Protein Alignment Mical and spdi

DIOPT Version :10

• Sequence 1: NP_001247015.1
• Gene: Mical / 41225
• FlyBaseID: FBgn0053208
• Length: 4743
• Species: Drosophila melanogaster
• Sequence 2: NP_001036254.1
• Gene: spdi / 31004
• FlyBaseID: FBgn0025633
• Length: 1094
• Species: Drosophila melanogaster
• Alignment Length: 1129
• Identity: 220/1129 - (19%)
• Similarity: 408/1129 - (36%)
• Gaps: 284/1129 - (25%)

  Fly  1352 NKENMADRSSLKSGNSFESARSQPSTPLSTPTRVEMEQLERNAPRKFSSEIEAISEKLYHMNNMV 1416
            :..|.:.:....|.|: ...:||.||.|:|    ..||.::::       |.|.:.|.|......
  Fly    18 HSSNSSHKQQQNSSNN-NRQKSQSSTSLNT----AHEQQQQHS-------ITAATTKFYAHQETA 70

  Fly  1417 KMNKDLEVLAKENLVKSDILRKLTLKEKWLAENAAIAAGQKVTPTPSATAPGLQPKSKFDEKFEK 1481
            ...:.::|..:..|:.::..::...:::.|.:.           ..|.|.|  |.|||.  |.:|
  Fly    71 SYERGVDVGDEGALLLTNQQQEQRRQQQQLLQQ-----------PQSNTLP--QKKSKL--KGQK 120

  Fly  1482 VVSPPQPVVEPKPKPVIDFNLDELKPRKPNFEERPKEQLPRPESLKKPPQQKPKGSS--TNVSRS 1544
                     :||..||...:.:..:|..|        |.|...||...||....|||  :|::.:
  Fly   121 ---------QPKLLPVQQPHSNAPEPHDP--------QQPLMTSLAAVPQASATGSSSNSNINNN 168

  Fly  1545 NSLKSNASNGSPKVKKAPISNNSKMQIEGILGTLRKIQSQNSSDQDEDMDVDEDVERKPNKELNS 1609
            |:|.:....|:    .|..:.:...|:...........|.|.|:...|..|
  Fly   169 NALAALQDGGA----AAAAAADFYQQLAAAATATATATSANGSNTSADSPV-------------- 215

  Fly  1610 KLKEIQASSFAGTMDHIKSQLTMPTVSAQA-PPSMDLSKYFPNQKQEKSSTSSTNKNQVTLKDVN 1673
                   |||...    .:.:.:..|:|.: .......:...|::|::....:.||.|...|.:
  Fly   216 -------SSFPAA----AAAVAVAAVAASSYQQQQQQQQLLNNEQQQQQLLEANNKMQELHKQM- 268

  Fly  1674 LAKYFPSSPAPQRRTVETVADRLKKSQTEAALAKTKLLEDQANNQAEKTKKEV---EKEGESKK- 1734
              :.|.|    ::..:||....|...|:|.|..|..|::.|  :..||::.|:   :.|.||.:
  Fly   269 --ERFRS----EQMQLETRITELLPYQSEVAKLKGDLVKMQ--SLQEKSQMEIGNLKYENESLRN 325

  Fly  1735 -----ITKKVADSKAVPPKRQASLDTFSLREHQMDGALDLTKKKGPTKASAGVKKP----AKSGS 1790
                 :...::|::    |.|...|  |.|.|              :.|.|.:..|    |..|:
  Fly   326 RLRDVVNSPLSDAE----KHQIIQD--SQRLH--------------SSAPASIALPSTHDAHDGT 370

  Fly  1791 ---TTSVTKATATSKGKTIKIVKKIVPKGTKAKKAAEAAQES--AVVEAPPEKKPPKDEAERILD 1850
               |....|.:::|:.....:..||:..........|..|.:  .:.:...:....:.|.||:.:
  Fly   371 PCLTPDWDKQSSSSEISVACLQDKIIQMEETHYSTNEELQATLQELADLQTQLTDTQTENERLAE 435

  Fly  1851 E--ILGD---------GEYRSPSSEYQR-LFQDEKSPSDLSDNIDRILEESGLDVELGLPKRSSK 1903
            |  :|..         .|.|:..|..|. |.:|.|.|:......:|  |:..||:.....:....
  Fly   436 EKDVLFQSLCRQTEKLNESRTQISTLQELLLRDTKQPAPEVSASER--EQKLLDLIKTSQEEREA 498

  Fly  1904 KLVKTKSLGEGDFDMKPSKERLTGVQNILKRFESMSSVTSQ----NSD---------------EQ 1949
            .|:|.:.||....:||.::|  .|...:.::.|.::.:.||    |::               .|
  Fly   499 VLLKQEELGAELAEMKQARE--AGQLELQRQRERIALLDSQLDAANAERRQGEAQFSQAMEEISQ 561

  Fly  1950 AAFKLRRMESTTSNLSSLTRSRESLVSVSDSMSDLEKTMDYLRNEWRNEATNFLQKKRDKFYAKK 2014
            .|.::.|:.:...|..|.....|:.:|..|. :||.:.:|..|.|     .:.|:::    .|:.
  Fly   562 RAIEISRLSTLLENARSKIEELEADLSRGDK-TDLSEVLDVARKE-----KDALEER----VAEL 616

  Fly  2015 EEQ--EKESKILAKPDPLDNLPVQYRDSKLAKFFGLAASKSPENRKSPIKKKKSPSKTPKVTKAN 2077
            ::|  ..::::....|.|..|.   .:.|:.|.....|....|.|...:::.|.     |:....
  Fly   617 QDQCSRSQAELRRLRDQLSGLT---EECKVVKNNAKCAVSHLEYRLEQLQRDKD-----KIAGEW 673

  Fly  2078 NSLEE-LAKIS---NVRQTKKAQ--------PKTLKPVEVKPLKPASPVPDDFEILDLLEKATEA 2130
            .:||| :|::.   ...|..|||        .:.|..|::|..:....:..:.::     :..||
  Fly   674 QALEERVAELQVQCKCHQEDKAQLQSLLAETQRHLGDVQLKLGEAECRLDQETQL-----RRKEA 733

  Fly  2131 KELERSKT------------KSPAVESISQ------TPKEAIVEISLPVEDIKNLPKTGCDKSS- 2176
            :|.::.:.            |:.|:.:..|      |.||   :|.|..:.::.|.|....:|.
  Fly   734 EEWQQFQADLLMTVRVANDFKTEALSAREQLVLDNKTQKE---KIRLLEQQLEKLTKQQMQQSET 795

  Fly  2177 -NSSRRGSQSSLIMSRRHSEISLNEKLNQDALAAL-NQIEKER---EAEQVDELFQSMVEEMEQE 2236
             .|.....|..:.|:.|.|::|.:.:.::.::..| ..||..:   :|::.:..:.|........
  Fly   796 PQSVLSTVQREMEMATRRSKLSFSRQDSRLSVKTLIESIENNKAQGKADESESHYSSTSSLNSGT 860

  Fly  2237 PQ--PTAIVEPPEED---------IDADSLCTTISKSPSAQPVTVVKRGSSEDQSIEKLFSHFSD 2290
            |.  .|.|:.||..|         :.:.:|...:.....|...|....||..|
  Fly   861 PDLGTTPIIFPPSSDWHESIRLPVLQSTNLHVNVGNEVGAGQGTNTSSGSGGD------------ 913

  Fly  2291 EMLVNVEFDSNDELVGITPRATLVSRNTEDRDYLDKLESLERDEETFQPVVGEKFIQENVQDEVD 2355
                          :..|.:|||..|:.                        ::....:.|.:|.
  Fly   914 --------------LASTTKATLPLRDQ------------------------QQLAITSTQSQVQ 940

  Fly  2356 GLHFPSRPQRRPKSSSSSSEPSLP 2379
            .:..||.| ..|.|:.|||...||
  Fly   941 NVSQPSTP-ATPSSAGSSSSGGLP 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	UbiH	128..>263	CDD:440419
		CH_SF	567..669	CDD:469584
		LIM_Mical	1097..1153	CDD:188823
		PRK10819	<1450..>1557	CDD:236768	28/108 (26%)
		bMERB_dom	4592..4705	CDD:463467
spdi	NP_001036254.1	SMC_prok_B	<257..>845	CDD:274008	130/646 (20%)
		Smc	<501..>794	CDD:440809	61/320 (19%)
		CH_CYTS	982..1093	CDD:409048