DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and wdr61

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_988871.1	Gene:	wdr61 / 394466	XenbaseID:	XB-GENE-5751496	Length:	305	Species:	Xenopus tropicalis

Alignment Length:	325	Identity:	167/325 - (51%)
Similarity:	229/325 - (70%)	Gaps:	25/325 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FSVLHKEENAHDSQLWACTWGRDTAASDPDDAVVEPEENPFDFDKKEARPKDFLVTGGLDDLVKV 66
            :|:|.|:|:||:..:|:..||:::     :|.                  .:.:::|.|||||||
Frog     5 YSILFKQEHAHEDAIWSVGWGKNS-----NDG------------------SELVISGSLDDLVKV 46

  Fly    67 WDLQEDNTLKLRHKLKGHALGVVSVAVSSDGQTIASSSLDSTMCLWDARSGDKKHLLSFGPVDLW 131
            |. ..|..|:|:..|:||.||||||.||..|..:||||||:.:.|||..||.:...:..||||.|
Frog    47 WK-WSDERLELQSTLEGHQLGVVSVDVSPSGNIMASSSLDAHIRLWDLESGKQIRAIDAGPVDAW 110

  Fly   132 TVQFSPCNKYVISGLNDGKISMYSVETGKAEQTLDAQNGKYTLSIAYSPDGKYIASGAIDGIITI 196
            :|.|||.::::.:|.:.||::::.|||||.|.:||.: ||:.|||||||||||:|||||||||.|
Frog   111 SVAFSPDSQHLATGSHVGKVNIFGVETGKKEYSLDTR-GKFILSIAYSPDGKYLASGAIDGIINI 174

  Fly   197 FDVAAGKVVQTLEGHAMPVRSLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSGHASWVLCVA 261
            ||:|.||::.||||||||:|||.|||:||||:||||||::|:|:|.|:.:..|||||.||||.||
Frog   175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYEVQHASLAATLSGHGSWVLNVA 239

  Fly   262 FSEDGKHFASSSSDNSVKIWDTSERKCLHTFAEHTDQVWGVRYSPGNDKVASASEDKSLNIYYCP 326
            ||.|..||.|||||.|||:||.|.|.|:|||.:|.||||||:|:....|:.|.::|:.:::|.||
Frog   240 FSPDDTHFVSSSSDKSVKVWDVSARTCVHTFLDHQDQVWGVKYNKNGSKIVSVADDQEIHVYDCP 304

Fly 327 326
Frog 305 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	154/270 (57%)
		WD40	<54..326	CDD:225201	155/271 (57%)
		WD40 repeat	89..127	CDD:293791	17/37 (46%)
		WD40 repeat	130..166	CDD:293791	14/35 (40%)
		WD40 repeat	174..209	CDD:293791	27/34 (79%)
		WD40 repeat	215..251	CDD:293791	21/35 (60%)
		WD40 repeat	257..293	CDD:293791	24/35 (69%)
		WD40 repeat	299..323	CDD:293791	8/23 (35%)
wdr61	NP_988871.1	WD 1	14..57		17/66 (26%)
		WD40	15..302	CDD:238121	159/311 (51%)
		WD40 repeat	19..62	CDD:293791	17/66 (26%)
		WD 2	62..101		22/38 (58%)
		WD40 repeat	68..105	CDD:293791	17/36 (47%)
		WD 3	104..143		18/38 (47%)
		WD40 repeat	110..145	CDD:293791	14/34 (41%)
		WD 4	146..187		29/41 (71%)
		WD40 repeat	152..187	CDD:293791	27/34 (79%)
		WD 5	188..227		25/38 (66%)
		WD40 repeat	193..229	CDD:293791	21/35 (60%)
		WD 6	230..269		26/38 (68%)
		WD40 repeat	235..272	CDD:293791	25/36 (69%)
		WD 7	272..305		14/33 (42%)
		WD40 repeat	277..301	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11303
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5884
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2274
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1052423at2759
OrthoFinder	1	1.000	-	-		FOG0006473
OrthoInspector	1	1.000	-	-		oto104232
Panther	1	1.100	-	-	LDO	PTHR44090
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1078
SonicParanoid	1	1.000	-	-		X4723
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110