DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mical and MICAL2

DIOPT Version :9

Sequence 1:NP_001247015.1 Gene:Mical / 41225 FlyBaseID:FBgn0053208 Length:4743 Species:Drosophila melanogaster
Sequence 2:NP_001380866.1 Gene:MICAL2 / 9645 HGNCID:24693 Length:1957 Species:Homo sapiens


Alignment Length:2210 Identity:651/2210 - (29%)
Similarity:948/2210 - (42%) Gaps:510/2210 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 EHAAAAEAAELFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKF 110
            |....|:|.::|:....|:|.:..|.....:...:.|.|....:||.:||:||.:|||:|||.|.
Human     5 EDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKL 69

  Fly   111 DARAAHRVYGKGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVI 175
            |.|.:|:.|.:|.:||.|:.|::|.||||||||||...|||||||:||||..:||||||||||.|
Human    70 DKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTI 134

  Fly   176 TDLRNLGAKKFYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGG----G 236
            .|||.||||||||||||||||||||||||.:|.||||:||||||..|.|...:||..|..    |
Human   135 HDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIG 199

  Fly   237 WRAAVTPADHPVSHYEFDVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAKVEEIS 300
            |||...|.||.:|.:||||:|||||:||.|: ||||||||||||||||||||:.:.|||||||||
Human   200 WRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEIS 264

  Fly   301 GVAFIFNQAFFKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPAN 365
            ||||||||.||::|..:|||||||||||||.||||||||||.||:||||||.|..|...||...|
Human   265 GVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAEN 329

  Fly   366 VDTQKLHDYAREAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQC 430
            |:...|..||||||:|:|.||:|:|:||:||||:|||||||||.|:|:|.:..|..|:..:|:..
Human   330 VNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVA 394

  Fly   431 LVGDSLLEPFWPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQR 495
            ||||||||||||.|:|||||||::.|.|:.:|.| |.....|.:||:|||:||||.||||:.:.:
Human   395 LVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSW-NQGTPPLELLAERESLYRLLPQTTPENINK 458

  Fly   496 DISAYTVDPATRYPNLNRESVNSWQVKHLVDTDDPSILEQTFMDTHALQTPHLDTPG--RR---- 554
            :...||:||.|||||||...|...|||||..|.:             |:...|:..|  ||    
Human   459 NFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKE-------------LEHYPLERLGSVRRSVNL 510

  Fly   555 KRRSGDLLPQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMS 619
            .|:..|:.|  :.||.|...|...||.: .:.:.:..:|:|..|||:|:|:||:||::.:..:..
Human   511 SRKESDIRP--SKLLTWCQQQTEGYQHV-NVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDD 572

  Fly   620 PVECNELSFAVLERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSD 684
            .||.|:|:|.|.|||..|..|.:.|:.....|.:....:.||.:..:||||.      |......
Human   573 AVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGT------PLRPVDS 631

  Fly   685 LRQKYRINH--THAQPDFSK--LLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLL 745
            .|:.|..|.  :.|:...|.  |..|.|:.::|..|.          ...|.:..||:|:....|
Human   632 WRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDG----------QTGENDMNKRRRKGFTNL 686

  Fly   746 NIGGGAAGAAAGVAGSGTGTTTQGQNDTPRRSKKRRQVDKTANILLLRTALCHEISNAISAFETI 810
            :.....:..:.| :....|::.:|.|        :.:|...||.||.:             ||  
Human   687 DEPSNFSSRSLG-SNQECGSSKEGGN--------QNKVKSMANQLLAK-------------FE-- 727

  Fly   811 NEEERQQRLQEIEENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDY 875
             |..|...|.     :|||          :.....|.:....:|..:...  ....|:.||....
Human   728 -ESTRNPSLM-----KQER----------RVSGIGKPVLCSSSGPPVHSC--CPKPEEATPSPSP 774

  Fly   876 SIFLYRQQAP---VFNDRVKDLERK------LLFPDRER-------------GDIPSALPRTADE 918
            .:   ::|.|   |....:::|::.      |..|.|.|             ..:||..||.  :
Human   775 PL---KRQFPSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRA--Q 834

  Fly   919 QFSD---RIKNMEQRMTGRGGLGGDKKPKDLMRAIGKIDSNDWNVREIEKKIE------------ 968
            ..|.   |::.:|:::              |.:....:.:.:::.:.|::|..            
Human   835 ALSGVLWRLQQVEEKI--------------LQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFP 885

  Fly   969 ----LSK-KTEIHGPKGREKVPKWSKEQFQARQHK---MSKPQRQDSREAEKFKDIDQTIRNLDK 1025
                ||| .:..|.|....::|  |.:...:....   .:.|.|::.:....|......:|.:..
Human   886 QNKLLSKGLSHTHPPSPPSRLP--SPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHP 948

  Fly  1026 QLKEGH-NLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTNNTVIPKSSSKVALAFK 1089
            ||..|. :..:|......|.........|.:|.|.:..:...:...|.                 
Human   949 QLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNL----------------- 996

  Fly  1090 KQAASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFR 1154
              ..|:.|.|||:.||:||:.:.||...||.|.:|..|.|.|||..|.||.|  :|:|||..|| 
Human   997 --GGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCD--EGKFYCKPHF- 1056

  Fly  1155 LPPKPLPQRTN-KARKSAA-------------AQPASPAVPPTAGSVPTAA-ATSEHM---DTTP 1201
                 :..:|| |.||..|             .|.|.....||..|...|| .|.|..   :.|.
Human  1057 -----IHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPDEPTS 1116

  Fly  1202 PRDQVDLLETSRANASADAMSDDEANVIDEHEWSGRNFLPESNNDSQSEL-------SSSDESDT 1259
            |:....:.|...::|..||.|...:      ||:.....|......|..|       |....|||
Human  1117 PKRPKSISEPQHSDAEGDAASPLPS------EWTSVRISPGEEAAGQDVLAVRVLVTSEDSSSDT 1175

  Fly  1260 ESD-----SEMFEEADDSPFGAQTLQLASDWIGK-------QYCEDS--------DDSDDFYDSS 1304
            |||     ....|..::.|:...:..|....:|:       ..|.:.        ..::.|  .|
Human  1176 ESDYGGSEGSHTEPCEEKPWRPGSPHLPHTSLGEALSRAVSPQCPEEPRAVHAALQRANSF--QS 1238

  Fly  1305 EDDGKDDTEGEEF--------KKARELRRQEVRLQPLPANL------PTDTETEKLKLNVDNKEN 1355
            ....|......||        |:.....:......|||::.      |:.:.|..       ..|
Human  1239 PTPSKYQNWRREFWWSLTPVNKRTMSPPKDPSPSLPLPSSSSHSSSPPSSSSTSV-------SGN 1296

  Fly  1356 MADRSSLKSGNSFES----ARSQPSTPLSTPTRVEMEQLERNAPRK------------------- 1397
            ..|.||.....:.|.    :|..||.|  || ......:.:.|||:                   
Human  1297 APDGSSPPQMTASEPLSQVSRGHPSPP--TP-NFRRRAVAQGAPREIPLYLPHHPKPEWAEYCLV 1358

  Fly  1398 ------FSSEIEAISEKLY------------HMNNMVKMNKD-------LEVLAKEN-------- 1429
                  .|...|..|::..            |.:......||       |..||.|:        
Human  1359 SPGEDGLSDPAEMTSDECQPAEAPLGDIGSNHRDPHPIWGKDRSWTGQELSPLAGEDREKGSTGA 1423

  Fly  1430 ---------LVKSDI-LRKLTLKEK-------W---LAENAAIAAGQKVTPTPSATAPGLQPKSK 1474
                     |||..: |:||.|.::       |   :.|:..:.||::::           .||.
Human  1424 RKEEEGGPVLVKEKLGLKKLVLTQEQKTMLLDWNDSIPESVHLKAGERIS-----------QKSA 1477

  Fly  1475 FDEKFEKVVSPPQPVVEPKPKPVIDFNLDELKPRKPNFEER---PKEQLPRPESLKKPPQQKPKG 1536
            .:.:..:|:.|.:|::.|:.       ..|..|.:...:|:   |.||.....::  ||.:.|..
Human  1478 ENGRGGRVLKPVRPLLLPRA-------AGEPLPTQRGAQEKMGTPAEQAQGERNV--PPPKSPLR 1533

  Fly  1537 SSTNVSRSN--SLKSNASNGSPKVKKAPISNNSK---MQIEGILGTLRKIQSQNSSDQDEDMDVD 1596
            ...|..|.:  .|.||:..|    |||.....||   .|......:|||..|....||       
Human  1534 LIANAIRRSLEPLLSNSEGG----KKAWAKQESKTLPAQACTRSFSLRKTNSNKDGDQ------- 1587

  Fly  1597 EDVERKPNKELNSKLKEIQASSFAGTMDHIKSQLTMPTVSAQAPPSMDLSKYFPNQKQEKSSTSS 1661
                ..|.:.        |:|:|:.         ..|.:...:.|:.. ||.||..:  ....|.
Human  1588 ----HSPGRN--------QSSAFSP---------PDPALRTHSLPNRP-SKVFPALR--SPPCSK 1628

  Fly  1662 TNKNQVTLKDVNLAKYFPSSPAPQRRTVETVAD-RLKKSQTEAALAKTKLLEDQANNQAEKTKKE 1725
            .......|:.|:|.:.||.:..|.::.:...:. |||....|:.|.:::..:| ..:.....|::
Human  1629 IEDVPTLLEKVSLQENFPDASKPPKKRISLFSSLRLKDKSFESFLQESRQRKD-IRDLFGSPKRK 1692

  Fly  1726 VEKEGESKKITKKVADSKAV-----------------PPKRQASLDT--FSLREHQMDGALDLTK 1771
            |..|..::.:.|.:...|:.                 ||......|:  |.||            
Human  1693 VLPEDSAQALEKLLQPFKSTSLRQAAPPPPPPPPPPPPPPTAGGADSKNFPLR------------ 1745

  Fly  1772 KKGPTKASAGVKKPAKSGSTTSVTKATATSKGK-TIKIVKKIVPKGTKAKKAAEAAQESAVVEAP 1835
                    |.|.:.:.|.|:||.:.|......: ::::.:|   |..:.:|..|.|.:..|.:..
Human  1746 --------AQVTEASSSASSTSSSSADEEFDPQLSLQLKEK---KTLRRRKKLEKAMKQLVKQEE 1799

  Fly  1836 PEKKPPKDEAERILDEILGDGEYRSPSSEYQRLFQDEKSPSDLSDNIDRILEESGLDVELGLPKR 1900
            .::.......:|.|:|:    |.|..:||.|                       |:.:|..|   
Human  1800 LKRLYKAQAIQRQLEEV----EERQRASEIQ-----------------------GVRLEKAL--- 1834

  Fly  1901 SSKKLVKTKSLGEGDFDMKPSKE------RLTGVQNILKRFESMSSVTSQNSDEQAAFKLRRMES 1959
                      .||.|...:...:      :|...:|.|.|:||...:.:|..:         :|.
Human  1835 ----------RGEADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELE---------LED 1880

  Fly  1960 TTSNLSSLTRSRESLVSVSDSMSDLEKTMDYLRNEWRNEATNFLQ--KKRDKFYAKKEEQEKESK 2022
            ..|.|..  :.||.::. .:|..| ||.:    ||.:...|..:|  ::|||.....|||....|
Human  1881 HQSRLEQ--KLREKMLK-EESQKD-EKDL----NEEQEVFTELMQVIEQRDKLVDSLEEQRIREK 1937

  Fly  2023  2022
            Human  1938  1937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MicalNP_001247015.1 MDR <114..>160 CDD:302572 27/45 (60%)
CH 563..>629 CDD:294029 22/65 (34%)
LIM_Mical 1097..1153 CDD:188823 27/55 (49%)
Ehrlichia_rpt <2081..2479 CDD:118064
DUF3585 4592..4705 CDD:288945
MICAL2NP_001380866.1 Monooxygenase domain. /evidence=ECO:0000250|UniProtKB:Q8VDP3 2..494 295/502 (59%)
UbiH 87..>226 CDD:357568 95/138 (69%)
CH 522..617 CDD:214479 32/95 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..714 11/72 (15%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:24440334 660..681 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..942 10/57 (18%)
LIM_Mical 1002..1056 CDD:188823 27/55 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1072..1094 2/21 (10%)
PHA03247 <1087..1624 CDD:223021 121/609 (20%)
ProQ 1628..1718 CDD:198013 17/90 (19%)
DUF5401 <1773..>1944 CDD:375164 47/225 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 480 1.000 Domainoid score I415
eggNOG 1 0.900 - - E2759_KOG1700
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001313
OrthoInspector 1 1.000 - - otm41401
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4660
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.800

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