|
Fly 46 EHAAAAEAAELFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKF 110
|....|:|.::|:....|:|.:..|.....:...:.|.|....:||.:||:||.:|||:|||.|.
Human 5 EDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKL 69
Fly 111 DARAAHRVYGKGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVI 175
|.|.:|:.|.:|.:||.|:.|::|.||||||||||...|||||||:||||..:||||||||||.|
Human 70 DKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTI 134
Fly 176 TDLRNLGAKKFYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGG----G 236
.|||.||||||||||||||||||||||||.:|.||||:||||||..|.|...:||..|.. |
Human 135 HDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIG 199
Fly 237 WRAAVTPADHPVSHYEFDVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAKVEEIS 300
|||...|.||.:|.:||||:|||||:||.|: ||||||||||||||||||||:.:.|||||||||
Human 200 WRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEIS 264
Fly 301 GVAFIFNQAFFKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPAN 365
||||||||.||::|..:|||||||||||||.||||||||||.||:||||||.|..|...||...|
Human 265 GVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAEN 329
Fly 366 VDTQKLHDYAREAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQC 430
|:...|..||||||:|:|.||:|:|:||:||||:|||||||||.|:|:|.:..|..|:..:|:..
Human 330 VNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVA 394
Fly 431 LVGDSLLEPFWPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQR 495
||||||||||||.|:|||||||::.|.|:.:|.| |.....|.:||:|||:||||.||||:.:.:
Human 395 LVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSW-NQGTPPLELLAERESLYRLLPQTTPENINK 458
Fly 496 DISAYTVDPATRYPNLNRESVNSWQVKHLVDTDDPSILEQTFMDTHALQTPHLDTPG--RR---- 554
:...||:||.|||||||...|...|||||..|.: |:...|:..| ||
Human 459 NFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKE-------------LEHYPLERLGSVRRSVNL 510
Fly 555 KRRSGDLLPQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMS 619
.|:..|:.| :.||.|...|...||.: .:.:.:..:|:|..|||:|:|:||:||::.:..:..
Human 511 SRKESDIRP--SKLLTWCQQQTEGYQHV-NVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDD 572
Fly 620 PVECNELSFAVLERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSD 684
.||.|:|:|.|.|||..|..|.:.|:.....|.:....:.||.:..:||||. |......
Human 573 AVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGT------PLRPVDS 631
Fly 685 LRQKYRINH--THAQPDFSK--LLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLL 745
.|:.|..|. :.|:...|. |..|.|:.::|..|. ...|.:..||:|:....|
Human 632 WRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDG----------QTGENDMNKRRRKGFTNL 686
Fly 746 NIGGGAAGAAAGVAGSGTGTTTQGQNDTPRRSKKRRQVDKTANILLLRTALCHEISNAISAFETI 810
:.....:..:.| :....|::.:|.| :.:|...||.||.: ||
Human 687 DEPSNFSSRSLG-SNQECGSSKEGGN--------QNKVKSMANQLLAK-------------FE-- 727
Fly 811 NEEERQQRLQEIEENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDY 875
|..|...|. :||| :.....|.:....:|..:... ....|:.||....
Human 728 -ESTRNPSLM-----KQER----------RVSGIGKPVLCSSSGPPVHSC--CPKPEEATPSPSP 774
Fly 876 SIFLYRQQAP---VFNDRVKDLERK------LLFPDRER-------------GDIPSALPRTADE 918
.: ::|.| |....:::|::. |..|.|.| ..:||..||. :
Human 775 PL---KRQFPSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRA--Q 834
Fly 919 QFSD---RIKNMEQRMTGRGGLGGDKKPKDLMRAIGKIDSNDWNVREIEKKIE------------ 968
..|. |::.:|::: |.:....:.:.:::.:.|::|..
Human 835 ALSGVLWRLQQVEEKI--------------LQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFP 885
Fly 969 ----LSK-KTEIHGPKGREKVPKWSKEQFQARQHK---MSKPQRQDSREAEKFKDIDQTIRNLDK 1025
||| .:..|.|....::| |.:...:.... .:.|.|::.:....|......:|.:..
Human 886 QNKLLSKGLSHTHPPSPPSRLP--SPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHP 948
Fly 1026 QLKEGH-NLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTNNTVIPKSSSKVALAFK 1089
||..|. :..:|......|.........|.:|.|.:..:...:...|.
Human 949 QLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNL----------------- 996
Fly 1090 KQAASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFR 1154
..|:.|.|||:.||:||:.:.||...||.|.:|..|.|.|||..|.||.| :|:|||..||
Human 997 --GGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCD--EGKFYCKPHF- 1056
Fly 1155 LPPKPLPQRTN-KARKSAA-------------AQPASPAVPPTAGSVPTAA-ATSEHM---DTTP 1201
:..:|| |.||..| .|.|.....||..|...|| .|.|.. :.|.
Human 1057 -----IHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPDEPTS 1116
Fly 1202 PRDQVDLLETSRANASADAMSDDEANVIDEHEWSGRNFLPESNNDSQSEL-------SSSDESDT 1259
|:....:.|...::|..||.|...: ||:.....|......|..| |....|||
Human 1117 PKRPKSISEPQHSDAEGDAASPLPS------EWTSVRISPGEEAAGQDVLAVRVLVTSEDSSSDT 1175
Fly 1260 ESD-----SEMFEEADDSPFGAQTLQLASDWIGK-------QYCEDS--------DDSDDFYDSS 1304
||| ....|..::.|:...:..|....:|: ..|.:. ..::.| .|
Human 1176 ESDYGGSEGSHTEPCEEKPWRPGSPHLPHTSLGEALSRAVSPQCPEEPRAVHAALQRANSF--QS 1238
Fly 1305 EDDGKDDTEGEEF--------KKARELRRQEVRLQPLPANL------PTDTETEKLKLNVDNKEN 1355
....|......|| |:.....:......|||::. |:.:.|.. ..|
Human 1239 PTPSKYQNWRREFWWSLTPVNKRTMSPPKDPSPSLPLPSSSSHSSSPPSSSSTSV-------SGN 1296
Fly 1356 MADRSSLKSGNSFES----ARSQPSTPLSTPTRVEMEQLERNAPRK------------------- 1397
..|.||.....:.|. :|..||.| || ......:.:.|||:
Human 1297 APDGSSPPQMTASEPLSQVSRGHPSPP--TP-NFRRRAVAQGAPREIPLYLPHHPKPEWAEYCLV 1358
Fly 1398 ------FSSEIEAISEKLY------------HMNNMVKMNKD-------LEVLAKEN-------- 1429
.|...|..|::.. |.:......|| |..||.|:
Human 1359 SPGEDGLSDPAEMTSDECQPAEAPLGDIGSNHRDPHPIWGKDRSWTGQELSPLAGEDREKGSTGA 1423
Fly 1430 ---------LVKSDI-LRKLTLKEK-------W---LAENAAIAAGQKVTPTPSATAPGLQPKSK 1474
|||..: |:||.|.:: | :.|:..:.||:::: .||.
Human 1424 RKEEEGGPVLVKEKLGLKKLVLTQEQKTMLLDWNDSIPESVHLKAGERIS-----------QKSA 1477
Fly 1475 FDEKFEKVVSPPQPVVEPKPKPVIDFNLDELKPRKPNFEER---PKEQLPRPESLKKPPQQKPKG 1536
.:.:..:|:.|.:|::.|:. ..|..|.:...:|: |.||.....:: ||.:.|..
Human 1478 ENGRGGRVLKPVRPLLLPRA-------AGEPLPTQRGAQEKMGTPAEQAQGERNV--PPPKSPLR 1533
Fly 1537 SSTNVSRSN--SLKSNASNGSPKVKKAPISNNSK---MQIEGILGTLRKIQSQNSSDQDEDMDVD 1596
...|..|.: .|.||:..| |||.....|| .|......:|||..|....||
Human 1534 LIANAIRRSLEPLLSNSEGG----KKAWAKQESKTLPAQACTRSFSLRKTNSNKDGDQ------- 1587
Fly 1597 EDVERKPNKELNSKLKEIQASSFAGTMDHIKSQLTMPTVSAQAPPSMDLSKYFPNQKQEKSSTSS 1661
..|.:. |:|:|:. ..|.:...:.|:.. ||.||..: ....|.
Human 1588 ----HSPGRN--------QSSAFSP---------PDPALRTHSLPNRP-SKVFPALR--SPPCSK 1628
Fly 1662 TNKNQVTLKDVNLAKYFPSSPAPQRRTVETVAD-RLKKSQTEAALAKTKLLEDQANNQAEKTKKE 1725
.......|:.|:|.:.||.:..|.::.:...:. |||....|:.|.:::..:| ..:.....|::
Human 1629 IEDVPTLLEKVSLQENFPDASKPPKKRISLFSSLRLKDKSFESFLQESRQRKD-IRDLFGSPKRK 1692
Fly 1726 VEKEGESKKITKKVADSKAV-----------------PPKRQASLDT--FSLREHQMDGALDLTK 1771
|..|..::.:.|.:...|:. ||......|: |.||
Human 1693 VLPEDSAQALEKLLQPFKSTSLRQAAPPPPPPPPPPPPPPTAGGADSKNFPLR------------ 1745
Fly 1772 KKGPTKASAGVKKPAKSGSTTSVTKATATSKGK-TIKIVKKIVPKGTKAKKAAEAAQESAVVEAP 1835
|.|.:.:.|.|:||.:.|......: ::::.:| |..:.:|..|.|.:..|.:..
Human 1746 --------AQVTEASSSASSTSSSSADEEFDPQLSLQLKEK---KTLRRRKKLEKAMKQLVKQEE 1799
Fly 1836 PEKKPPKDEAERILDEILGDGEYRSPSSEYQRLFQDEKSPSDLSDNIDRILEESGLDVELGLPKR 1900
.::.......:|.|:|: |.|..:||.| |:.:|..|
Human 1800 LKRLYKAQAIQRQLEEV----EERQRASEIQ-----------------------GVRLEKAL--- 1834
Fly 1901 SSKKLVKTKSLGEGDFDMKPSKE------RLTGVQNILKRFESMSSVTSQNSDEQAAFKLRRMES 1959
.||.|...:...: :|...:|.|.|:||...:.:|..: :|.
Human 1835 ----------RGEADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELE---------LED 1880
Fly 1960 TTSNLSSLTRSRESLVSVSDSMSDLEKTMDYLRNEWRNEATNFLQ--KKRDKFYAKKEEQEKESK 2022
..|.|.. :.||.::. .:|..| ||.: ||.:...|..:| ::|||.....|||....|
Human 1881 HQSRLEQ--KLREKMLK-EESQKD-EKDL----NEEQEVFTELMQVIEQRDKLVDSLEEQRIREK 1937
Fly 2023 2022
Human 1938 1937
| 
