DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mical and mical2a

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	XP_021333692.1	Gene:	mical2a / 569607	ZFINID:	ZDB-GENE-110110-2	Length:	1292	Species:	Danio rerio

Alignment Length:	1311	Identity:	445/1311 - (33%)
Similarity:	614/1311 - (46%)	Gaps:	284/1311 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKFDARAAHRVYG 120
            ||:....||..:..|.....:|.::.|.|...:.||..||:.:..|||:|||.|.|.||:|:.|.
Zfish    15 LFENFVQATDCKSTLQAFNILCGSLELDPLEHSSFYGSLKSSLTCWKAKALWSKLDKRASHKEYK 79

  Fly   121 KGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVITDLRNLGAKK 185
            ||.||.|.:.|:||.||||||||||...|||||||:||||..:|||||||||:.|.|||.|||||
Zfish    80 KGRACEGIKCLIIGGGPCGLRTAIELAFLGAKVVVIEKRDTFSRNNVLHLWPYTIHDLRALGAKK 144

  Fly   186 FYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGD----GGGWRAAVTPADH 246
            ||||||||:||||||||||.||||:||:||||.|..|.|....||..|    |.||||.:.||||
Zfish   145 FYGKFCAGAIDHISIRQLQLMLLKIALILGVEFHVNVEFVKLAEPPEDQENEGPGWRADIRPADH 209

  Fly   247 PVSHYEFDVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAKVEEISGVAFIFNQAF 310
            ||:.::|||::||||:||.|: ||||||||||||||||||.|:.|.|||||||||||||||||.|
Zfish   210 PVADFDFDVVVGADGRRNSLEGFRRKEFRGKLAIAITANFTNRNTTAEAKVEEISGVAFIFNQKF 274

  Fly   311 FKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPANVDTQKLHDYA 375
            |::|..:|||||||||||||.||||||||||.||:||||||.|..|...||...||:.:.|..||
Zfish   275 FQDLRQETGIDLENIVYYKDNTHYFVMTAKKQSLLDKGVIIHDYIDTEALLNSENVNQEALLVYA 339

  Fly   376 REAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQCLVGDSLLEPF 440
            ||||:::|.||:|.|::|:||..:|||||||||||:|:|.:..|..|.|..::..||||||||||
Zfish   340 REAADYATHYQLPTLDYAMNHCAQPDVAMFDFTSMYASENAALVRERFGHSVLVALVGDSLLEPF 404

  Fly   441 WPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQRDISAYTVDPA 505
            ||.|:|||||||::.|.|:.:|.|:..:| .|.|||:|||:||||.||||:.:.::...||:||.
Zfish   405 WPMGTGCARGFLAAFDTAWMVKSWAQGRN-PLEVLAERESLYRLLPQTTPENIAKNFDLYTIDPG 468

  Fly   506 TRYPNLNRESVNSWQVKH--------LVDTDDPSILEQTFMDTHALQTPHLDTPGRRKRRSGDLL 562
            |||||||...|...||::        |...:..|.:.:               |....||..::.
Zfish   469 TRYPNLNSNCVRPHQVRNNYICGEMKLCSLERASTIRR---------------PVNLARRESEIR 518

  Fly   563 PQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECNELS 627
            |  ..||.|...|...|:.: .:.:.:..:.||..|||||:|:||.||||.:..:.......:|:
Zfish   519 P--GRLLTWCQKQTEGYRDV-NVTDLTSCWSNGLALCALIHRFRPQLIDYDSLNEQDCARNLQLA 580

  Fly   628 FAVLERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRG-EIPHIKHPKMDFSDLRQKYRI 691
            |.|.|:|..|...::.|:.....|.:......||.:..:|||| .:|.        ||.::....
Zfish   581 FDVAEKEFGIKPFITGKELASGQEPDKSSMSIYLSKFYELFRGTPLPP--------SDSKRDDDA 637

  Fly   692 NHTHAQPDFS-----KLLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLLNIGGGA 751
            |:... |..|     |.|:.:|:.:.|..|          :.|.:.:...::||....|.
Zfish   638 NNEKC-PSGSPKSVYKSLSLQPRKRIPKND----------KKVEDTDAISKRRRKLNYLE----- 686

  Fly   752 AGAAAGVAGSGTGTTTQGQNDTPRRSKKRRQV-----------------DKTANILLLRTALCHE 799
                         .||:..|.:...|.:.|::                 |.||:..|.|.:.|:
Zfish   687 -------------ETTKSYNQSSSVSSEGRELKENKVKFMATQLLAKFEDSTASCSLRRQSDCN- 737

  Fly   800 ISNAISAFETINEEERQQRLQEIE--ENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLREGGE 862
                         .||..|...::  ::....:.|::.......:..:.|:.|:|...
Zfish   738 -------------GERPPRPPSLDMTDSSFFNIIKKKVPPPPPPKKQFPSIALVQHSD------- 782

  Fly   863 AGVAEDGTPFEDYSIFLYRQQAPVFNDRVKDLERKLLF----PDRERGDIPSALPRTA------- 916
                |...|     :||....:|: |.|.|.|......    |.....|..|:..|||
Zfish   783 ----ESSDP-----LFLSLHSSPL-NPRRKPLHPSHTHTHAQPPHTESDTESSGSRTAVLAVTAM 837

  Fly   917 -------DEQFSDR-----------IKNMEQRMTGRGGL--GGDKKPKDLMRA-IGKIDSN-DWN 959
                   :|:.|.|           .|:::::......|  |....|....|: .|.:|.. ...
Zfish   838 LQRLQRVEEEISQRKAQTQKAREFHKKSIKEKAVHLSALFSGEASAPDQTDRSQTGLLDKQLHEE 902

  Fly   960 VREIEKKIELSKKTEIHGPKGR----------------------EKVPKWSKEQFQA---RQHKM 999
            .||..|:: |...:.||.|...                      ...|.:..:|..:   ..|..
Zfish   903 KRESAKRL-LQPSSSIHLPSPNPLTTTSYPLTQSTATSCPPPILSSCPSFPIQQTSSSTVHHHSN 966

  Fly  1000 S-------------------------------------KPQRQDSREAE--------------KF 1013
            |                                     ..|||....::              |.
Zfish   967 SIIFHPIPECTAPIHLSFSFSSAFSLSSKSKSETCSGVNMQRQSESSSQMCDSCSSISSFTVRKQ 1031

  Fly  1014 KDIDQTIRNLDKQLKEGHNLDVGERGRNKVASIAGQFGKKDEA-----NSDEKNAGSSNATTNTN 1073
            .|:.|:            |.|:....:..|..::.:.|.:.:|     .:|.:...||:.|..:.
Zfish  1032 TDVPQS------------NEDLSATKQRTVGKVSLRVGARADALVTLYENDHRPQTSSSGTPPSI 1084

  Fly  1074 NTVIPKSSSKVALAFKKQAASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAF 1138
            ....|            |...:.|..||:.|:::|:.:.||...||.|.:|..|...||.||:.|
Zfish  1085 KREFP------------QTLGDVCHACKKRVFVVERLSAEGFHFHRECFRCETCRAPLRQGGHCF 1137

  Fly  1139 DRDDPQGRFYCTQHFRLPPKPLPQRTNKARKSAAAQPASPAVPPTAGSVPTAAATSEHMDTTPPR 1203
            ..:  :|:.||..||            ..|||......:..:..|...      .|.|..:..|.
Zfish  1138 HSE--EGKLYCKLHF------------AQRKSLVKNGRTETLHTTCND------GSHHGSSWTPE 1182

  Fly  1204 DQVDLLETSRA 1214
            ...|.|:...|
Zfish  1183 SHEDHLQAESA 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572	30/45 (67%)
		CH	563..>629	CDD:294029	21/65 (32%)
		LIM_Mical	1097..1153	CDD:188823	20/55 (36%)
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945
mical2a	XP_021333692.1	FAD_binding_3	90..>274	CDD:332373	134/183 (73%)
		CH	522..623	CDD:306753	31/101 (31%)
		LIM	1096..1150	CDD:295319	20/55 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	485	1.000	Domainoid score	I383
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001313
OrthoInspector	1	1.000	-	-		otm24310
orthoMCL	1	0.900	-	-		OOG6_103078
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810