DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mical and Mical3

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	XP_038963797.1	Gene:	Mical3 / 362427	RGDID:	1359504	Length:	2275	Species:	Rattus norvegicus

Alignment Length:	2590	Identity:	716/2590 - (27%)
Similarity:	1090/2590 - (42%)	Gaps:	673/2590 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 MPQQQQQLTAQQQQQQQLLMAEHAAAAEAAELFDLLCVATTMRQILALHRAMCEAVGLRPSPLND 89
            |.:::|:.|.|                 |..|||....|||.:..|...:.:|:.:.|:|.....
  Rat     1 MEERKQETTNQ-----------------AHVLFDRFVQATTCKGTLRAFQELCDHLELKPKDYRS 48

  Fly    90 FYPRLKAKVRSWKAQALWKKFDARAAHRVYGKGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVV 154
            ||.:||:|:..|||:|||.|.|.|.:|:.|.||.|||.|:.|:||||||||||||:..|||||||
  Rat    49 FYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVV 113

  Fly   155 VLEKRDRITRNNVLHLWPFVITDLRNLGAKKFYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIH 219
            |:||||..:||||||||||.|.|||.|||||||||||||:||||||||||.:||||||:||:|||
  Rat   114 VIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIH 178

  Fly   220 EGVSFDHAVEPSGDGG----GWRAAVTPADHPVSHYEFDVLIGADGKRNMLD-FRRKEFRGKLAI 279
            ..|.|...|:|..|..    ||||.|.|..||||.|||:|:||.||:||.|: ||||||||||||
  Rat   179 VNVEFQGLVQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAI 243

  Fly   280 AITANFINKKTEAEAKVEEISGVAFIFNQAFFKELYGKTGIDLENIVYYKDETHYFVMTAKKHSL 344
            ||||||||:.|.|||||||||||||||||.||:||...|||||||||||||:||||||||||.||
  Rat   244 AITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSL 308

  Fly   345 IDKGVIIEDMADPGELLAPANVDTQKLHDYAREAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTS 409
            :|||||:.|..|...||:..|||.:.|.:||||||:||||.|:|:|:||:||||:|||||||||.
  Rat   309 LDKGVILHDYTDTELLLSRENVDQEALLNYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTC 373

  Fly   410 MFAAEMSCRVIVRKGARLMQCLVGDSLLEPFWPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGV 474
            |:|:|.:..|..:.|.:|:..||||||||||||.|:|.|||||::||:|:.::.|| ...|.|.|
  Rat   374 MYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWS-LGTSPLEV 437

  Fly   475 LAQRESIYRLLNQTTPDTLQRDISAYTVDPATRYPNLNRESVNSWQVKHLVDTDDPSILEQTFMD 539
            ||:||||||||.||||:.:.::.|.|::||.|||||:|...:...||:||.|:.:..       |
  Rat   438 LAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNININFLRPSQVRHLYDSGESK-------D 495

  Fly   540 THALQTPHL----DTPGRRKRRSGDLLPQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCA 600
            .| |:..:|    .||   |....:.:.:.:.||.|...|...|..: .:.:.:..:::|..|||
  Rat   496 IH-LEMENLVNSRTTP---KLTRNESVARSSKLLGWCQRQTDGYSGV-NVTDLTMSWKSGLALCA 555

  Fly   601 LINRYRPDLIDYAATKDMSPVECNELSFAVLERELHIDRVMSAKQSLDLTELESRIWLNYLDQIC 665
            :|:||||||||:.:..:.:..:.|:|:|.:.|:||.|..:|:.|:...:.|.:....:.||.|..
  Rat   556 IIHRYRPDLIDFDSLDEQNVEQNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFY 620

  Fly   666 DLFRGEIPHIKHPKMDFSDLRQKYRINHTHAQPDFSKLLATKPKAKSPMQDAVDIPTTVQRRSVL 730
            ::|:..:     ...|..||..:.:          :.|:|:   .|||:.....:..|:.|:
  Rat   621 EMFKDSL-----SSSDTLDLNAEEK----------AVLIAS---TKSPISFLSKLGQTISRK--- 664

  Fly   731 EEERAKRQRRHEQLLNIGGGAAGAAAGVAGSGTG---TTTQGQNDTPRRSKKRRQVDKTANILLL 792
               |:.:.::.:.                ..|.|   .|:|.:.:.|.||.|..:....:.:...
  Rat   665 ---RSPKDKKEKD----------------SDGAGKRRKTSQSEEEEPPRSYKGERPTLVSTLTDR 710

  Fly   793 RTALCHEISNAISAFETINEEERQQRLQEIEENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLL 857
            |........|.:....|       |.|.:.|||...:.:..|:|   .||
  Rat   711 RMDAAIGNQNKVKFMAT-------QLLAKFEENAPAQSTGVRRQ---STQ--------------- 750

  Fly   858 REGGEAGVAEDGTPFEDYSIFLYRQQAPVFNDRVKDLERKLLFPDRERGDIPSALPRTADEQFSD 922
                |.||:..                            ....|::.|   |:.:|:....|..:
  Rat   751 ----ERGVSRP----------------------------SWCLPEQGR---PARIPQWKQRQEKE 780

  Fly   923 RIKNMEQRMTGRGGLGGDKKPKDLMRAIGKIDSNDWNVREIEKKIELSKKTEIHGPKGREKVPKW 987
            |.:...:::.   .|.....|.......|         :::.:.:....:.: ..|......|:.
  Rat   781 RSRTCPKKVI---TLSPPPTPPSCRARSG---------QQMYRNVHADSRGK-QNPHHERPEPEP 832

  Fly   988 SKEQFQARQHKMSKPQRQDSREAEKFKDIDQTIRNLDKQLKEGHNLDVGERGRNKVASIAGQFGK 1052
            |: :|...|.::|...|..:|.|....|   ::|....::..|....:.|:       ||.|..:
  Rat   833 SR-RFFVDQWELSLSLRSSNRPASPSSD---SLRQKYIKMYTGGVSSLAEQ-------IANQLQR 886

  Fly  1053 KDEANS--DEKNAGSSNATTNTNNTVIPKSSSKVALAFKKQ-----AASEKCRFCKQTVYLMEKT 1110
            |::..:  |:|..||                      .||:     ..|:.|.||::.||:||:.
  Rat   887 KEQPKTLLDKKELGS----------------------IKKEFPQNLGGSDTCYFCQKRVYVMERL 929

  Fly  1111 TVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFRLPPKPLPQRTNKARKSAAAQP 1175
            :.||...||:|.||.:|.|.|||..||:|.:|  |:|||..|:..            |.|..||.
  Rat   930 SAEGKFFHRSCFKCDYCATTLRLSAYAYDIED--GKFYCKPHYCY------------RLSGYAQR 980

  Fly  1176 ASPAVPPTAGSV--------PTA-------AATSEHMDTTPPRDQV-DLLETSR-----ANASAD 1219
            ..|||.|.:|..        |||       ||||. .:.:|...|| :.:..|:     |.||.:
  Rat   981 KRPAVAPLSGKEAKGPLQDGPTADTNGLASAATSS-AERSPGLHQVTEFMAWSKWTSGPACASMN 1044

  Fly  1220 AMSD----------DEANVIDEHEWSGRNF--LPESNNDSQSE--LSS-------SDESDTESDS 1263
            .:.:          .|...::.:..|.|..  |.|...::|:|  |||       .|.:.:.|:|
  Rat  1045 GLEEPSIAKRLRGTPERIELENYRRSVRQVEELEEVPEETQAEHNLSSVLDKGTEEDAASSSSES 1109

  Fly  1264 EMFEEADD--------SPFGA------------------QTLQLASDWIGKQYCEDSDDSDDFYD 1302
            ||.||.::        |..|.                  :.|:.:.::..::..|:.:..||..:
  Rat  1110 EMEEEEEEDEEDQLPTSDLGGVPWKEAVRIHALLKGRSEEELEASKNFEPEEEEEEEEYEDDEEE 1174

  Fly  1303 SSEDDGKDDTEGEEFKKAREL----------RRQEV--------RLQPL-----PANLPTDTETE 1344
            ..|::.:...|||.....|||          :.:|:        |||.:     |..:..|....
  Rat  1175 YDEEEEESSEEGEYCPWDRELLQGQWLQHLSKEEEMGTCEAGNKRLQQIITAADPLAIQADVHWT 1239

  Fly  1345 KLKLNVDNKENM--ADRSSLKSGNSFESAR---------SQPSTPL----------STPTRVEME 1388
            .:: ..:.:|.|  ...||........|.|         :....||          |.|...|.|
  Rat  1240 HIR-EREEEERMLPPSESSTSRVTGLPSVRCAAVQAWLETVSGAPLDEDDLEEDVDSEPAETEGE 1303

  Fly  1389 QLERNAP---------RKFSSEIEAISEKLYHMNNMVKMNKDLEVLAKENLVKSDILRKLTLKEK 1444
            ..|...|         :.:|.:|.:.:|..:.:.:..|:..|||:...||
  Rat  1304 AAEDGDPGDTGAELDDQHWSDDIPSDAETEHRLQSQTKVKADLELRVSEN--------------- 1353

  Fly  1445 WLAENAAIAAGQKVTPTPSATAPGLQPKSKFDEKFEKVVSPPQPVVEPKPKPVIDFNLDELKPRK 1509
                     ..:|.:.||           |.:|:....||.|.   :|..|..:.|:    ....
  Rat  1354 ---------EEEKPSDTP-----------KQEERGPSQVSSPS---QPPQKQAVLFS----PAHS 1391

  Fly  1510 PNFEERPKEQLPRPESLKKPPQQKPKGSSTNVSRSNSLKSNASNGSPKVKKAPISNNSKMQIEGI 1574
            |..||            .|||   |...:|.|      ||.|..   .:..||:....|.:.||
  Rat  1392 PGAEE------------AKPP---PASITTKV------KSPAEE---PLFPAPLLLREKPKAEG- 1431

  Fly  1575 LGTLRKIQSQNSSDQDEDMDVDEDVERKPNKELNSKLKEIQASSFAGTMDHIKSQLTMPTVSAQA 1639
                          .:|...|...:..:|     ..|.|.::.:...:....:|.|..||  ...
  Rat  1432 --------------PEEQKTVHSPIRSQP-----VALPEARSPTSPTSSLQPESLLAPPT--PPT 1475

  Fly  1640 PPSMDLSKYFPNQKQEKSSTSSTNKNQVTLKDVNLAKYFPSSPAPQRRTVETVADRLK-KSQTEA 1703
            |||..|......|....:|..|..|:.:..:.|......|.:|.|.:...:. .|||. ....|.
  Rat  1476 PPSTQLPICSQPQPSSDASIPSPTKSPIRFQPVPAKTSTPLTPLPVKSQGDP-KDRLSGPLAVEE 1539

  Fly  1704 ALAKTKLLEDQANNQAEKTKKEVEKEGESKKITKKVADSKAVPPKRQASLDTFSLREHQMDGALD 1768
            ||.::.|:|:.....||..:.......:..|.::....|.|:.|   .||.::|:.:...|..|.
  Rat  1540 ALKRSDLVEEFWMKSAEIRRSLGLTPVDRNKGSEPSLPSPALKP---ISLKSYSVDKSPQDEGLC 1601

  Fly  1769 LTKKKGPTK-----ASAGVKKP-----------------------------------------AK 1787
            |.|.....|     .|||.:.|                                         ::
  Rat  1602 LLKPPSVPKRLGLPKSAGDQPPLLTPKSPSDKELRSNQEERRDLSSSSGLGLHGSSSNMKTLGSQ 1666

  Fly  1788 SGSTTSVTKAT---------------ATSKGKTIKIVKK----IVPKGTKA---KKAAEAAQESA 1830
            |.:|:..|..|               ||.:.|..:..::    ::|..|.|   :...||||
  Rat  1667 SFNTSDSTMLTPPSSPPPPPPPNEEPATLRRKPRQTFERREASVIPPPTPASFMRPPREAAQ--- 1728

  Fly  1831 VVEAPPEKK------------PPKDEAERILDEILGDG----EYRSPSSEYQRLFQDEKSPSDLS 1879
                ||.::            |..|:.|...|:...|.    ::.:|.|.:.|   .||.|:
  Rat  1729 ----PPREEVRKSFVESVDEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWSR---SEKLPA--- 1783

  Fly  1880 DNIDRILEESG----LDVELGLPKRSSKKLV--KTKSLGEGDFDMKPSKERLTGVQNI------- 1931
                   :|:|    |:.|: .|::.:..||  :.|.|.|   :...::|:....|.:
  Rat  1784 -------KENGRLPPLEQEV-QPQKRALPLVSAEAKELAE---ERMRAREKSVKSQALRDAMAKQ 1837

  Fly  1932 LKRFESMSSVTSQNSDEQAAFKLRRMEST---------TSNLSSLTRSRESLVSVSDSMS-DLEK 1986
            |.|.::|..|:|::....:..|...:|:|         ...|.....|.|.|...|||.. |...
  Rat  1838 LSRMQAMEMVSSRSRPAPSPGKEPGLEATKHPSLRGSQEPTLKHEATSEEILSPPSDSGGPDGSV 1902

  Fly  1987 TMDYLRNEWRNEATNFLQKKRDKFYA-KKEEQEKESK-----------------ILAKPDPL-DN 2032
            |        .:|.::...|||...:: ::.::||:||                 :.|||..| .:
  Rat  1903 T--------SSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGGRPPEKPSLSLPEDVAAKPKSLWKS 1959

  Fly  2033 LPVQYRDSKLAKFFGLAASKSP---------ENRKSPI-------------------------KK 2063
            :...|:..|..|....:.|.:|         :.|.|||                         ::
  Rat  1960 VFSGYKKDKKKKSDEKSCSSTPSSGATVDSGQRRASPIVRAELHLRRQLSFSEDSDLSSDDILER 2024

  Fly  2064 KKSPSKTPKV-------------TKANNSLEELAKISNVRQTKKAQPKTLKPVEVKPLKPASPVP 2115
            ....||...:             :|.....||.......|:.:||..:..|..|:|.|..|..:.
  Rat  2025 SSQKSKRESIYVPHGLAFRRAYSSKPRTYTEEELSAKLTRRVQKAARRQAKQEELKRLHRAQIIQ 2089

  Fly  2116 DDFEILDLLEKATEAKELERSKTKSPAVESISQTPKEAIVEISLPVEDIKNLPK----------- 2169
            ...|.::..::..|.:.:...|......:...::....::::.|.||.....|:
  Rat  2090 RQLEQVEEKQRQLEERGVAVEKALRGEADYWGESYYSGLIDLHLGVEPSGGTPRRRPLSFCPCCV 2154

  Fly  2170 -TGCDK---------------SSNSSRRGSQSSLIMSRRHSEISLNEKLN------QDALAALNQ 2212
             .|..|               ..|:..|.....:|.:|   |:.|.::.:      ::.:|..:.
  Rat  2155 QEGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFAR---ELELEDRQSRLQQELRERMAVEDH 2216

  Fly  2213 IEKEREAEQVDELFQSMVEEMEQEPQPTAIVE-------PPEEDIDADSLCTTIS 2260
            ::.|.|..:..::...|:|.:||.....|::|       ..::|::|..||...|
  Rat  2217 LKTEEELSEEKKILNEMLEVVEQRDSLVALLEEQRLREKEEDKDLEAAMLCKGFS 2271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572	31/45 (69%)
		CH	563..>629	CDD:294029	20/65 (31%)
		LIM_Mical	1097..1153	CDD:188823	27/55 (49%)
		Ehrlichia_rpt	<2081..2479	CDD:118064	39/220 (18%)
		DUF3585	4592..4705	CDD:288945
Mical3	XP_038963797.1	FAD_binding_3	87..>274	CDD:396193	138/186 (74%)
		CH_MICAL3	515..625	CDD:409100	32/110 (29%)
		LIM_Mical	916..970	CDD:188823	27/55 (49%)
		Herpes_BLLF1	<1336..1729	CDD:282904	95/491 (19%)
		DUF3585	2088..2256	CDD:403377	24/170 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	478	1.000	Domainoid score	I401
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	770	1.000	Inparanoid score	I513
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001313
OrthoInspector	1	1.000	-	-		otm45518
orthoMCL	1	0.900	-	-		OOG6_103078
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4434
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860