DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mical and ltd-1

DIOPT Version :9

Sequence 1:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster
Sequence 2:	NP_495697.2	Gene:	ltd-1 / 174301	WormBaseID:	WBGene00003089	Length:	723	Species:	Caenorhabditis elegans

Alignment Length:	429	Identity:	87/429 - (20%)
Similarity:	139/429 - (32%)	Gaps:	137/429 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1093 ASEKCRFCKQTVYLMEKT--TVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGR-FYCTQHFR 1154
            :.:.|..|.:.||..:|.  ..:....|:.|.||:.|.|.|.|..|..:|:|...: .||:.|.
Worm     3 SKQHCNRCGKQVYPTDKVGPLKDSTFFHQGCFKCYICGTRLALKTYCNNRNDINDKEVYCSNHV- 66

  Fly  1155 LPPKPLPQRTNKARKSAAAQPASPAVPPTAGSVPTAAATSEHMDTTPPRDQVDLLETSRANASAD 1219
                                       |.||                |.|    |..:..|.
Worm    67 ---------------------------PIAG----------------PHD----LPMASTNG--- 81

  Fly  1220 AMSDDEANVIDEHEWSGRNFLPESNNDSQSELSSSDESDTESDSEMFEEADDSPFGAQTLQLASD 1284
                           ||:| |..:|:........:..||.:....|           :..|:|..
Worm    82 ---------------SGKN-LENNNHVKNGNWIDAGLSDMKIAHAM-----------KATQVARP 119

  Fly  1285 W-----IGKQYCEDSD-----------DSDDFYDS--------SEDDGKDDTEG-----EEFKKA 1320
            :     .|.:|..|.|           |.||.|:|        :|:..|::||.     .||.|.
Worm   120 YPKISHEGAKYVVDYDTQTRLELLHRKDEDDLYESFQDKRVREAEEFEKENTEEWEKALAEFAKK 184

  Fly  1321 RELRRQEVRLQPLPANLPTDTETEKLKLNVDNKE-------NMADRSSLKSGNSFESARSQ---- 1374
            .|..:..::...|...|....|.:...|:...||       .:.||.:.:....|:::||:
Worm   185 YEKGQSNMKKDDLIRQLTIKREKKLETLHTKRKERERHQTAELVDRQAKEMLELFKASRSEYSNL 249

  Fly  1375 --PSTPLSTPTRVEMEQLERNAPRKFSSEIEAISEKLYHMNNMVKMNKDLEVLAKENLVKSD--- 1434
              |||| ..|......:.|......:.|.|:.::  ::...|.|....|| :....:..:||
Worm   250 QYPSTP-PPPVPPSCSKREIYTTTDYFSSIDEVA--IHCARNEVASFTDL-IRTLSSGARSDVDV 310

  Fly  1435 ---ILRKLTLKEKWLAENAAIAAGQKVTPTPSATAPGLQ 1470
               |.|.:|:|..    |..|........||.....|::
Worm   311 ARAIYRWITIKNL----NTMIFDDSIQNDTPMGLLRGIK 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572
		CH	563..>629	CDD:294029
		LIM_Mical	1097..1153	CDD:188823	18/58 (31%)
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945
ltd-1	NP_495697.2	LIM_Ltd-1	7..66	CDD:188827	18/58 (31%)
ltd-1	NP_495697.2	CYK3	<295..>484	CDD:227604	13/56 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810