DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mical and MICAL1

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	NP_001273542.1	Gene:	MICAL1 / 64780	HGNCID:	20619	Length:	1086	Species:	Homo sapiens

Alignment Length:	1463	Identity:	416/1463 - (28%)
Similarity:	592/1463 - (40%)	Gaps:	485/1463 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QQLLMAEHAAAAEAAELFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQ 104
            |:..||...:...|...|:....|...:.:|:..:.:|.|:||.|......|.::|.::..|.|:
Human    16 QEASMASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEPGGGLPQYHKIKDQLNYWSAK 80

  Fly   105 ALWKKFDARAAHRVYGKGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLH 169
            :||.|.|.||...||.:|.|||.|:.||:||||||||.|:|..||||:||::|||.:.:|:||||
Human    81 SLWTKLDKRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVELALLGARVVLVEKRTKFSRHNVLH 145

  Fly   170 LWPFVITDLRNLGAKKFYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDG 234
            ||||.|.|||.||||||||:||.|::|||||||||.:|||||||||||||.||:|.....|...|
Human   146 LWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVTFTGLQPPPRKG 210

  Fly   235 GGWRAAVTPADHP---VSHYEFDVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAK 295
            .||||.:.|  :|   :::|||||||.|.|.:.:.: |:.:|.||||||.|||||:|.:|..|.:
Human   211 SGWRAQLQP--NPPAQLANYEFDVLISAAGGKFVPEGFKVREMRGKLAIGITANFVNGRTVEETQ 273

  Fly   296 VEEISGVAFIFNQAFFKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGEL 360
            |.||||||.|:||:||:.|...|||||||||||||:||||||||||..|:..||:.:|..|...|
Human   274 VPEISGVARIYNQSFFQSLLKATGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDWPDTNRL 338

  Fly   361 LAPANVDTQKLHDYAREAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGA 425
            |..|||..:.|..:.|.||:|:|..::..||||.:.:|:|||:.||||||..||.|.||..:.||
Human   339 LGSANVVPEALQRFTRAAADFATHGKLGKLEFAQDAHGQPDVSAFDFTSMMRAESSARVQEKHGA 403

  Fly   426 RLMQCLVGDSLLEPFWPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTP 490
            ||:..||||.|:|||||.|:|.|||||::.|||:.:|.|:....| |.|||:|||:|:||:||:|
Human   404 RLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAES-LEVLAERESLYQLLSQTSP 467

  Fly   491 DTLQRDISAYTVDPATRYPNLNRESVNSWQVKHLVD--TDDPSILEQTFMDTHALQTPHLDTPGR 553
            :.:.|:::.|.:||||||||||..:|...||:.|.|  ..:|........||   ..|...:.|.
Human   468 ENMHRNVAQYGLDPATRYPNLNLRAVTPNQVRDLYDVLAKEPVQRNNDKTDT---GMPATGSAGT 529

  Fly   554 RKRRSGDLLPQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDM 618
            ::.           ||||...|...|..: .:.:.|..:.:|..||||:.|.:|.|::.:..:.:
Human   530 QEE-----------LLRWCQEQTAGYPGV-HVSDLSSSWADGLALCALVYRLQPGLLEPSELQGL 582

  Fly   619 SPVECNELSFAVLERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFS 683
            ..:|....:..|.|.||.|..|:||:.                     :..|..|
Human   583 GALEATAWALKVAENELGITPVVSAQA---------------------VVAGSDP---------- 616

  Fly   684 DLRQKYRINHTHAQPDFSKLLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLLNIG 748
             |.....::|.|:        |.|..|.||
Human   617 -LGLIAYLSHFHS--------AFKSMAHSP----------------------------------- 637

  Fly   749 GGAAGAAAGVAGSGTGTTTQGQNDTPRRSKKRRQVDKTANILLLRTALCHEISNAISAFETINEE 813
            |..:.|:.|.:                                             ||...:::.
Human   638 GPVSQASPGTS---------------------------------------------SAVLFLSKL 657

  Fly   814 ERQQRLQEIEENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDYSIF 878
            :|..:....:||.::                       ..||.||...||.......|
Human   658 QRTLQRSRAKENAED-----------------------AGGKKLRLEMEAETPSTEVP------- 692

  Fly   879 LYRQQAPVFNDRVKDLERKLLFPDRERGDIPSALPRTADEQFSDRIKNMEQRMTGRGGLGGDKKP 943
                                  ||.|.| :|...|
Human   693 ----------------------PDPEPG-VPLTPP------------------------------ 704

  Fly   944 KDLMRAIGKIDSNDWNVREIEKKIELSKKTEIHGPKGREKVPKWSKEQFQARQHKMSKPQRQDSR 1008

Human   705 ----------------------------------------------------------------- 704

  Fly  1009 EAEKFKDIDQTIRNLDKQLKEGHNLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTN 1073
                                                             |..:.||
Human   705 -------------------------------------------------SQHQEAG--------- 711

  Fly  1074 NTVIPKSSSKVALAFKKQAASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAF 1138
                               |.:.|..|.:.:|::|:..|.|...||:|.:||.|...|..|||
Human   712 -------------------AGDLCALCGEHLYVLERLCVNGHFFHRSCFRCHTCEATLWPGGY-- 755

  Fly  1139 DRDDPQGRFYCTQHFRLPPKPLPQRTNKARKSAAAQPASPAVP-PTAGSVP----TAAATSEHM- 1197
            ::....|.|||.||       |||..:||..|... |.||.:| |:..|:|    |..|:.|..
Human   756 EQHPGDGHFYCLQH-------LPQTDHKAEGSDRG-PESPELPTPSENSMPPGLSTPTASQEGAG 812

  Fly  1198 ----DTTPPRDQVDLLETSRANASADAMSDD-----------EANVIDEHE-------WSGRNFL 1240
                .:.|.|.|:.|....|...|:..::.|           ..:.:..|.       |.    |
Human   813 PVPDPSQPTRRQIRLSSPERQRLSSLNLTPDPEMEPPPKPPRSCSALARHALESSFVGWG----L 873

  Fly  1241 PESNNDSQSELSSSDESDTESDSEMFEEADDSPFGAQTLQLASDWIGKQYCEDSDDSDDFYDSSE 1305
            |.   .|...|.:.::.:.||.....||.:|.|.                  |||........::
Human   874 PV---QSPQALVAMEKEEKESPFSSEEEEEDVPL------------------DSDVEQALQTFAK 917

  Fly  1306 DDG---------------KDDTEGEEFKKARELRRQEVRLQPLPANLPTDTETEKLKLNVDNKEN 1355
            ..|               ..:.|.:.|.||:.::|   ||..:.|.| .:.|.|.:||.:
Human   918 TSGTMNNYPTWRRTLLRRAKEEEMKRFCKAQTIQR---RLNEIEAAL-RELEAEGVKLEL----- 973

  Fly  1356 MADRSSLKSGNSFESARSQPSTPLSTPTRVEMEQLERNAPRKFSSEIEA-----------ISEKL 1409
                          :.|.|.|:| ....::.:.||.:...:|.|...|.           :.||.
Human   974 --------------ALRRQSSSP-EQQKKLWVGQLLQLVDKKNSLVAEEAELMITVQELNLEEKQ 1023

  Fly  1410 YHMNNMVK--MNKDLEV-LAKENLVKSDILRKL 1439
            :.::..::  ||::..: .|.:...:..:||||
Human  1024 WQLDQELRGYMNREENLKTAADRQAEDQVLRKL 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572	28/45 (62%)
		CH	563..>629	CDD:294029	16/65 (25%)
		LIM_Mical	1097..1153	CDD:188823	21/55 (38%)
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945
MICAL1	NP_001273542.1	NAD_binding_8	108..>135	CDD:290186	18/26 (69%)
		CH	530..626	CDD:278723	27/139 (19%)
		USP19_linker	632..712	CDD:293210	27/384 (7%)
		LIM_Mical_like	716..769	CDD:188744	20/54 (37%)
		DUF3585	946..1079	CDD:288945	29/135 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8510
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001313
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103078
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.670