Protein Alignment CG3909 and Apaf1

DIOPT Version :10

• Sequence 1: NP_649969.1
• Gene: CG3909 / 41226
• FlyBaseID: FBgn0027524
• Length: 331
• Species: Drosophila melanogaster
• Sequence 2: NP_033814.2
• Gene: Apaf1 / 11783
• MGIID: 1306796
• Length: 1249
• Species: Mus musculus
• Alignment Length: 376
• Identity: 82/376 - (21%)
• Similarity: 148/376 - (39%)
• Gaps: 91/376 - (24%)

  Fly    11 AHDSQLWACTWGRD-----TAASDPD----DAVVEPEENPFDFDKKEARPKDF--------LVTG 58
            ||:.::..|.:..|     |.::|..    |:......:.:|...::.....|        |.||
Mouse   655 AHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQVNCCHFTNKSNHLLLATG 719

  Fly    59 GLDDLVKVWDLQEDNTLKLRHKLKGHALGVVSVAVSSDGQTIASSSLDSTMCLWDARSGDKKHLL 123
            ..|..:|:|||   |..:.|:.:.||...|.....|.|.:.:||.|.|.|:.|||.||.:::
Mouse   720 SNDFFLKLWDL---NQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANER--- 778

  Fly   124 SFGPVDLWTVQFSPCNKYVISGLNDGKISMYSVETGKAEQTLDAQNGKYTLSIAYSPDGKYIASG 188
                                ..:|..:..:.|.:..:..:.:       ....::|.||..|...
Mouse   779 --------------------KSINVKRFFLSSEDPPEDVEVI-------VKCCSWSADGDKIIVA 816

  Fly   189 AIDGIITIFDV-AAGKVVQTLEGHAMPVRSLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSG 252
            |.:.:: :||: .:|.:.:...||...::...|||...|.:.|.....::|:::.....|....|
Mouse   817 AKNKVL-LFDIHTSGLLAEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRG 880

  Fly   253 HASWVLCVAFSEDGKHFASSSSDNSVKIWDTSERKCLHT-----------FAEH------TDQVW 300
            |.|||..|.||.||..|.::|.|.::::|:| ::.|.::           |.|:      .|.:.
Mouse   881 HLSWVHGVMFSPDGSSFLTASDDQTIRVWET-KKVCKNSAIVLKQEIDVVFQENETMVLAVDNIR 944

  Fly   301 GVR---------------------YSPGNDKVASASEDKSLNIYYCPPNAI 330
            |::                     .||..:.||...||.::.|...|.|.:
Mouse   945 GLQLIAGKTGQIDYLPEAQVSCCCLSPHLEYVAFGDEDGAIKIIELPNNRV 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	<54..323	CDD:441893	71/315 (23%)
		WD40 repeat	89..127	CDD:293791	12/37 (32%)
		WD40 repeat	130..166	CDD:293791	2/35 (6%)
		WD40 repeat	174..209	CDD:293791	8/35 (23%)
		WD40 repeat	215..251	CDD:293791	7/35 (20%)
		WD40 repeat	257..293	CDD:293791	12/46 (26%)
		WD40 repeat	299..323	CDD:293791	7/44 (16%)
Apaf1	NP_033814.2	CARD_APAF1	7..92	CDD:260034
		NB-ARC	129..374	CDD:395745
		APAF1_C	453..587	CDD:465560
		WD 1-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	613..652
		WD40	623..1207	CDD:441893	82/376 (22%)
		WD40 repeat	623..655	CDD:293791	82/376 (22%)
		WD 1-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	655..694		7/38 (18%)
		WD40 repeat	661..697	CDD:293791	5/35 (14%)
		WD 1-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	697..738		11/43 (26%)
		WD40 repeat	702..740	CDD:293791	11/40 (28%)
		WD 1-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	741..780		15/61 (25%)
		WD40 repeat	747..789	CDD:293791	13/64 (20%)
		eIF2A	<796..931	CDD:462552	33/143 (23%)
		WD 1-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	796..837		8/48 (17%)
		WD40 repeat	801..837	CDD:293791	8/36 (22%)
		WD 1-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	838..877		9/38 (24%)
		WD40 repeat	843..882	CDD:293791	8/38 (21%)
		WD 1-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	880..910		13/29 (45%)
		WD40 repeat	885..909	CDD:293791	9/23 (39%)
		Interpropeller linker	910..921		2/11 (18%)
		WD 2-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	922..958		4/35 (11%)
		WD 2-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	959..998		9/37 (24%)
		WD40 repeat	964..999	CDD:293791	9/32 (28%)
		WD 2-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	1001..1040
		WD40 repeat	1006..1030	CDD:293791
		WD 2-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	1042..1080
		WD40 repeat	1048..1082	CDD:293791
		WD 2-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	1083..1122
		WD40 repeat	1089..1124	CDD:293791
		WD 2-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	1125..1164
		WD40 repeat	1130..1174	CDD:293791
		WD 2-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	1176..1213
		WD40 repeat	1181..1203	CDD:293791
		WD 2-8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944	1214..1249