DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3909 and rec14

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_596145.1	Gene:	rec14 / 2540221	PomBaseID:	SPBC32F12.02	Length:	302	Species:	Schizosaccharomyces pombe

Alignment Length:	334	Identity:	94/334 - (28%)
Similarity:	145/334 - (43%)	Gaps:	54/334 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FSVLHKEENAHDSQLWACTWGRDTAASDPDDAVVEPEENPFDFDKKEARPKDFLVTGGL-----D 61
            :.|.|.|||||.:.:::..                                  :|.|.|     |
pombe     5 YLVSHIEENAHQADIYSLN----------------------------------VVAGNLWSASGD 35

  Fly    62 DLVKVWDLQEDNTLKLRHKL-----KGHALGVVSVAVSSDGQTIASSSLDSTMCLWDARSGDKKH 121
            ..:|.|.:.:     ..|.|     ..|.|||..:|.|.|...:.|......:.:|:..:.:.:.
pombe    36 SKIKKWSIGD-----AEHSLVEEIDTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNEFRD 95

  Fly   122 LLSFG--PVDLWTVQFSPCNKYVISGLNDGKISMYSVETGKAEQTLDAQNGKYTLSIAYSPDGKY 184
            |.:..  |.:.|:...||..:.:.....||:|:::...:......||.: ||:.|.|.|||:|::
pombe    96 LGNNAQHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTK-GKFGLCIDYSPNGRF 159

  Fly   185 IASGAIDGIITIFDVAAGKVVQTLEGHAMPVRSLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGT 249
            |.||...|.:.:.....|::...|.||..||||:.|||.|.||..|.|...:.:|||...|.||.
pombe   160 IVSGHQTGQLFLISTETGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQ 224

  Fly   250 LSGHASWVLCVAFSEDGKHFASSSSDNSVKIWDTSERKCLHTFAEHTDQVWGVRYSPGNDKVASA 314
            |.|||:|:..|||:..|....|:..:..:||||....:|:.|.:|....:|.|.:......||.|
pombe   225 LRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDIDTMECISTQSETDGAIWAVAWYKNGFIVAGA 289

  Fly   315 SEDKSLNIY 323
              |||:..|
pombe   290 --DKSIRWY 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	86/282 (30%)
		WD40	<54..326	CDD:225201	87/282 (31%)
		WD40 repeat	89..127	CDD:293791	6/39 (15%)
		WD40 repeat	130..166	CDD:293791	6/35 (17%)
		WD40 repeat	174..209	CDD:293791	11/34 (32%)
		WD40 repeat	215..251	CDD:293791	17/35 (49%)
		WD40 repeat	257..293	CDD:293791	11/35 (31%)
		WD40 repeat	299..323	CDD:293791	8/23 (35%)
rec14	NP_596145.1	WD40	5..>296	CDD:225201	93/332 (28%)
		WD40	15..297	CDD:238121	88/324 (27%)
		WD40 repeat	63..98	CDD:293791	6/34 (18%)
		WD40 repeat	103..142	CDD:293791	7/38 (18%)
		WD40 repeat	149..184	CDD:293791	11/34 (32%)
		WD40 repeat	190..226	CDD:293791	17/35 (49%)
		WD40 repeat	232..267	CDD:293791	10/34 (29%)
		WD40 repeat	274..296	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5884
Inparanoid	1	1.050	139	1.000	Inparanoid score	I1377
OMA	1	1.010	-	-		QHG53955
OrthoFinder	1	1.000	-	-		FOG0006473
OrthoInspector	1	1.000	-	-		oto101491
orthoMCL	1	0.900	-	-		OOG6_103719
Panther	1	1.100	-	-	LDO	PTHR44090
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1078
SonicParanoid	1	1.000	-	-		X4723
TreeFam	1	0.960	-	-
	12	11.860