DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and caf4

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001342939.1	Gene:	caf4 / 3361526	PomBaseID:	SPAC664.15	Length:	651	Species:	Schizosaccharomyces pombe

Alignment Length:	331	Identity:	78/331 - (23%)
Similarity:	137/331 - (41%)	Gaps:	70/331 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DFDKKEARPKDFLVTGGLDDLVKVWDLQEDNTLKLRHKLKGHALGVVSVAVSSDGQTIASSSLDS 107
            ||    :.|...|.|...|..|||||:.   .:.....||||:..|..:|:..  ..||:.|:|:
pombe   339 DF----SHPFGTLATASTDKTVKVWDMA---GVVYLGSLKGHSDYVSCLAIQD--SFIATGSMDT 394

  Fly   108 TMCLWDARSGDKKHLLSFGPVD----------------LWTVQFSP-------CNKYVISGLNDG 149
            |:.||:.   |...|....||:                :.|...:|       .:..:|:|.:|.
pombe   395 TVRLWNL---DNDVLHKDNPVEESLNSPPDQPVDNATNVLTSHTAPVTALALSSDDVLITGADDK 456

  Fly   150 KISMYSVETGKAEQTL--------DAQNGKYTLSIAYSPD---------GKYIASGAIDGIITIF 197
            .:..:.:.||:..|||        |....:..:|..|..:         ...:|||.:||:|.|:
pombe   457 TVRQWDIVTGRCIQTLDFVWAETHDTSTSQILVSDTYKQEPFIRALDCLDAAVASGTVDGLIRIW 521

  Fly   198 DVAAGKVVQTLEGHAMPVRSLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSGHASWVLCVAF 262
            |:..|..|::..||..|:.||.|..|.  |.:.|.|..::::|:.....:..:..... |..:..
pombe   522 DLRIGLPVRSFIGHTAPISSLQFDSNH--LYSGSYDNSVRIWDLRSGSPINIIPMEKK-VNSLRL 583

  Fly   263 SEDGKHFASSSSDNSVKIWDT-SERKCLHTFAEHTDQV--------WGVRYSPGNDK-VASASED 317
            .:.  ..|.:|.:.:|:|:|| |.|..:.:...|:|.:        ..|:|   .|: :.....|
pombe   584 YQG--RLAVASDEPNVRIFDTVSNRNWICSIPSHSDSIAAEPNSVPTSVQY---KDRFLVDGKSD 643

  Fly   318 KSLNIY 323
            .|::::
pombe   644 GSVSVF 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	75/320 (23%)
		WD40	<54..326	CDD:225201	75/320 (23%)
		WD40 repeat	89..127	CDD:293791	10/37 (27%)
		WD40 repeat	130..166	CDD:293791	10/50 (20%)
		WD40 repeat	174..209	CDD:293791	12/43 (28%)
		WD40 repeat	215..251	CDD:293791	8/35 (23%)
		WD40 repeat	257..293	CDD:293791	9/36 (25%)
		WD40 repeat	299..323	CDD:293791	5/32 (16%)
caf4	NP_001342939.1	WD40	324..650	CDD:238121	78/331 (24%)
		WD40 repeat	336..372	CDD:293791	12/39 (31%)
		WD40 repeat	377..431	CDD:293791	13/58 (22%)
		WD40 repeat	439..473	CDD:293791	7/33 (21%)
		WD40 repeat	484..533	CDD:293791	12/48 (25%)
		WD40 repeat	539..573	CDD:293791	8/35 (23%)
		WD40 repeat	578..600	CDD:293791	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860