DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mical and Mical2

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	NP_001180234.1	Gene:	Mical2 / 320878	MGIID:	2444947	Length:	1102	Species:	Mus musculus

Alignment Length:	1242	Identity:	451/1242 - (36%)
Similarity:	621/1242 - (50%)	Gaps:	242/1242 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EHAAAAEAAELFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKF 110
            |....|:|:::|:....|||.:..|.....:...:.|.|....:||.:||:||.:|||:|||.|.
Mouse     5 EDEKQAQASQVFENFVQATTCKGTLQAFNILTCLLDLDPLDHRNFYSQLKSKVNTWKAKALWHKL 69

  Fly   111 DARAAHRVYGKGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVI 175
            |.|.:|:.|.:|.||:.|:.|::|.||||||||||...|||||||:||||..:||||||||||.|
Mouse    70 DKRGSHKEYKRGKACSNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDTFSRNNVLHLWPFTI 134

  Fly   176 TDLRNLGAKKFYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGG----G 236
            .|||.||||||||||||||||||||||||.:|.||||:||||:|..|.|...:||..|..    |
Mouse   135 HDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEVHVNVEFVRVLEPPEDQENQKVG 199

  Fly   237 WRAAVTPADHPVSHYEFDVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAKVEEIS 300
            |||...||||.:|.:||||:|||||.||.|: ||||||||||||||||||||:.:.|||||||||
Mouse   200 WRAEFLPADHALSDFEFDVIIGADGHRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEIS 264

  Fly   301 GVAFIFNQAFFKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPAN 365
            ||||||||.||::|..:|||||||||||||.||||||||||.||:|||||:.|..|...||...|
Mouse   265 GVAFIFNQKFFQDLKEETGIDLENIVYYKDSTHYFVMTAKKQSLLDKGVILNDYIDTEMLLCSEN 329

  Fly   366 VDTQKLHDYAREAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQC 430
            |:...|..||||||:|:|.||:|:|:||:||.|:|||||||||||:|:|.:..:..|:..:|:..
Mouse   330 VNQDNLLSYAREAADFATNYQLPSLDFAINHNGQPDVAMFDFTSMYASENAALMRERQAHQLLVA 394

  Fly   431 LVGDSLLEPFWPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQR 495
            ||||||||||||.|:|||||||::.|.|:.:|.| :.....|.|||:|||:||||.||||:.:.:
Mouse   395 LVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSW-DQGTPPLEVLAERESLYRLLPQTTPENINK 458

  Fly   496 DISAYTVDPATRYPNLNRESVNSWQVKHLVDTDDPSILEQTFMDTHALQT-PHLDTPGRRKRRSG 559
            :...||:||||||||||...|...|||||..|.:        ||...|:. ..:.......||..
Mouse   459 NFEQYTLDPATRYPNLNLHCVRPHQVKHLYITKE--------MDRFPLERWGSVRRSVSLSRRES 515

  Fly   560 DLLPQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECN 624
            |:.|.  .||.|...|...||.: .:.:.:..:|:|..|||:|:.:||:||::.:..:...||.|
Mouse   516 DIRPN--KLLTWCQQQTKGYQHV-RVTDLTTSWRSGLALCAIIHSFRPELINFDSLNEDDAVENN 577

  Fly   625 ELSFAVLERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSDLRQKY 689
            :|:|.|.:||..|..|.:.|:.....|.:....:.||.:..:||||.      |.......|:.|
Mouse   578 QLAFDVAKREFGILPVTTGKEMASTQEPDKLSMVMYLSKFYELFRGT------PLRPMDSWRKNY 636

  Fly   690 RIN------HTHAQPDFSKLLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRH-----EQ 743
            ..|      .|..|.::..|  |.|:.::|   .||..|        ||....::||.     |:
Mouse   637 GENADFGLGKTFIQNNYLNL--TLPRKRTP---RVDTQT--------EENDMNKRRRQGFNHLEE 688

  Fly   744 LLNIGGGAAGAAAGVAGSGTGTTTQGQNDTPRRSKKRRQVDKTANILLLRTALCHEISNAISAFE 808
            |.:....:.|::...|               :.|..:.:|...||.||.:             ||
Mouse   689 LPSFSSRSLGSSQEYA---------------KESGSQNKVKHMANQLLAK-------------FE 725

  Fly   809 --TINEEERQQRLQEIE----------------------ENRQERMSKRRQQRYHQTQNFYKSLQ 849
              |.|....:|..:.:.                      |....|:....::::..|
Mouse   726 ENTRNPSVVKQDCRRVSGIGKPVLCSASRPPGTSCCPKLEESTPRLPPPLKRQFSST-------- 782

  Fly   850 LLQAGKLLREGGEAGVAEDGTPFEDYSIFLYRQQAPVFNDRVKDLERKLLFPDRERGDIP--SAL 912
             :..|::|||                     ..|.|...:......|.....|.:.|.:.  :.|
Mouse   783 -VATGQVLRE---------------------LNQVPASGECPSRPWRARAKSDLQLGGVENLATL 825

  Fly   913 PRTADEQFS-----DRIKNMEQRMTGRGGLGGDKKPKDLMRAIGKIDSNDWNVREIEKKIE---- 968
            |||.....:     .|::.:|:::              |.:....:.:.:::.:.|::|..
Mouse   826 PRTCQGALALSGVLRRLQQVEEKV--------------LQKRAQNLANREFHTKNIKEKAAHLAS 876

  Fly   969 ------------LSKKT-EIHGPKGREKVPKWSKEQFQARQHKMSKPQRQDSREAEKFKDIDQTI 1020
                        |||:. ..|.|.....:|       .......|.|...||
Mouse   877 MFGHGDLPQDKLLSKRVPHAHPPSPPSCLP-------SPHPAAASSPPAADS------------- 921

  Fly  1021 RNLDKQLKEGHNLDVGERGRNKVASIAGQFGK------------KDEANSDEKNAGSSNATTNTN 1073
                  :.....|.||     ||:|..|...:            |.:|.|.:..:
Mouse   922 ------VSPARKLTVG-----KVSSGIGAAAEVLVNLYLNDHRPKTQATSPDLES---------- 965

  Fly  1074 NTVIPKSSSKVALAFKKQAASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAF 1138
                |:.:..::|     ...:.|.|||:.||::|:.:.||...|:.|.:|..|...|||..|||
Mouse   966 ----PRKAFPLSL-----GGRDTCYFCKKRVYMIERLSAEGHFFHQECFRCSVCSATLRLAAYAF 1021

  Fly  1139 DRDDPQGRFYCTQHF---RLPPKPLPQRT--NKARKSAAA---QPASPAVPPTAGSVPTAAATSE 1195
            |.|  :|:|||..||   :...|...:|.  |:.|:....   |.|.....||..|...||.::.
Mouse  1022 DCD--EGKFYCKPHFVHCKTSSKQRKRRAELNQQREEEGTWQEQEAPRRDVPTESSCAVAAISTP 1084

  Fly  1196 HMDTTPP 1202
              :.:||
Mouse  1085 --EGSPP 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572	27/45 (60%)
		CH	563..>629	CDD:294029	21/65 (32%)
		LIM_Mical	1097..1153	CDD:188823	25/55 (45%)
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945
Mical2	NP_001180234.1	Monooxygenase domain. /evidence=ECO:0000250\|UniProtKB:Q8VDP3	2..494		295/497 (59%)
		UbiH	87..>224	CDD:357568	93/136 (68%)
		CH	522..623	CDD:366016	32/101 (32%)
		Nuclear localization signal. /evidence=ECO:0000250	660..681		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..712		13/75 (17%)
		LIM_Mical	980..1034	CDD:188823	25/55 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	478	1.000	Domainoid score	I421
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001313
OrthoInspector	1	1.000	-	-		otm43455
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4660
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.800