DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mical and LIMA1

DIOPT Version :10

Sequence 1:NP_001247015.1 Gene:Mical / 41225 FlyBaseID:FBgn0053208 Length:4743 Species:Drosophila melanogaster
Sequence 2:NP_001107018.1 Gene:LIMA1 / 51474 HGNCID:24636 Length:760 Species:Homo sapiens


Alignment Length:320 Identity:52/320 - (16%)
Similarity:113/320 - (35%) Gaps:94/320 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 INNLHNVIEEL-----RNKLATVESKNKD---LETK-----FSENQDYLKNAKDKVTFLENQLNS 290
            :::||..:.:|     .||...:|..|||   |.|.     |.:.|..|            ::..
Human    84 MDDLHCTVNKLFGKKCTNKTDNMEKDNKDKWNLTTTPFYHGFKQMQSCL------------EVTE 136

  Fly   291 DAHEEVKSTAVRALEVKLGLANNSIRQAEAEKQQLQEANWYANERVGKLEQENGYLKGITEQLKA 355
            ....:|...|..||.:|...||.::  .:.:..|.....:|.|            :...|.|:.|
Human   137 ACVGDVVCNAQLALYLKACSANGNL--CDVKHCQAAIRFFYQN------------MPFNTAQMLA 187

  Fly   356 RADTSHAEKMLKDSEKRVWE--------------------INEEKSKLEWRLGELSQWWNDAKWK 400
            ..|.:.::...:.|::.:..                    .|:|..:..:|..: ::.|.....|
Human   188 FCDCAQSDIPCQQSKETLHSKPCALNIVPPPTCLSVIHTCRNDELCRTHYRTFQ-TECWPHITGK 251

  Fly   401 VGELESSVAL--QRNLLDTANSKIQSLNDQLIQEVRSHSSTMTIPTDGFTISQSNQGTWNLANG- 462
            ..|.|:.:::  :::|..:.:...::      ..:.:..:.:.:|.....::|:.:....:... 
Human   252 CHEDETCISMLGKQDLTCSGSESCRA------AFLGTFGTVLQVPCACRGVTQAEEHVCMIFQHM 310

  Fly   463 -SNQPCFTGAIPSIPLVSALPFAGANPFIFGGANEGRNVTLTISNTEQEVYLTG--SFIN 519
             .::.||....|::..:|:.              |.:|        .:|:.|||  ||.|
Human   311 LHSKSCFNYPTPNVKDISSY--------------EKKN--------SKEITLTGFNSFFN 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MicalNP_001247015.1 UbiH 128..>263 CDD:440419 9/31 (29%)
CH_SF 567..669 CDD:469584
LIM_Mical 1097..1153 CDD:188823
PRK10819 <1450..>1557 CDD:236768
bMERB_dom 4592..4705 CDD:463467
LIMA1NP_001107018.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..131 13/46 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..182 9/49 (18%)
Required for interaction with NPC1L1. /evidence=ECO:0000250|UniProtKB:Q9ERG0 164..166 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..264 7/53 (13%)
LIM_Eplin_alpha_beta 391..443 CDD:188869
Required for interaction with MYO5B. /evidence=ECO:0000250|UniProtKB:Q9ERG0 494..514
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..710
Blue background indicates that the domain is not in the aligned region.

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