DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mical and Mical1

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	XP_038954550.1	Gene:	Mical1 / 294520	RGDID:	1309386	Length:	1058	Species:	Rattus norvegicus

Alignment Length:	1480	Identity:	406/1480 - (27%)
Similarity:	579/1480 - (39%)	Gaps:	530/1480 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 MAEHAAAAEAAELFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWK 108
            ||...:...|.:.|:....|...:.:|:..:.:|.|:|:........|.::||::..|.|::||.
  Rat     1 MASPTSTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLPQYHKIKAQLNYWSAKSLWA 65

  Fly   109 KFDARAAHRVYGKGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPF 173
            |.|.||:...|.:|.|||.|:.||:||||||||.|:|..||||:||::|||.:.:|:||||||||
  Rat    66 KLDKRASQPAYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRTKFSRHNVLHLWPF 130

  Fly   174 VITDLRNLGAKKFYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGGGWR 238
            .|.|||.||||||||:||.|::|||||||||.:|||||||||||||.|.:|.....|...|.|||
  Rat   131 TIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGFTFTGLQPPPKKGSGWR 195

  Fly   239 AAVTPA-DHPVSHYEFDVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAKVEEISG 301
            |.:.|: ...::.|||||||.|.|.:.:.: |..:|.||||||.|||||:|.:|..|.:|.||||
  Rat   196 ARIQPSPPAQLASYEFDVLISAGGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISG 260

  Fly   302 VAFIFNQAFFKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPANV 366
            ||.|:||.||:.|...|||||||||||||:||||||||||..|:..||:.:|:.:..:||..|||
  Rat   261 VARIYNQKFFQSLLKATGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDLPETDQLLGKANV 325

  Fly   367 DTQKLHDYAREAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQCL 431
            ..:.|..:||.||:|:||.::..||||.:..|:||||.||||||..:|.|.|:..:.||||:..|
  Rat   326 VPEALQQFARAAADFATQGKLGKLEFAQDARGRPDVAAFDFTSMMRSESSARIQEKHGARLLLGL 390

  Fly   432 VGDSLLEPFWPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQRD 496
            |||.|:|||||.|:|.|||||::.|||:.:|.|:. ....|.:||:|||:|:||:||:|:.:.|:
  Rat   391 VGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAE-GTGPLELLAERESLYQLLSQTSPENMHRN 454

  Fly   497 ISAYTVDPATRYPNLNRESVNSWQVKHLVDTDDPSILEQTFMDTHALQTPHLDTPGRRKRRSGDL 561
            ::.|.:||||||||||..:|...||:.|.|..|..         ||.:..  |....||..:|..
  Rat   455 VAQYGLDPATRYPNLNLRAVTPNQVQDLYDIMDKE---------HARKKS--DETDARKTTTGSA 508

  Fly   562 LPQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECNEL 626
            ..:  .||.|...|...:..: .:.:.|..:.:||.||||::|.:|.|::.:..:.||.:|....
  Rat   509 GTE--ELLHWCQEQTAGFPGV-SVTDFSSSWADGRALCALVHRLQPGLLEPSELQGMSALEATAW 570

  Fly   627 SFAVLERELHIDRVMSAK------QSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSDL 685
            :..|.|.||.|..|:||:      ..|.|        :.||......|: ..||       .|.|
  Rat   571 ALRVAEYELGIIPVLSAQAVVAGSDPLGL--------IAYLSHFHSAFK-NTPH-------SSGL 619

  Fly   686 RQKYRINHTHAQPDFSKLLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLLNIGGG 750
                 ::..|..|.....|                              .|.||..::
  Rat   620 -----VSQPHGTPSAILFL------------------------------GKLQRSLQR------- 642

  Fly   751 AAGAAAGVAGSGTGTTTQGQNDTPRRSKKRRQVDKTANILLLRTALCHEISNAISAFETINEEER 815
                          |.|:.:.:||                      |.|
  Rat   643 --------------TRTKVEEETP----------------------CTE---------------- 655

  Fly   816 QQRLQEIEENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDYSIFLY 880
                                                          |..|:|.
  Rat   656 ----------------------------------------------EPPVSEP------------ 662

  Fly   881 RQQAPVFNDRVKDLERKLLFPDRERGDIPSALPRTADEQFSDRIKNMEQRMTGRGGLGGDKKPKD 945
                                      .:|.|||
  Rat   663 --------------------------SVPPALP-------------------------------- 669

  Fly   946 LMRAIGKIDSNDWNVREIEKKIELSKKTEIHGPKGREKVPKWSKEQFQARQHKMSKPQRQDSREA 1010

  Rat   670 ----------------------------------------------------------------- 669

  Fly  1011 EKFKDIDQTIRNLDKQLKEGHNLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTNNT 1075
                                                           |:.:.||
  Rat   670 -----------------------------------------------SEHEEAG----------- 676

  Fly  1076 VIPKSSSKVALAFKKQAASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDR 1140
                             |.:.|..|.:.:|::|:..|:|...||.|..|..|...||.|||....
  Rat   677 -----------------AEDVCELCGKRLYILERFCVDGHFFHRGCFCCRTCEATLRPGGYGQYP 724

  Fly  1141 DDPQGRFYCTQHFRLPPKPLPQRTNK----------------ARKSAAAQPASPAVPPTAGSVPT 1189
            .|  |.|||.||       |||...|                ...:..:.|:|| |||...:.|.
  Rat   725 GD--GYFYCLQH-------LPQEDQKEADNNGSPENQELPTPGDSTTQSGPSSP-VPPVTEASPV 779

  Fly  1190 AAATSEHMDTTPPRDQVDLLETSRANASADAMSDDEANVIDEHEWSGRNFLPESNND-------- 1246
            .:.:.      |.|..:.|....|...|:                  .|.:|:|..:
  Rat   780 PSPSQ------PARRLIRLSSVERLRLSS------------------LNIIPDSGVEPPPKPPRS 820

  Fly  1247 ----SQSELSSS--------------------DESDTESDSEMFEEADDSPFGAQTLQ---LASD 1284
                :|..|.||                    :|.:.|.:.|..||....|...:..|   |.:.
  Rat   821 CLDLAQESLKSSFMGWGVLRAPQVPEAIEKGEEEEEEEEEEEEEEEELPPPLALEVEQGPDLTAP 885

  Fly  1285 WIGKQYCEDSDDSDDFYD-----------SSEDDGKDDTEGEEFKKARELRRQEVRLQPLPANLP 1338
            .:.:.....:.:|.|...           :.|::.|      .|.||:.::|   ||..:.|.:
  Rat   886 TLPQSLLTLAKNSGDMTKYPTWRRTLMRRAKEEEMK------RFCKAQAIQR---RLNEIEAAM- 940

  Fly  1339 TDTETEKLKLNVDNKENMADRSSLKSGNSFESARSQPSTPLSTPTRVEMEQLERNAPRKFS---- 1399
            .:.|||.:||.|                   :.|.:.|:| ....::.:|||.:...:|.|
  Rat   941 RELETEGMKLEV-------------------ALRKESSSP-EKQKKLWLEQLLQLIQKKNSLVTE 985

  Fly  1400 ----------SEIEAISEKLYHMNNMVKMNKDLEVLAKENLVKSDILRKL 1439
                      .::|....:|.|....:...:.|:..| :.|.:..:||||
  Rat   986 EAELMITVQELDLEEKQRQLDHEFRGINREETLKTQA-DRLSEDRVLRKL 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572	27/45 (60%)
		CH	563..>629	CDD:294029	17/65 (26%)
		LIM_Mical	1097..1153	CDD:188823	22/55 (40%)
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945
Mical1	XP_038954550.1	FAD_binding_3	85..>122	CDD:396193	22/36 (61%)
		CH_MICAL1	506..611	CDD:409045	30/115 (26%)
		LIM	681..734	CDD:413332	21/54 (39%)
		DUF3585	929..1056	CDD:403377	28/131 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8209
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001313
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103078
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.670