DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mical and Rassf

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	898	Identity:	173/898 - (19%)
Similarity:	283/898 - (31%)	Gaps:	269/898 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  3820 GYMEYIEAEPKKTTRKAAPPSSYPGNLPPLMTKRD---EKLGVDYIEQGAYIMHDDAKT------ 3875
            |:...:|:......:.|..|:....|.|||  .||   .||.|       |....|.|:
  Fly    67 GHGTRVESHKSYGVKGAQKPTGAQANGPPL--PRDHLESKLKV-------YNQFYDNKSLEIRSR 122

  Fly  3876 PVN-----EVAPAMTQSLTDSITLNELDDDSMIISQTQPTTTEESEALTVVTSPLDTSSPRVLDQ 3935
            .||     |.|..:...:...|.|.|.||..:::.:.......::
  Fly   123 EVNNRLVLEGALRVYWGVQGVIHLKEDDDQRILVRKRNSCRVSKA-------------------- 167

  Fly  3936 FASMLAAGKGDSTPSSSEQQPKTSTVTSSSTGPNSSTTGNVSKEPQEEDLQIQFEYVRALQQRIS 4000
                       :..|||:::.:    .|.|..|.::||..|.:...:..|.....:.......||
  Fly   168 -----------ANESSSDKENE----ASESLAPPTTTTAEVDQLSTDVSLSESMTFDSCSLNEIS 217

  Fly  4001 QISTQRRKSSKGEAPNLQLNSSAPVIESAEDPAKPAEEPLVSMRPRTTSISGKVPEIP------- 4058
            ::.|....:|.....|.:..::..|....||..             ||..||.:.|.|
  Fly   218 ELPTTPEDASANTTANSKEQTNGNVCNDDEDTT-------------TTDSSGTLVEAPTASTSCV 269

  Fly  4059 --TLSSKLEEITK-------------ERTKQKDLIHDLVMDKLQSKKQLNAEKRLHRSRQRSLLT 4108
              ||.|||:.:.|             .|...||.|::.:..||.|.:..:.......|.:.:..|
  Fly   270 SSTLPSKLDRLEKLDWDDIDDLLQVERRHNDKDRIYETMPVKLPSSQSSSDSSPSKTSTETTTTT 334

  Fly  4109 ---SGYASGSSLSPTPKLAAACSPQDSNCSSQAHYHASTAEEA-----------PKPPAERPLQK 4159
               |..::.::.|.|.....|.....:|.::|.....||.|.:           .||......::
  Fly   335 ESSSTQSASTNTSSTDDFMTATGSLTANTNTQNTTTVSTTETSLDNFETCDDATLKPIDFEDFKR 399

  Fly  4160 SATSTYVSPYRTVQAPTRSADLYKPRPF--SEHIDSNALAGYKLGKTASFNGGKLGDFAKPIAPA 4222
            |....||:...:...|.... |.:.:|.  |...||..|.|.....:.|||   .....:.|.|.
  Fly   400 SVHQDYVNGANSFTEPNEGT-LKRNQPIDPSRIHDSLKLYGENSAMSKSFN---CEHALRSIDPT 460

  Fly  4223 RVNRGGGVATADIANISASTENLRSEARARARLKSNTELGLSPEEKMQLIRSRLHYDQNRSLKPK 4287
            .:|        |..|:.:|..:..|..|..|..||.:....|.::|..       |.|.|.|..|
  Fly   461 LIN--------DTMNLRSSVGSPHSAQRQYALQKSGSATVTSRDQKKP-------YQQGRQLFEK 510

  Fly  4288 QLEEMPSG-------------DLAARARKMSASKSVNDLAYMVGQQQQQQVEKDAVLQAKAADFT 4339
            .:....||             :...|.::|:..:. :|:     .|:..|::.|..
  Fly   511 GINRSKSGPSCFVYSDSDDDDEATLRPQRMATIRR-SDI-----PQRYIQIQMDCY--------- 560

  Fly  4340 SDPNLASGGQEKAGKTKSGRRPKDPERRKSLIQSLSSFFQKGSGSAASSSKEQGGAVAAVHSEQS 4404
                                 ||:.....|          :|..|.|.:.....||.|.....|:
  Fly   561 ---------------------PKENVAAAS----------EGESSRADAPSITSGAAAGDELTQT 594

  Fly  4405 ERPGTSSSGTPTISDAAGGGGGGGGVFSRFRISPKSKEKSKSCFDLRNFGFGDKDMLVCNAASPA 4469
            |...|:|.|.    |...|.|..|     ..::                    :|.:|.......
  Fly   595 EDLYTASEGV----DGPDGDGSAG-----LHVT--------------------EDGVVLRRPPRT 630

  Fly  4470 GATSASQKN---HSQEYLN---TTNNSRYRKQTNTAKPKPESFSS-------------------- 4508
            ||::..:::   .|:..|.   :.|...|.::|:...|...|..|
  Fly   631 GASAIKRRSGNRRSRTKLKRRCSINGHYYNRETSFFTPPYGSQMSVWVSSMVTTTEVINLVLEKY 695

  Fly  4509 ---SSP---QLYIHKPHHLAAAHPSALDDQTPPPIPPLPLN-----------YQRSDDESYANET 4556
               |||   .|:|.:.:    .....|.|...|.|..:.|.           ..|..|| .:||.
  Fly   696 KVDSSPGNFSLFIVRDN----GEQKRLKDDEYPLITRVTLGPHEDVARIFLVDSRKTDE-ISNEV 755

  Fly  4557 REHKKQRAISKASRQAELKRLRIAQEIQREQEEIEVQLKDLEARGVLIEKALR 4609
            .:...   :|....:|.|:  |..||:.||..:|:.:..:|..|.|...::|:
  Fly   756 AQFLN---LSLPECRAILE--RYDQELAREVAKIKERYAELRRRIVSRMESLK 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572
		CH	563..>629	CDD:294029
		LIM_Mical	1097..1153	CDD:188823
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945	4/18 (22%)
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	14/87 (16%)
		Nore1-SARAH	762..799	CDD:293125	12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810