Protein Alignment Mical and lima1a

DIOPT Version :10

• Sequence 1: NP_001247015.1
• Gene: Mical / 41225
• FlyBaseID: FBgn0053208
• Length: 4743
• Species: Drosophila melanogaster
• Sequence 2: NP_571739.1
• Gene: lima1a / 64000
• ZFINID: ZDB-GENE-001120-1
• Length: 629
• Species: Danio rerio
• Alignment Length: 602
• Identity: 128/602 - (21%)
• Similarity: 195/602 - (32%)
• Gaps: 202/602 - (33%)

  Fly   910 SALPRTADEQFSDRIKNMEQRMTG--RGGLGGDK-------------KPK-----DLMRAIGKI- 953
            |...:.|:|...|:.|:.|:...|  .|.|...|             :||     .|.::..||
Zfish    40 SKYQKAAEETSLDKKKSPEKSTPGLRNGNLSVLKQLWEHPAETPTSPEPKAHLQNHLQQSAVKIP 104

  Fly   954 -DSNDWNVRE-------------IEKKIELSKKTEIHGPKGREKVPKWS-KEQFQARQHKMSKPQ 1003
             :|.|..:.|             :||:.:...:|.|..|    .||..| |..|:..:...|...
Zfish   105 LESTDVQLIEGTDQQCLSDSDQPMEKRTQRDVETLIEKP----TVPLNSLKMMFEKGETLHSNVS 165

  Fly  1004 RQDSREAEKFKDIDQTIRNLDKQLKEGHNLDVGERG------RNKVASIAGQFGKKDEANSDEKN 1062
            |:.....:...|      |::...||  :|:.|.:.      |:::|.......|.|..:|....
Zfish   166 REPGTTGDSGSD------NMEPGTKE--SLECGVKMLDSTPLRDRMAMYQAAVTKLDFPSSPNSE 222

  Fly  1063 AGSSNA--------------------TTNTNNTVIPKSSSKVALAFKKQ---------AASEKCR 1098
            |..|.|                    .:||..:..|..:..|....:.|         ...|.|.
Zfish   223 AADSEARAHSGKQKENVPPVSADVCPESNTIKSPAPDRNGSVLSPEQNQPKLVKMFPLPVRETCV 287

  Fly  1099 FCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHF---------- 1153
            .|.:|||.:||......:.|..|.:|.:|:|.|.|..||    ......||..|:
Zfish   288 TCLKTVYPLEKLVANQQIYHNTCFRCAYCNTKLSLVNYA----SLHNNVYCKPHYCQLFKAKGNY 348

  Fly  1154 -----RLPPKPL---------------PQRTNKARKSAAAQPASPAVPPT--AGSVPT-AAATSE 1195
                 ..|.|.|               ||.|:...:.      ||.|...  |.::.| ..||||
Zfish   349 DEGFGHRPHKELWEGRPEGVDDQVKLSPQETSLTVEE------SPLVKVNVLAATLETRTQATSE 407

  Fly  1196 HMDTTPPRDQVDLLETSRANASADAMSD-DEA---NVID-------EHEWSGRNFLPESNNDSQS 1249
            .::..        |||.|...|....|: ||:   .|.|       ..:|........||.|.:|
Zfish   408 RVEKP--------LETGRLKISWPPQSEGDESATHTVTDGSGIKPIRPKWPPEGDTVSSNVDLES 464

  Fly  1250 EL--------------------------------SSSDESDTESDSEMFEEADDSPFGAQTLQLA 1282
            :|                                |.|:|. .:|:.||      ||..:.|....
Zfish   465 DLPKLRRSVSLKERSKPFCIFDSAPVAQPKRCQRSPSNEK-PDSEEEM------SPVSSTTDTTI 522

  Fly  1283 SDWIGKQYCEDSDDSDDFYDSSEDDGKDDTEGEEFKKARELRRQEVRLQPLPANLPTDT-----E 1342
            |          |:|..:...|.|:|.....|.|:.:...::..||..|..|..:.|.::     |
Zfish   523 S----------SEDMTEHNQSEEEDQDKTKEDEQMEHEEKVDVQEEELSSLKCSTPDNSPPLSPE 577

  Fly  1343 TEKLKLNVDNKENMADR 1359
            :|.   .:|.:||.|.:
Zfish   578 SES---GLDPEENQASQ 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	UbiH	128..>263	CDD:440419
		CH_SF	567..669	CDD:469584
		LIM_Mical	1097..1153	CDD:188823	18/55 (33%)
		PRK10819	<1450..>1557	CDD:236768
		bMERB_dom	4592..4705	CDD:463467
lima1a	NP_571739.1	LIM_Eplin_alpha_beta	286..338	CDD:188869	18/55 (33%)