DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mical and mical1

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	NP_001303659.1	Gene:	mical1 / 568573	ZFINID:	ZDB-GENE-081022-3	Length:	1214	Species:	Danio rerio

Alignment Length:	1542	Identity:	435/1542 - (28%)
Similarity:	626/1542 - (40%)	Gaps:	558/1542 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKFDARAAHRVYG 120
            ||:....|.|.::.......:|..:.:.|.....||.:||.::..|||:.||:|.|.||||..|.
Zfish    14 LFEGFVQAQTCKETQQNFTELCRHLQVDPKDYKHFYSKLKDRLNYWKAKDLWQKIDKRAAHPDYD 78

  Fly   121 KGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVITDLRNLGAKK 185
            :|.||...:.||:||||||||||||..||||:|||||||...|||||||||||.|.||.||||||
Zfish    79 QGKACHQNKCLVLGAGPCGLRTAIELALLGAQVVVLEKRSSFTRNNVLHLWPFTIKDLLNLGAKK 143

  Fly   186 FYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGGGWRAAVTPADHPVSH 250
            |||:||:|||.||||||||.:||||||.||||:|.||:|:...|||| ..||||.|:|..|||:.
Zfish   144 FYGRFCSGSIHHISIRQLQLILLKVALFLGVEVHTGVAFEGLNEPSG-SAGWRANVSPKSHPVAD 207

  Fly   251 YEFDVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAKVEEISGVAFIFNQAFFKEL 314
            ::|||.|.|.|.:.:.| |:.||.||||||.|||||:|:.|:.||:|:||||||.|:||.||:.|
Zfish   208 FQFDVFISAGGGKYVPDGFKIKELRGKLAIGITANFVNRHTKQEAQVQEISGVARIYNQQFFQAL 272

  Fly   315 YGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPANVDTQKLHDYAREAA 379
            ..:.|:||||||||||:||||||||||.||:.||||.:|.:|..:||||:||:.:.|.|||.||.
Zfish   273 QSEIGVDLENIVYYKDDTHYFVMTAKKASLLKKGVIKQDFSDADKLLAPSNVNQEALQDYAFEAC 337

  Fly   380 EFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQCLVGDSLLEPFWPTG 444
            :|||::.:||||||.||.|:.||||||||.|..||.:..|..|.|.||:..||||||:|||||.|
Zfish   338 DFSTEHLLPNLEFAKNHKGQADVAMFDFTCMQRAESASLVKERNGKRLLIGLVGDSLVEPFWPLG 402

  Fly   445 SGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQRDISAYTVDPATRYP 509
            :|.|||||.:.|||:.::.|.... ..:.|||:|||:|:||:||||:...::..||::||:||||
Zfish   403 TGIARGFLGAFDAAWMVRSWGKGV-QPMEVLAERESVYQLLSQTTPENTSKNYMAYSIDPSTRYP 466

  Fly   510 NLNRESVNSWQVKHLVDTDDPSILEQTFMDTHALQTPHLDTPGRRKRRSGDLLPQGATLLRWISA 574
            |:|..|:...|||.|.:.      |:.....:.|:.|.:....|:     |.:.:...||.|...
Zfish   467 NINLSSIKPRQVKRLYEA------EEQESKPNKLKKPDIKAKPRK-----DSMKRLEELLSWCQK 520

  Fly   575 QLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECNELSFAVLERELHIDR 639
            ....|:.: ::|:.|:.:|:|..|||||:.:||:|:|.:|..:.:.::.|:|:|.::|:|..|..
Zfish   521 NTVGYEHV-KVKDLSESWRSGLALCALIHSFRPELVDMSALDEYNIIKNNKLAFDLMEKEFGITP 584

  Fly   640 VMSAKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSDLRQKYRINHTHAQPDFSKLL 704
            :|.....:...:::....:.||.||
Zfish   585 IMRPGDMMTCGKIDQLSMVVYLTQI---------------------------------------- 609

  Fly   705 ATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLLNIGGGAAGAAAGVAGSGTGTTTQG 769
                                  |:.|.|:
Zfish   610 ----------------------RNALTEK------------------------------------ 616

  Fly   770 QNDTPRRSKKRRQVDKTANILLLRTALCHEISNAISAFETINEEERQQRLQEIEENRQERMSKRR 834
              |||...                       ||.:|                        :|::|
Zfish   617 --DTPAAQ-----------------------SNTLS------------------------LSRKR 632

  Fly   835 QQRYHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDYSIFLYRQQAPVFNDRVKDLERKLL 899
                                        :.||           ||
Zfish   633 ----------------------------SAVA-----------FL-------------------- 638

  Fly   900 FPDRERGDIPSALPRTADEQFSDRIKNMEQRMTGRGGLGGDKKPKDLMRAIGKIDSNDWNVREIE 964
                      :.|.|.:.::..||:.::
Zfish   639 ----------NTLKRNSLQRHKDRLASV------------------------------------- 656

  Fly   965 KKIELSKKTEIHGPKGREKVPKWSKEQFQARQHKMSKPQRQDSREAEKFKDIDQTIRNLDKQLKE 1029
                          ||                     |::|:.:|.|:.||:
Zfish   657 --------------KG---------------------PRQQNMKEKEEKKDV------------- 673

  Fly  1030 GHNLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTNNTVIPKSSSKVALAFKKQAAS 1094
                                   |:|:.|.|                              .:|.
Zfish   674 -----------------------KEESLSSE------------------------------TSAC 685

  Fly  1095 EKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQH------- 1152
            |.|.|||:.:|::|:.:.||...||:|..|..|.:.||.|||:|..|:  |||||..|
Zfish   686 EPCYFCKKHLYVVERESAEGKFFHRSCFNCFQCGSTLRQGGYSFHSDN--GRFYCELHSLAEEEE 748

  Fly  1153 --------------------------FRLPPK------------------------PLPQRTNKA 1167
                                      ...||.                        |.|.:....
Zfish   749 GDEGHGGAQNHTENGSKEDKNGETTAASSPPAHLSIKRKGSYKISVDPDFDESTEFPAPDQDEPP 813

  Fly  1168 RKSAAAQPASPA------------------VPPTAGS-------------------VPTAAATSE 1195
            ....:.||..|:                  ||...||                   :|..|   |
Zfish   814 DLEESHQPPKPSELSAENTNMENQQHNINPVPAPRGSRAPLPKPRTVHNVVHEPCNIPEEA---E 875

  Fly  1196 HMDTTP-PR-----------DQVDLL-----ETSRANASADAMSDDEANVIDEHEWSGRNFLPES 1243
            .:...| |:           ::||||     ..:|.::||.:.|.......:|..|||.....:|
Zfish   876 QIPEEPKPKPSLRKLQQSEEEKVDLLSQDSDSETRGSSSAASTSSSSKQHEEEGYWSGGTTWGKS 940

  Fly  1244 NND----------SQSELSSSDESDTESDSEMFEEADDSPFGAQTLQL----------ASDWIGK 1288
            :.:          |:..|..:..|........|     ||:...:.:|          |......
Zfish   941 HREQRNRPCIRRKSEPPLPLTGHSQHGKMRSKF-----SPWNLSSPRLQQRFSVHRVPAGQSQPD 1000

  Fly  1289 QYCEDSDDSDDFYDSSEDDGKD---DTEGEEFKKARELRRQEVRLQPLPANLPTDTETEKLKLNV 1350
            ||..:.|:.||..:..||...:   |.||.:|:.:...:|...|::.|
Zfish  1001 QYVSEDDNEDDEDEDEEDLQAEHYLDCEGADFEFSDSEKRNLKRMKTL----------------- 1048

  Fly  1351 DNKENMADRSSLKSGNSFESARSQPSTPLSTPTRVEME----QLER--------NAPRKFSSEIE 1403
            :.|..|.:........|.:....:...     |..|:|    :|||        ..|......||
Zfish  1049 ERKAKMTEIQRFHKAQSIQRRLEEIEV-----TFKELEEKGVELERALRGETGTGDPEIIDQWIE 1108

  Fly  1404 AISEKLYHMNNMVKMNKDLEVLA-------KENLVKSDILRKLTLKE 1443
            .:.||    ||::....||.|.:       |:::::.::.|.:.:.:
Zfish  1109 LVQEK----NNLLSEESDLMVASRQLELEDKQSMLEMELRRYMEMDD 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572	31/45 (69%)
		CH	563..>629	CDD:294029	20/65 (31%)
		LIM_Mical	1097..1153	CDD:188823	26/88 (30%)
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945
mical1	NP_001303659.1	Monooxygenase domain. /evidence=ECO:0000250\|UniProtKB:Q8VDP3	1..488		271/481 (56%)
		NAD_binding_8	90..>133	CDD:290186	35/42 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..505		3/26 (12%)
		CH	512..609	CDD:278723	27/97 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..676		11/134 (8%)
		LIM_Mical	688..742	CDD:188823	25/55 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	747..1019		43/279 (15%)
		DUF3585	1062..1193	CDD:288945	19/99 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1194..1214
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9366
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001313
OrthoInspector	1	1.000	-	-		otm24310
orthoMCL	1	0.900	-	-		OOG6_103078
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810