DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mical and mical3a

DIOPT Version :9

Sequence 1:NP_001247015.1 Gene:Mical / 41225 FlyBaseID:FBgn0053208 Length:4743 Species:Drosophila melanogaster
Sequence 2:XP_021323435.1 Gene:mical3a / 402881 ZFINID:ZDB-GENE-050126-2 Length:2522 Species:Danio rerio


Alignment Length:2664 Identity:745/2664 - (27%)
Similarity:1122/2664 - (42%) Gaps:635/2664 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 LFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKFDARAAHRVYG 120
            |||....|||.:..|...:.:|:.:.|:|:....||.:||:|:..|||:|||.|.|.||:|:.|.
Zfish    19 LFDRFVQATTCKGTLKAFQELCDFLELKPNEYRVFYHKLKSKLNYWKAKALWAKLDKRASHKEYK 83

  Fly   121 KGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVITDLRNLGAKK 185
            ||.||..|:.|:|||||||||||||...||||||:|||||..:||||||||||.|.|||.|||||
Zfish    84 KGRACANTKCLIIGAGPCGLRTAIELGFLGAKVVLLEKRDAFSRNNVLHLWPFTIQDLRGLGAKK 148

  Fly   186 FYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGG----GWRAAVTPADH 246
            ||||||||:||||||||||.||||||||||:|||..|.|...:||..|..    ||||.|.|..|
Zfish   149 FYGKFCAGAIDHISIRQLQLMLLKVALLLGIEIHVNVEFKGLIEPPEDQENERIGWRAEVHPRTH 213

  Fly   247 PVSHYEFDVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAKVEEISGVAFIFNQAF 310
            ||:..||||:|||||:||.|. ||||||||||||||||||||:.|.|||||||||||||||||.|
Zfish   214 PVNELEFDVIIGADGRRNTLSGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKF 278

  Fly   311 FKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPANVDTQKLHDYA 375
            |::|...|||||||||||||:||||||||||.||::||||:.|.||...||:.||||.:.|..||
Zfish   279 FQDLREATGIDLENIVYYKDDTHYFVMTAKKQSLLEKGVILHDYADTEMLLSRANVDQKALLSYA 343

  Fly   376 REAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQCLVGDSLLEPF 440
            ||||:|||.:|:|.|:||:||||:|||||||||.|:|:|.:..|..|.|.:|:..||||||||||
Zfish   344 REAADFSTNHQLPKLDFAINHYGQPDVAMFDFTCMYASENAALVRQRNGHKLLVALVGDSLLEPF 408

  Fly   441 WPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQRDISAYTVDPA 505
            ||.|:|.|||||::||:|:.::.|:: .:|.|.|||:||||||||.||||:.:.::.|.|:|||.
Zfish   409 WPMGTGIARGFLAAMDSAWMVRSWAH-GSSPLEVLAERESIYRLLPQTTPENVSKNFSQYSVDPT 472

  Fly   506 TRYPNLNRESVNSWQVKHLVDTDDPSILEQTFMDTHALQTPHLDTPGRR----KRRSGDLLPQGA 566
            |||||::...|...||:||:||.:...|.....:.....||.|.   |.    :::..:.:.:.:
Zfish   473 TRYPNISLHQVRPNQVRHLLDTGETRDLRVDLENVVNSSTPKLT---RNEILLEKQLQESIVRSS 534

  Fly   567 TLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECNELSFAVL 631
            .||.|...|...|:.: .:.:.:..:::|..|||||:||||||||:.:..:....:.|:|:|.|.
Zfish   535 KLLNWCQRQTEGYRGV-SVSDLTTSWKSGLALCALIHRYRPDLIDFESLDEKDVEKNNQLAFDVA 598

  Fly   632 ERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRGEIP-----------------HIKHPK 679
            |||..|..:|:.|:...:.|.:....:.||.|..::|:..:|                 ..|.|.
Zfish   599 EREFGISPIMTGKEMSVVVEPDKLSMVMYLSQFYEMFKDTVPPGENQNLSPEEKAALIASTKSPI 663

  Fly   680 MDFSDLRQKYRINHTHAQPDFSKLLATKPKAKSPMQ-DAVDIPTTVQRRSVLEEERAKRQRRHEQ 743
            ...|.|.|...|:...           .||.|...: |.:.......:....|:|..:|..|.::
Zfish   664 SFLSKLGQSIAISRKR-----------NPKDKKEKELDGLGKRRKTSQAGQSEDEELQRANRDDR 717

  Fly   744 LLNIGGGAA------GAAAG----VAGSGTGTTTQGQNDTPRRSK-KRRQVDKTANILLLRTALC 797
             .:|....|      .|||.    |....|....:.:.:.|.:|. .:||.|...::.|:.|   
Zfish   718 -PSIATALAERKIDSAAAANNNNKVKSMATQLLAKFEENAPTQSTGLKRQGDSMPDLGLILT--- 778

  Fly   798 HEISNAISAFETINEEERQQRLQEIEENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLRE--- 859
                 ...|...:||   ..||..:...|     |||.|...|....||.....|...:.:|   
Zfish   779 -----PSPAAAPLNE---SVRLAPVPAWR-----KRRTQLQEQMSFRYKEKLKCQTLPITQEQAS 830

  Fly   860 -GGEA-------------------------------------GVAEDGTPFEDYSIFLYRQQAPV 886
             |.|.                                     ||.:....|:|.|:..:....| 
Zfish   831 SGTEVLRSCPKKTILLSSSSPSSSSFSSSFPPHAQSVIHKCNGVGDGENRFQDLSVCYWEDNLP- 894

  Fly   887 FNDRVKDLERKLLFPDRERGDIPSALP-RTADEQFSDRIKNMEQRMTGRGGLGGDKKPK-DLMRA 949
                              ..|.|..:. |:..|    |.:.:..|..|:    .|:|.| .:|:.
Zfish   895 ------------------NVDKPEPIHIRSIQE----RAETLVARFKGK----ADRKDKPQVMKK 933

  Fly   950 IGKIDSNDWNVREIEKKIE--LSKKTEIHGPKG--------REKVPKWSKEQFQARQHKMSKPQR 1004
            ..:.....|.:.......|  .|...:.|..||        ...:|...:...:...|...||.:
Zfish   934 PSRFFIEQWFLTHGLSPDEPVFSSDPQHHQQKGVLCPDDHVPLHIPSIQERAERLASHFKDKPAK 998

  Fly  1005 QDSREAEKFKDIDQTIRNLD----------KQLKEGHNLDVGERGRNKVASIAGQFGKKDEANSD 1059
            ..|::.......:|..|..|          ...:: |.:.:...|   |:|:|.|...:.:|..|
Zfish   999 PKSKKKSSLLLTEQWSRARDVSSASPLHSPSSFRQ-HCVKMYTGG---VSSLAEQIANQLQAKDD 1059

  Fly  1060 EKNAGSSNATTNTNNTVIPKSSSKVALAFKKQ-----AASEKCRFCKQTVYLMEKTTVEGLVLHR 1119
            .:                |....:...:|:|:     ..|:.|.||::.||:||:.:.||...||
Zfish  1060 PR----------------PMLEKRDLGSFRKEFPQNIGGSDVCFFCRKRVYVMERLSAEGKFFHR 1108

  Fly  1120 NCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFRLPPKPLPQRTNKARKSAAAQPASP---AVP 1181
            :|.||.:|.|.|||..||||.:|  |:|||..|:......:.||...|..:|.|....|   ||.
Zfish  1109 SCFKCDYCGTTLRLSSYAFDVED--GKFYCKPHYCYRLSGVAQRKRPAPAAAPANAKEPQVLAVS 1171

  Fly  1182 PTAGSVPTAAATSE----------------------HMDTTPPRDQVDLLETSRANASADAMSDD 1224
            |.....|..|.|::                      .:..||.|.:::       |.....|.::
Zfish  1172 PNTVDAPGQAITTQTPAERRPSETEVNGVTEPSVAKRLKGTPERIELE-------NYRLSMMREE 1229

  Fly  1225 EANVIDEHEWSGRNFLPESNNDSQSEL---SSSDESDTESDSEMFEEADDSPFGA----QTLQLA 1282
            |...:.|...:..|.  .|..|..:::   |||.|||.|.:.|..|.|..|..|.    :.::|.
Zfish  1230 ELEEVPEETLAEHNL--SSVLDKATDIEEGSSSSESDMEEEDEDAEAAGPSDLGGVPWKEAVELH 1292

  Fly  1283 SDWIGK---------------QYCEDSDDSDDFYDSSEDDGKDDTE-GEEFKKARELR------- 1324
            :...|:               :..||.::.:|..|..|::.::.:| |:.|...|||:       
Zfish  1293 AKLKGESDPGADDDGLHDGDGEMDEDEEEEEDEEDEDEEEEEESSEAGDYFPWERELQSGLWLEN 1357

  Fly  1325 ---RQEV------RLQPLPANLPTDTETEKLKLNVDNKENMADRSSLKSGNSFESARSQPS--TP 1378
               .::|      .||...|..|.|      .|::..:.:.|:  .:....|.....||||  |.
Zfish  1358 LANEEDVSVFKARNLQIQQAIHPVD------PLDIQMESHQAE--GVLEMPSVSPLGSQPSLNTQ 1414

  Fly  1379 LSTPTRVEMEQLERNAPRKFSSEIEAISEKLYHMN-------------------------NMVKM 1418
            |:.||       ...||...|...||:...|..|:                         :...:
Zfish  1415 LTQPT-------SSTAPSHKSVRHEAVRAWLDSMSGEPCEEDDDPEAEAGSPDFEPGTEIDQEDI 1472

  Fly  1419 NKDLEVLAKENLVKS------------------DILRKLTLKEKWLAENAAIAAGQK-------- 1457
            ..|.|..|:...:..                  :...|.:...:.|..:..::..||        
Zfish  1473 PSDAEAEARSRCIDEVVTLPVDNDKTESQGQVFNTAEKTSANPRELIVDVVLSPIQKPALPIEEV 1537

  Fly  1458 --VTPTPSATAPGLQ--PKSKFDEKFEKVVSPPQ---------PVV----------EPKPKPVID 1499
              |:|.....:||.:  |:....:|.::.:.|||         ||.          :|.|:|   
Zfish  1538 HEVSPVVLVKSPGARFFPEPYLPDKVKQNIPPPQSPDVKTPHSPVAQIIALSPICSQPVPQP--- 1599

  Fly  1500 FNLDELKPRKP------------------NFEERPKEQLPRPESLKKPPQQKPKGSSTNVSRSNS 1546
               ....|:.|                  ..:.:|..:.|.|.|...|.:.:|..:.|:...:..
Zfish  1600 ---GTASPKSPVQPQPCACSPTGNPLSPICTQSQPCNEPPSPLSTSSPVRTQPVPAVTSTPLAKP 1661

  Fly  1547 LKSNASN-----GSPKVKKAPISNN---SKMQIEGILGTLRKIQSQNSSDQDEDMDVDEDVERKP 1603
            ...|.:|     .:|::||..:...   ...:|...||.....:|:.:        |::.:.:.|
Zfish  1662 ASENRTNEHLKDSTPELKKTDLIEEFWLKSAEIRKSLGLTPLERSKTA--------VEKSIVKTP 1718

  Fly  1604 NKELNS-------KLKEIQASSFAG--TMDHIKSQLTMPTVSAQAPPSMDLSKYFPNQKQEKSST 1659
            ..|.:|       .|.|.|..:|.|  .:..|...|....:|...|.|..      ::|::.||:
Zfish  1719 TPESSSPKSYTPEDLSEEQKPTFTGRSIIRRINITLEGQVISPVEPKSNG------SEKKDLSSS 1777

  Fly  1660 SSTNKN-QVTLKDVNLAKYF----------PSSPAPQRRTVETVADRLKKSQTEAALAKTKLLED 1713
            |....| .||......:..:          ||||.|.....|....:.||||    ::...|||.
Zfish  1778 SGLGLNGSVTTSQTAASDSYNNSDSTMLTPPSSPPPPPPREEPACLQNKKSQ----VSWDNLLEG 1838

  Fly  1714 QANNQAE----KTKKEVE-KEGESKKITKKVADSKAVPP----------KRQASL---------- 1753
            ....::|    |.:..|. .:.:.|.:|..|...:..||          .|:..:          
Zfish  1839 TEEPKSETMPIKPRTPVSPPQPKQKPVTAPVPTPRTNPPVVMRVKEPNKPRREEVRKSFVECVDE 1903

  Fly  1754 --------DTFSLREHQMDGALDLTKKKGPTKASAGVKKP------AKSGSTTSVTKATATSKG- 1803
                    ||:..|.....|   |.|...|..:.....||      |......::...:.|:|| 
Zfish  1904 IPFADDVEDTYDDRTPDASG---LEKFYTPPTSKVNRDKPPLHLALAMENGKPNIPGVSRTAKGS 1965

  Fly  1804 -------------------KTIK-------IVKKI-------VPKGTKAKKAAEAAQESAVVEAP 1835
                               |::|       :.|::       |.||..||.|.:..:...  ::.
Zfish  1966 QHFSPEAKEIAEERMRAREKSVKSQALKDAMAKQLTKMKDSEVAKGAVAKVAWDIPETKG--KSK 2028

  Fly  1836 PEKKPPKDEAERILD-----EILGDGEYRSPSSEYQRLFQDEKSPSDLSDNIDRILEESGLDVEL 1895
            .:.|..||.|.:.|:     :.|.|..:.:|||:    ..|....|..|....:..:.|.|    
Zfish  2029 KQSKAQKDSAVKALESKKQADTLPDRFFSTPSSK----ALDSSVTSSESSTGGKSKKRSSL---- 2085

  Fly  1896 GLPKRSSKKLVKTKSLGEGDFDMKPSKER------LTGVQNILKRFESMSSVTSQNS-------- 1946
             ...|.:||..|.|:......:..|.|.:      .:|.:...|:.:..|..::.:|        
Zfish  2086 -FSPRKNKKEKKAKNERLSSTEETPPKHKSLWKAVFSGYKKDKKKKDDKSCPSTPSSSTTGDSGK 2149

  Fly  1947 ------DEQAAFKLRR--MESTTSNLSS---LTRSRESL-----VSVSDSMSDLEKTMDYLRNEW 1995
                  |..:..:|||  ..|..|:||.   |.||.:..     |.:.|.:|||:|  :.::.|.
Zfish  2150 KKDSPLDRSSDLRLRRNLSFSEDSDLSCDDVLERSSQKSKGDRHVDLFDLVSDLKK--EAIKEEK 2212

  Fly  1996 RNEATNFLQKKR----DKFYAKKEEQEKESKILAKPDPLDNLPVQYRDSKLAKFFGLAASKSPEN 2056
            ..|......|:|    :|...:..|:|.|.::..|       .|:.:|.:..|      .|..|:
Zfish  2213 AKEKAKDRAKERGRVTEKGKERSRERENEKRVKEK-------MVKMKDVEREK------GKEEES 2264

  Fly  2057 RKSP--IKKKKSPSKTPKVTKANNSLEEL-AKISNVRQTKKAQPKTLKPVEVKPLKPASPVPDDF 2118
            ...|  :..|:|     ..||...:.||| ||::  |:.:||..:..|..|:|.|..|..:....
Zfish  2265 VYVPHALAFKRS-----YATKKTYTEEELNAKLT--RRVQKAARRQAKQEELKRLHRAQMIQRQL 2322

  Fly  2119 EILDLLEKATEAKE----LERS-KTKSPAVESISQTPKE--------------AIVEISLPVEDI 2164
            |.::  ||..:.:|    :|:: :.::...:..|.:||:              .|:::.|.||..
Zfish  2323 EQVE--EKQRQLEERGVAVEKALRGEAGLYKGSSVSPKQRKRRSDYWGESNYSEILDLHLGVEPY 2385

  Fly  2165 KNLPK------------TGCDK---------------SSNSSRRGSQSSLIMSRRHSEISLNEKL 2202
            ...|:            .|..|               ..|:..|.....:|.:|   |:.|.::.
Zfish  2386 VGTPRRRALYLCPCCAPEGMGKKDDPKLMQEWFKLVQEKNALVRYESELMIFAR---ELELEDRQ 2447

  Fly  2203 N------QDALAALNQIEKEREAEQVDELFQSMVEEMEQEPQPTAIVE-----PPEEDIDADSL 2255
            :      ::.:|..:.::.|.|..:..::...|:|.:||.....|::|     ..|||.|.:::
Zfish  2448 SRLQQELRERMAIDDHLKTEEELAEEKQILNEMLEVVEQRDSLVALLEEQRLREKEEDKDLEAV 2511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MicalNP_001247015.1 MDR <114..>160 CDD:302572 31/45 (69%)
CH 563..>629 CDD:294029 21/65 (32%)
LIM_Mical 1097..1153 CDD:188823 28/55 (51%)
Ehrlichia_rpt <2081..2479 CDD:118064 47/233 (20%)
DUF3585 4592..4705 CDD:288945
mical3aXP_021323435.1 FAD_binding_3 91..>239 CDD:332373 104/147 (71%)
CH 536..636 CDD:306753 33/100 (33%)
LIM_Mical 1086..1140 CDD:188823 28/55 (51%)
Herpes_BLLF1 <1488..1803 CDD:330317 57/334 (17%)
DUF4045 <1840..>1896 CDD:330572 9/55 (16%)
SMC_N <2220..>2506 CDD:330553 62/310 (20%)
DUF3585 2318..2508 CDD:314926 33/194 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 485 1.000 Domainoid score I383
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 837 1.000 Inparanoid score I430
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001313
OrthoInspector 1 1.000 - - otm24310
orthoMCL 1 0.900 - - OOG6_103078
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4434
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.860

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