DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and rbc-2

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001368042.1	Gene:	rbc-2 / 190267	WormBaseID:	WBGene00004314	Length:	1373	Species:	Caenorhabditis elegans

Alignment Length:	234	Identity:	52/234 - (22%)
Similarity:	92/234 - (39%)	Gaps:	50/234 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DAVVEPEENPFDFDKKEARPKDFLVTGGLDDLVKVWDLQEDNTLKLRHKLKGHALGVVSVAVSSD 96
            ||.|.....||:.|.:  ....:.|:|..|..|.||::.....:   |:...|...|.|..:...
Worm   485 DAAVRSMFYPFEHDTR--YDPQYFVSGSDDFSVIVWNINSGTRI---HRFTVHGGPVKSFMLPPS 544

  Fly    97 G------QTIASSSLDSTMCLWDARSGDKKHLLSFGPVDLWTVQFSPCNKYVISGLNDGKISMYS 155
            .      :.|||.:.|:|:.|.:.|......|.|..|..:..|::.|.:.:::..|.||.:.::.
Worm   545 NCSKQVTKCIASLAADNTIALLNIRDSKCMLLASRHPFPIIQVKWRPLDDFMLVKLADGSVYVWQ 609

  Fly   156 VETGKAEQTLDAQNGKYTLSIAYSPDGKYIASGAI-DGIITIFDVAAG---KVVQTLEGHAMPVR 216
            :||...::                     ||:|.: :.|:|..|...|   ...:|...||:.
Worm   610 METANLDR---------------------IATGLLAEDIMTACDEQIGVEEGTDETSAHHAVQ-- 651

  Fly   217 SLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSGHAS 255
                      |:.|..:.:|:.  |....|.|::||.|:
Worm   652 ----------LIRALKNKNMEA--VKQKVVGGSVSGAAT 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	46/214 (21%)
		WD40	<54..326	CDD:225201	46/212 (22%)
		WD40 repeat	89..127	CDD:293791	10/43 (23%)
		WD40 repeat	130..166	CDD:293791	7/35 (20%)
		WD40 repeat	174..209	CDD:293791	8/38 (21%)
		WD40 repeat	215..251	CDD:293791	6/35 (17%)
		WD40 repeat	257..293	CDD:293791
		WD40 repeat	299..323	CDD:293791
rbc-2	NP_001368042.1	WD40	27..>118	CDD:421866
		WD40 repeat	33..68	CDD:293791
		WD40 repeat	73..108	CDD:293791
		WD40 repeat	112..160	CDD:293791
		WD40 repeat	168..211	CDD:293791
		WD40 repeat	264..291	CDD:293791
		WD40	373..621	CDD:421866	35/161 (22%)
		WD40 repeat	488..530	CDD:293791	11/46 (24%)
		WD40 repeat	584..610	CDD:293791	5/25 (20%)
		WD40	<1246..1313	CDD:421866
		WD40 repeat	1286..1337	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900