DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and Wdr72

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001028672.2	Gene:	Wdr72 / 546144	MGIID:	3583957	Length:	1114	Species:	Mus musculus

Alignment Length:	280	Identity:	64/280 - (22%)
Similarity:	111/280 - (39%)	Gaps:	69/280 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 LRHKLKGHAL--------GVVSVAVSSDGQTIASSSLDSTMCLWDARSGDK---KHLLSFGPVDL 130
            :|..|:..||        .:.::.::.|.|||.:.|.:..:|||......|   |.|| ||....
Mouse     1 MRGALQAVALWGRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELKISAKELL-FGHSAS 64

  Fly   131 WTV-----QFSPCNKYVISGLNDGKISMYSVETGK-AEQT-LDAQNGK---YTLSIAYSPDGKYI 185
            .|.     .||. ..||:|...:|::.|::|.:|: .|:| |..::..   |..|...:.:|..:
Mouse    65 VTCLARARDFSK-QPYVVSAAENGEMCMWNVSSGQCVEKTSLPYRHTAICYYHCSFRMTGEGWLL 128

  Fly   186 ASGAIDGIITIFDVAAGKVVQTLEGHAMP--VRSLCFSPNSQL----LLTASDDGHMKLYDVTHS 244
            ..|....:: :.|.....|:.|......|  ::.:|...:.::    ||..|..|.:|::|:
Mouse   129 CCGEYQDVL-VLDAGTLAVLHTFTSLQSPDWMKCMCIVHSVRIQEDSLLVVSITGELKVWDL--- 189

  Fly   245 DVVGTLSGHASWVLCVAFSEDGKHFASSSSDNSV-KIWDTSER--KCLHTFAEHTDQVWGVRYSP 306
                                       |||.||: :..|..|:  |.|.:|...|     :|:.|
Mouse   190 ---------------------------SSSINSIQEKQDVHEKESKFLDSFNCQT-----IRFCP 222

  Fly   307 GNDKVASASEDKSLNIY-YC 325
            ..:::......|...|| ||
Mouse   223 YTERLLLVVFSKCWKIYDYC 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	60/275 (22%)
		WD40	<54..326	CDD:225201	64/280 (23%)
		WD40 repeat	89..127	CDD:293791	13/40 (33%)
		WD40 repeat	130..166	CDD:293791	12/42 (29%)
		WD40 repeat	174..209	CDD:293791	6/34 (18%)
		WD40 repeat	215..251	CDD:293791	7/39 (18%)
		WD40 repeat	257..293	CDD:293791	9/38 (24%)
		WD40 repeat	299..323	CDD:293791	3/23 (13%)
Wdr72	NP_001028672.2	WD40	14..>191	CDD:392136	42/209 (20%)
		WD 1. /evidence=ECO:0000255	15..54		9/38 (24%)
		WD40 repeat	20..60	CDD:293791	12/40 (30%)
		WD 2. /evidence=ECO:0000255	60..102		11/42 (26%)
		WD40 repeat	66..107	CDD:293791	13/41 (32%)
		WD40 repeat	112..151	CDD:293791	7/39 (18%)
		WD40 repeat	160..206	CDD:293791	14/75 (19%)
		WD 3. /evidence=ECO:0000255	160..197		12/66 (18%)
		WD 4. /evidence=ECO:0000255	327..373
		WD 5. /evidence=ECO:0000255	413..452
		WD40	418..>606	CDD:392136
		WD40 repeat	419..470	CDD:293791
		WD 6. /evidence=ECO:0000255	470..515
		WD40 repeat	475..516	CDD:293791
		WD 7. /evidence=ECO:0000255	566..605
		WD40 repeat	571..597	CDD:293791
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..658
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900