLIGHHGPISVLEFNDTNKLLLSASDDGTLRIWHGGNGNSQNCFYGHSQSIVSASWVG 411

  Fly   265 DGKHFASSSSDNSVKIWDTSERKCLHTFAEHTDQVWGVRYSPGNDKVASASEDKSLNIY 323
            |.| ..|.|.|.||::|...:...|.........::..|.|....|.|.|..|..:|:|
Yeast   412 DDK-VISCSMDGSVRLWSLKQNTLLALSIVDGVPIFAGRISQDGQKYAVAFMDGQVNVY 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	65/292 (22%)
		WD40	<54..326	CDD:225201	66/292 (23%)
		WD40 repeat	89..127	CDD:293791	10/37 (27%)
		WD40 repeat	130..166	CDD:293791	6/45 (13%)
		WD40 repeat	174..209	CDD:293791	5/34 (15%)
		WD40 repeat	215..251	CDD:293791	10/35 (29%)
		WD40 repeat	257..293	CDD:293791	9/35 (26%)
		WD40 repeat	299..323	CDD:293791	7/23 (30%)
SIF2	NP_009661.1	LisH	7..31	CDD:369916
		WD40	220..516	CDD:421866	58/253 (23%)
		WD40 repeat	224..259	CDD:293791	9/35 (26%)
		WD40 repeat	264..300	CDD:293791	6/35 (17%)
		WD40 repeat	322..356	CDD:293791	5/34 (15%)
		WD40 repeat	362..398	CDD:293791	10/35 (29%)
		WD40 repeat	445..482	CDD:293791	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.970