DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3909 and cdt2

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_593588.1	Gene:	cdt2 / 2542374	PomBaseID:	SPAC17H9.19c	Length:	490	Species:	Schizosaccharomyces pombe

Alignment Length:	380	Identity:	81/380 - (21%)
Similarity:	133/380 - (35%)	Gaps:	143/380 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EEN-----------AHDSQLWACTWGRD-----TAASDPDDAVVEPEENPFDFDKKE-------- 48
            |||           ||::.:::..:.:|     |::.|....|       ||...::
pombe   164 EENQPSARRIHGWLAHNNAIFSVNFSKDDSLLATSSGDQTSKV-------FDLSTQQCITRLGRR 221

  Fly    49 ---------ARPKDF-------LVTGGLDDLVKVWDLQ-----------EDNTLKLR--HKLKGH 84
                     .:..:|       ||:...|..:..||::           :...|::|  |:..|.
pombe   222 GVDGYHSHSVKQVNFCNDSPYNLVSCSRDGSIIFWDMRTHGITIDGEHFQKPVLRIRKAHENSGR 286

  Fly    85 ALGVVSVA--VSSDGQTIASSSLDSTMCLWDARSGDKKHLL-------------SFGPVDLWTVQ 134
            ...:.|..  ..|..|.|:|.|.:|.:.|||.|:......|             .||..::.|
pombe   287 DCSITSATWLPQSTSQVISSCSANSALKLWDLRTVHTVRPLPAATTPELTTSKRDFGVTNVCT-- 349

  Fly   135 FSPCNKYVISGLNDGKISMYS---VETGKAEQTLD--AQNGKYTLSIAYSPDGKYIASGAIDGI- 193
             ||..:.:.:...|..|..||   :.:|..:...|  .:...:.:.:|.||||..:|.|.  |:
pombe   350 -SPDGERIYAASRDSIIYEYSSRHLNSGFCKTYKDPRLRISSFYVKLACSPDGATLACGG--GVQ 411

  Fly   194 -----ITIFDVAAGKVVQTLEGHAMPVRSLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSGH 253
                 :.:||....                |   :|..:||.   ||.|  |||..|
pombe   412 DKTSGVVVFDTTRN----------------C---SSSAMLTG---GHTK--DVTAVD-------- 444

  Fly   254 ASWVLCVAFSEDGKHFASSSSDNSVKIWDTSERKCLHTFAEHTDQ-------VWG 301
              |      |.:|: .||.|.|.||::|::|    ||..|.:..:       .||
pombe   445 --W------SSEGQ-LASISDDGSVRVWNSS----LHGSAANLREKNFSEIFYWG 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	70/303 (23%)
		WD40	<54..326	CDD:225201	70/301 (23%)
		WD40 repeat	89..127	CDD:293791	13/52 (25%)
		WD40 repeat	130..166	CDD:293791	8/38 (21%)
		WD40 repeat	174..209	CDD:293791	10/40 (25%)
		WD40 repeat	215..251	CDD:293791	11/35 (31%)
		WD40 repeat	257..293	CDD:293791	12/35 (34%)
		WD40 repeat	299..323	CDD:293791	2/3 (67%)
cdt2	NP_593588.1	WD40 repeat	131..178	CDD:293791	3/13 (23%)
		WD40	<132..208	CDD:295369	9/50 (18%)
		WD40	<171..490	CDD:225201	78/373 (21%)
		WD40	173..464	CDD:295369	71/343 (21%)
		WD40 repeat	184..222	CDD:293791	6/44 (14%)
		WD40 repeat	231..279	CDD:293791	7/47 (15%)
		WD40 repeat	291..337	CDD:293791	12/45 (27%)
		WD40 repeat	344..382	CDD:293791	8/40 (20%)
		WD40 repeat	392..433	CDD:293791	12/61 (20%)
		WD40 repeat	440..463	CDD:293791	12/39 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960