DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mical and micall2b

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	NP_001299826.1	Gene:	micall2b / 556298	ZFINID:	ZDB-GENE-030131-5803	Length:	783	Species:	Danio rerio

Alignment Length:	864	Identity:	166/864 - (19%)
Similarity:	300/864 - (34%)	Gaps:	221/864 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   981 REKVPKWSKEQFQARQHKMSKPQRQDSREAEKFKDIDQTIRNLDKQLKEGHNLDVGERGRNKVAS 1045
            :|.:.:.::..|:..:.::..|...|:.:....|..|:.  ::...:.:.:|.   ..||:.:..
Zfish    55 KENIYENNQRAFEVAEKELGIPALLDAEDMVALKVPDRL--SILTYVSQYYNY---FHGRSPIGG 114

  Fly  1046 IAGQFGKKDEANSDEKNAGSSN-----------ATTNTNNTVIPKSSSK----VALAFKKQAASE 1095
            :.|.  |:....|:|..:|..|           .....|.|..|.:.:|    ...|.|....|.
Zfish   115 MGGI--KRPAEESNEAPSGKKNPPVIAKVLPSPKPATENKTPKPANENKREVLTERANKSSTPSS 177

  Fly  1096 KCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFRLPPKPL 1160
            .|..|.|.|:|:::..|:|.:.||||.||..|.|.|..|.|...::  .|.|.|..|..: .|||
Zfish   178 NCSVCNQHVHLVQRHLVDGKLYHRNCFKCKECSTILLSGTYKAGKE--PGTFICKTHTSI-EKPL 239

  Fly  1161 PQR---TNKARKSAAAQPASPAVPPTAGSVPTAAATSE------HMDTTP-------PRDQVDLL 1209
            ..|   .:|.:.:...:|...|:..:.|.......||:      ..|..|       |...|.|.
Zfish   240 TTRFTAPSKTQSTFINKPDQSALGGSTGKASLNTNTSKLGWLANKSDRIPMRGFTDTPTPAVQLT 304

  Fly  1210 ETSRANASADAMSDDEANVIDEHEWSGRNFLPESNNDSQSELSSSDESDTESDSEMFEEADDSP- 1273
            .|::|..:.|..:....        ||    |.|..:|...:|::.:.:.|:....||.:..||
Zfish   305 PTAKATPTPDTTTAKSP--------SG----PRSATESLKPVSNTVQKNQEARMRFFESSSSSPS 357

  Fly  1274 --------------------FGAQT-------------------LQLASDWIGKQYCEDSDDSDD 1299
                                .|.:|                   |....||.
Zfish   358 SVVPASKSTSSYTSTTSVSTAGVKTTAPETTTPRVPAGAGKGRVLLRVGDWA------------- 409

  Fly  1300 FYDSSEDDGKDDTEGEEFKKARELRRQEVRLQPLPANLPTDTETEKLKLNVDNKENMADRSSLKS 1364
               .|:|..|:....:|.:||:.:..:.|                  |::.|:..:.|..:.||:
Zfish   410 ---KSQDTEKEKENEKEKEKAKAVIGKMV------------------KVDKDSNSSSASPAGLKA 453

  Fly  1365 GNS-FESARSQPSTPLSTPTRVEMEQLERNAPRKFSSEIEAISEKLYHMNNMVKMNKDLEVLAKE 1428
            .:| .....|....|..   ||.::.||.:.                            |..|..
Zfish   454 NSSNVPPLESNAKAPFG---RVRLKALEASG----------------------------ETTAPA 487

  Fly  1429 NLVKSDILRKLTLKEKWLAENAAIAAGQKVTPTPSATAPGLQPKSKFDEKFEKVVSPPQPVVEPK 1493
            ..|.|      .:|||.|:.|         ..|||:.:          ::.:.|.|..:.:::|.
Zfish   488 TTVPS------WMKEKSLSRN---------VNTPSSNS----------KENDTVPSDWRSMLKPV 527

  Fly  1494 PKPVIDFNLDELKPRKPNFEERPKEQLPRPESLKKPPQQKPKGSSTNVSRSNSLKSNASNGSPKV 1558
            .|||.:.....|..|             |.|::..|....|..|:|.:|.|.|     |:.:|..
Zfish   528 SKPVSNLESKGLPAR-------------RTEAVSSPKTSVPASSTTTISISIS-----SSKTPLT 574

  Fly  1559 KKAPISNNSKMQIEGILGTLRKIQSQNSSDQDEDMDVDEDVERKPNKELNSKLKEIQASSFAGTM 1623
              .|:.|.||......:..:....::............||:: |..||:...:.|::....
Zfish   575 --TPLKNGSKPNDSSSVFPVSPSGTETHKSHKPGYIPKEDIQ-KELKEIEMNMNELEKKGV---- 632

  Fly  1624 DHIKSQLTMPTVSAQAPPSMD--LSKYFPNQKQEKSSTSSTNKNQVTLKDVNLAKYFPSSPAPQR 1686
             .::.||.......:....|:  :..:|...:.::......::.....:..:|.:..||..|..|
Zfish   633 -ELEKQLRQCDEDGEEDALMNDLMVDWFTLIRNKQVYMRRESELVYIARTQDLEEEQPSVDAELR 696

  Fly  1687 RTVETVADRLK----KSQTEAALAKTKLLEDQANNQAEKTKKE-VEKEGESKKITKKVA--DSKA 1744
            |.:|. .|.||    :.:.|..:||...:.:..|...|...:: :.:|.|.:::.|.:.  |.|.
Zfish   697 RLMEK-PDHLKTLWDRKREEELMAKLVEIVNDRNAIVEGLDEDRLREEEEDEQLNKMMQSFDMKK 760

  Fly  1745 VPPKRQASLDT-FSLREHQ 1762
            ...|:.:.:.. ||:|:.:
Zfish   761 EKVKKMSPVTRWFSMRKRR 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572
		CH	563..>629	CDD:294029
		LIM_Mical	1097..1153	CDD:188823	21/55 (38%)
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945
micall2b	NP_001299826.1	CH	5..102	CDD:278723	6/48 (13%)
		LIM_Mical_like_1	179..233	CDD:188828	21/55 (38%)
		DUF3585	609..741	CDD:288945	25/138 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000