DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3909 and Apaf1

DIOPT Version :9

Sequence 1:	NP_649969.1	Gene:	CG3909 / 41226	FlyBaseID:	FBgn0027524	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001036023.1	Gene:	Apaf1 / 11783	MGIID:	1306796	Length:	1249	Species:	Mus musculus

Alignment Length:	376	Identity:	82/376 - (21%)
Similarity:	148/376 - (39%)	Gaps:	91/376 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AHDSQLWACTWGRD-----TAASDPD----DAVVEPEENPFDFDKKEARPKDF--------LVTG 58
            ||:.::..|.:..|     |.::|..    |:......:.:|...::.....|        |.||
Mouse   655 AHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQVNCCHFTNKSNHLLLATG 719

  Fly    59 GLDDLVKVWDLQEDNTLKLRHKLKGHALGVVSVAVSSDGQTIASSSLDSTMCLWDARSGDKKHLL 123
            ..|..:|:|||   |..:.|:.:.||...|.....|.|.:.:||.|.|.|:.|||.||.:::
Mouse   720 SNDFFLKLWDL---NQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANER--- 778

  Fly   124 SFGPVDLWTVQFSPCNKYVISGLNDGKISMYSVETGKAEQTLDAQNGKYTLSIAYSPDGKYIASG 188
                                ..:|..:..:.|.:..:..:.:       ....::|.||..|...
Mouse   779 --------------------KSINVKRFFLSSEDPPEDVEVI-------VKCCSWSADGDKIIVA 816

  Fly   189 AIDGIITIFDV-AAGKVVQTLEGHAMPVRSLCFSPNSQLLLTASDDGHMKLYDVTHSDVVGTLSG 252
            |.:.:: :||: .:|.:.:...||...::...|||...|.:.|.....::|:::.....|....|
Mouse   817 AKNKVL-LFDIHTSGLLAEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRG 880

  Fly   253 HASWVLCVAFSEDGKHFASSSSDNSVKIWDTSERKCLHT-----------FAEH------TDQVW 300
            |.|||..|.||.||..|.::|.|.::::|:| ::.|.::           |.|:      .|.:.
Mouse   881 HLSWVHGVMFSPDGSSFLTASDDQTIRVWET-KKVCKNSAIVLKQEIDVVFQENETMVLAVDNIR 944

  Fly   301 GVR---------------------YSPGNDKVASASEDKSLNIYYCPPNAI 330
            |::                     .||..:.||...||.::.|...|.|.:
Mouse   945 GLQLIAGKTGQIDYLPEAQVSCCCLSPHLEYVAFGDEDGAIKIIELPNNRV 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3909	NP_649969.1	WD40	52..323	CDD:238121	71/317 (22%)
		WD40	<54..326	CDD:225201	72/318 (23%)
		WD40 repeat	89..127	CDD:293791	12/37 (32%)
		WD40 repeat	130..166	CDD:293791	2/35 (6%)
		WD40 repeat	174..209	CDD:293791	8/35 (23%)
		WD40 repeat	215..251	CDD:293791	7/35 (20%)
		WD40 repeat	257..293	CDD:293791	12/46 (26%)
		WD40 repeat	299..323	CDD:293791	7/44 (16%)
Apaf1	NP_001036023.1	CARD_APAF1	7..92	CDD:260034
		NB-ARC	129..374	CDD:395745
		APAF1_C	453..587	CDD:407760
		WD40	607..910	CDD:238121	66/288 (23%)
		WD 1-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	613..652
		WD40 repeat	623..655	CDD:293791	82/376 (22%)
		WD 1-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	655..694		7/38 (18%)
		WD40 repeat	661..697	CDD:293791	5/35 (14%)
		WD 1-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	697..738		11/43 (26%)
		WD40 repeat	702..740	CDD:293791	11/40 (28%)
		WD 1-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	741..780		15/61 (25%)
		WD40 repeat	747..789	CDD:293791	13/64 (20%)
		WD 1-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	796..837		8/48 (17%)
		WD40 repeat	801..837	CDD:293791	8/36 (22%)
		WD 1-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	838..877		9/38 (24%)
		WD40 repeat	843..882	CDD:293791	8/38 (21%)
		WD 1-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	880..910		13/29 (45%)
		WD40 repeat	885..909	CDD:293791	9/23 (39%)
		Interpropeller linker	910..921		2/11 (18%)
		WD 2-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	922..958		4/35 (11%)
		WD 2-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	959..998		9/37 (24%)
		WD40	961..1235	CDD:238121	9/35 (26%)
		WD40 repeat	964..999	CDD:293791	9/32 (28%)
		WD 2-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1001..1040
		WD40 repeat	1006..1030	CDD:293791
		WD 2-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1042..1080
		WD40 repeat	1048..1082	CDD:293791
		WD 2-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1083..1122
		WD40 repeat	1089..1124	CDD:293791
		WD 2-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1125..1164
		WD40 repeat	1130..1174	CDD:293791
		WD 2-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1176..1213
		WD40 repeat	1181..1203	CDD:293791
		WD 2-8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1214..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810