DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and WDR61

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001290176.1	Gene:	WDR61 / 80349	HGNCID:	30300	Length:	305	Species:	Homo sapiens

Alignment Length:	325	Identity:	170/325 - (52%)
Similarity:	224/325 - (68%)	Gaps:	25/325 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FSVLHKEENAHDSQLWACTWGRDTAASDPDDAVVEPEENPFDFDKKEARPKDFLVTGGLDDLVKV 66
            :.:|.|:|.|||..:|:..||.                     :|||  ..:.:|||.|||||||
Human     5 YGILFKQEQAHDDAIWSVAWGT---------------------NKKE--NSETVVTGSLDDLVKV 46

  Fly    67 WDLQEDNTLKLRHKLKGHALGVVSVAVSSDGQTIASSSLDSTMCLWDARSGDKKHLLSFGPVDLW 131
            |..: |..|.|:..|:||.||||||.:|......||||||:.:.|||..:|.:...:..||||.|
Human    47 WKWR-DERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAW 110

  Fly   132 TVQFSPCNKYVISGLNDGKISMYSVETGKAEQTLDAQNGKYTLSIAYSPDGKYIASGAIDGIITI 196
            |:.|||.::|:.:|.:.||::::.||:||.|.:||.: ||:.|||||||||||:|||||||||.|
Human   111 TLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR-GKFILSIAYSPDGKYLASGAIDGIINI 174

  Fly   197 FDVAAGKVVQTLEGHAMPVRSLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSGHASWVLCVA 261
            ||:|.||::.||||||||:|||.|||:||||:||||||::|:|||.|:::.|||||||||||.||
Human   175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVA 239

  Fly   262 FSEDGKHFASSSSDNSVKIWDTSERKCLHTFAEHTDQVWGVRYSPGNDKVASASEDKSLNIYYCP 326
            |..|..||.|||||.|||:||...|.|:|||.:|.||||||:|:....|:.|..:|:.::||.||
Human   240 FCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304

Fly 327 326
Human 305 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	154/270 (57%)
		WD40	<54..326	CDD:225201	156/271 (58%)
		WD40 repeat	89..127	CDD:293791	14/37 (38%)
		WD40 repeat	130..166	CDD:293791	14/35 (40%)
		WD40 repeat	174..209	CDD:293791	27/34 (79%)
		WD40 repeat	215..251	CDD:293791	23/35 (66%)
		WD40 repeat	257..293	CDD:293791	22/35 (63%)
		WD40 repeat	299..323	CDD:293791	8/23 (35%)
WDR61	NP_001290176.1	WD40	13..302	CDD:238121	164/313 (52%)
		WD 1	14..57		22/66 (33%)
		WD40 repeat	19..62	CDD:293791	21/66 (32%)
		WD 2	62..101		19/38 (50%)
		WD40 repeat	68..105	CDD:293791	14/36 (39%)
		WD 3	104..143		18/38 (47%)
		WD40 repeat	110..146	CDD:293791	15/35 (43%)
		WD 4	146..187		29/41 (71%)
		WD40 repeat	152..188	CDD:293791	28/35 (80%)
		WD 5	188..227		26/38 (68%)
		WD40 repeat	193..229	CDD:293791	23/35 (66%)
		WD 6	230..269		25/38 (66%)
		WD40 repeat	236..271	CDD:293791	21/34 (62%)
		WD 7	272..305		15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157347
Domainoid	1	1.000	51	1.000	Domainoid score	I11638
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5884
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2367
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1052423at2759
OrthoFinder	1	1.000	-	-		FOG0006473
OrthoInspector	1	1.000	-	-		oto90427
orthoMCL	1	0.900	-	-		OOG6_103719
Panther	1	1.100	-	-	LDO	PTHR44090
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1078
SonicParanoid	1	1.000	-	-		X4723
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800