DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and hif2

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_587735.1	Gene:	hif2 / 2538701	PomBaseID:	SPCC1235.09	Length:	564	Species:	Schizosaccharomyces pombe

Alignment Length:	374	Identity:	86/374 - (22%)
Similarity:	143/374 - (38%)	Gaps:	78/374 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KEENAHDSQLWACTWGRDTAASDPDDAVV----EPEENPFDF--------DKKEARP-------- 51
            :..|::|.||...   :|..:..|...|:    :.|:...|.        :|..|||
pombe   118 EHNNSNDHQLKIL---QDKGSGSPSSPVMPFKDKIEKRDIDITMADESNVEKDPARPIAVYNSSP 179

  Fly    52 -------KDFLVTGGLD---DLVKVWDLQEDNTLKLRHKLKGHALGVVSVAVSSDGQTIASSSL- 105
                   |....|||.|   |..||...:...|......|......|...::.....|:||.|:
pombe   180 VTEITEIKQVTFTGGEDIKSDFFKVIPTKHPVTCADWRPLLQENYHVYEFSIGMTNATLASVSIC 244

  Fly   106 --------DSTMCLWDARSGDKKHLLSFGPVDLWTVQFSPCNKYVISGLNDGKISMYSVETGKAE 162
                    .:..||..          ||...|:..|.::....::......|.|.:|.   ....
pombe   245 EEQNDFKAKTDYCLQS----------SFDNQDITGVAWNNSGSFLAYAFFSGVIEIYD---SHGS 296

  Fly   163 QTLDAQNGK-YTLSIAYSPDGKYIASGAIDGIITIFD--VAAGKVVQTLEGHAMPVRSLCFSPNS 224
            |.|...|.| ..||:.:|....|:|:|:.||.||:||  ......:.||....:.:..:.|..
pombe   297 QILSFHNNKGPVLSLKWSGTDTYLAAGSADGTITLFDQLKQTQYSIDTLASSVLDIEWISFDE-- 359

  Fly   225 QLLLTASDDGHMKLYDVTHSDVVGTLS-GHASWVLCVAFSEDGKHFASSSSDNSVKIW---DTSE 285
              .:|:..:|.:::|.|.....|.|:| .|.:.::.:.::.......::|||.:||:|   |...
pombe   360 --FVTSDVEGSLRVYKVDGKAPVSTVSHAHDNSIVALRYNLRISLLLTASSDTTVKLWSRGDAGA 422

  Fly   286 RKCLHTFAEHTDQV----WGVRYSPGNDKVASASEDKSLNIYYCPPNAI 330
            .:|||.|: .:..|    |.:|  .|...:|.|| :..:::|    |||
pombe   423 FECLHVFS-FSSPVNCIDWNLR--EGTPILAVAS-NSIVSMY----NAI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	69/293 (24%)
		WD40	<54..326	CDD:225201	69/294 (23%)
		WD40 repeat	89..127	CDD:293791	8/46 (17%)
		WD40 repeat	130..166	CDD:293791	5/35 (14%)
		WD40 repeat	174..209	CDD:293791	13/36 (36%)
		WD40 repeat	215..251	CDD:293791	7/35 (20%)
		WD40 repeat	257..293	CDD:293791	10/38 (26%)
		WD40 repeat	299..323	CDD:293791	7/27 (26%)
hif2	NP_587735.1	LisH	4..30	CDD:285685
		WD40	<263..524	CDD:225201	54/216 (25%)
		WD40	267..523	CDD:295369	53/212 (25%)
		WD40 repeat	267..301	CDD:293791	6/36 (17%)
		WD40 repeat	309..347	CDD:293791	14/37 (38%)
		WD40 repeat	349..384	CDD:293791	7/38 (18%)
		WD40 repeat	392..430	CDD:293791	10/37 (27%)
		WD40 repeat	435..472	CDD:293791	11/36 (31%)
		WD40 repeat	478..515	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.970