DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mical and Mical1

DIOPT Version :9

Sequence 1:NP_001247015.1 Gene:Mical / 41225 FlyBaseID:FBgn0053208 Length:4743 Species:Drosophila melanogaster
Sequence 2:XP_006512633.1 Gene:Mical1 / 171580 MGIID:2385847 Length:1207 Species:Mus musculus


Alignment Length:1516 Identity:419/1516 - (27%)
Similarity:599/1516 - (39%) Gaps:529/1516 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 QRHHQQHHHLPPHQQPQQQMPQQQQQLTAQQQQ---------QQQLLMAEHAAAAEAAELFDLLC 61
            |.|..|||  |......|.:|:...:.|..:..         ||...||..|:...|.:.|:...
Mouse   115 QNHALQHH--PAGVGGTQAVPRGGLRSTEVRNTGFSPSCSCCQQGPYMASPASTNPAHDHFETFV 177

  Fly    62 VATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKFDARAAHRVYGKGAACT 126
            .|...:.:|:..:.:|.|:|:........|.::||::..|.|::||.|.|.||:..||.:|.|||
Mouse   178 QAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACT 242

  Fly   127 GTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVITDLRNLGAKKFYGKFC 191
            .|:.||:||||||||.|:|..||||:||::|||.:.:|:||||||||.|.|||.||||||||:||
Mouse   243 NTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFC 307

  Fly   192 AGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGGGWRAAVTPADHP---VSHYEF 253
            .|::|||||||||.:|||||||||||||.||.|.....|...|.||||.:.|  :|   ::.|||
Mouse   308 TGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQP--NPPAQLASYEF 370

  Fly   254 DVLIGADGKRNMLD-FRRKEFRGKLAIAITANFINKKTEAEAKVEEISGVAFIFNQAFFKELYGK 317
            ||||.|.|.:.:.: |..:|.||||||.|||||:|.:|..|.:|.||||||.|:||.||:.|...
Mouse   371 DVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKA 435

  Fly   318 TGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPANVDTQKLHDYAREAAEFS 382
            ||||||||||||||||||||||||..|:..||:.:|:::..:||..|||..:.|..:||.||:|:
Mouse   436 TGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFA 500

  Fly   383 TQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQCLVGDSLLEPFWPTGSGC 447
            |..::..||||.:..|:||||.||||||..||.|.||..:.||||:..||||.|:|||||.|:|.
Mouse   501 THGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGV 565

  Fly   448 ARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQRDISAYTVDPATRYPNLN 512
            |||||::.|||:.:|.|:... ..|.|||:|||:|:||:||:|:.:.|:::.|.:||||||||||
Mouse   566 ARGFLAAFDAAWMVKRWAEGA-GPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLN 629

  Fly   513 RESVNSWQVKHLVDTDDPSILEQTFMDTHALQTPHLDTPGRRKRRSGDLLPQGATLLRWISAQLH 577
            ..:|...||:.|.|..|..         ||.:..  |.|..||..:|....:  .||.|...|..
Mouse   630 LRAVTPNQVQDLYDMMDKE---------HAQRKS--DEPDSRKTTTGSAGTE--ELLHWCQEQTA 681

  Fly   578 SYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECNELSFAVLERELHIDRVMS 642
            .:..: .:.:.|..:.:|..||||::..:|.|::.:..:.|..:|....:..|.|.||.|..|:|
Mouse   682 GFPGV-HVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELGITPVLS 745

  Fly   643 AKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSDLRQKYRINHTHAQPDFSKLLATK 707
            |:..:..:           |.:     |.|.::.|....|.        |.:|            
Mouse   746 AQAVMAGS-----------DPL-----GLIAYLSHFHSAFK--------NTSH------------ 774

  Fly   708 PKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLLNIGGGAAGAAAGVAGSGTGTTTQGQND 772
                                                           ::|:....:||.:.    
Mouse   775 -----------------------------------------------SSGLVSQPSGTPSA---- 788

  Fly   773 TPRRSKKRRQVDKTANILLLRTALCHEISNAISAFETINEEERQQRLQEIEENRQERMSKRRQQR 837
                            ||.|                                             
Mouse   789 ----------------ILFL--------------------------------------------- 792

  Fly   838 YHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDYSIFLYRQQAPVFNDRVKDLERKLLFPD 902
                            |||.|                                            
Mouse   793 ----------------GKLQR-------------------------------------------- 797

  Fly   903 RERGDIPSALPRTADEQFSDRIKNMEQRMTGRGGLGGDKKPKDLMRAIGKIDSNDWNVREIEKKI 967
                                                      .|.|...|:|             
Mouse   798 ------------------------------------------SLQRTRAKVD------------- 807

  Fly   968 ELSKKTEIHGPKGREKVPKWSKEQFQARQHKMS--KPQRQDSREAEKFKDIDQTIRNLDKQLKEG 1030
                          |:.|  |.|:....:..||  .|:..:.:||                    
Mouse   808 --------------EETP--STEEPPVSEPSMSPNTPELSEHQEA-------------------- 836

  Fly  1031 HNLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTNNTVIPKSSSKVALAFKKQAASE 1095
                                                                         .|.|
Mouse   837 -------------------------------------------------------------GAEE 840

  Fly  1096 KCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFRLPPKPL 1160
            .|..|.:.:|::|:..|:|...||:|..||.|...|..|||.....|  |.|||.||       |
Mouse   841 LCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGD--GHFYCLQH-------L 896

  Fly  1161 PQRTNKARKSAAA-------QPASPAVPPTAGSVPTAAATSEHMDTTPPRDQVDLLETSRANASA 1218
            ||...|...:..:       .|....:.|...|.|....:.....:.|.|..:.|....|...|:
Mouse   897 PQEDQKEADNNGSLESQELPTPGDSNMQPDPSSPPVTRVSPVPSPSQPARRLIRLSSLERLRLSS 961

  Fly  1219 DAMSDDEANVIDEHEWSGRNFLPESNND-SQSELSSS-----------------DESDTESDSEM 1265
                   .|:|.:.........|.|.:| ::..|.||                 ::.|.|.:.|.
Mouse   962 -------LNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDEEEEEE 1019

  Fly  1266 FEEADDSPF------------------GAQT---------LQLASDWIGKQYCEDSDDSDDFYDS 1303
            .||.::.|.                  ||.|         ::.|.:...|::|            
Mouse  1020 EEEEEEEPLPPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFC------------ 1072

  Fly  1304 SEDDGKDDTEGEEFKKARELRRQEVRLQPLPANLPTDTETEKLKLNVDNKENMADRSSLKSGNSF 1368
                           ||:.::|   ||..:.|.: .:.|.|..||.:                  
Mouse  1073 ---------------KAQAIQR---RLNEIEATM-RELEAEGTKLEL------------------ 1100

  Fly  1369 ESARSQPSTPLSTPTRVEMEQLERNAPRKFSSEIEA-----------ISEKLYHMNNMVK--MNK 1420
             :.|.:.|:| ....::.::||.|...:|.|...|.           :.||...:::.::  ||:
Mouse  1101 -ALRKESSSP-EQQKKLWLDQLLRLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHELRGYMNR 1163

  Fly  1421 DLEVLAKENLVKSD--ILRKL 1439
            : |.:..|..::|:  :||||
Mouse  1164 E-ETMKTEADLQSENQVLRKL 1183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MicalNP_001247015.1 MDR <114..>160 CDD:302572 28/45 (62%)
CH 563..>629 CDD:294029 14/65 (22%)
LIM_Mical 1097..1153 CDD:188823 22/55 (40%)
Ehrlichia_rpt <2081..2479 CDD:118064
DUF3585 4592..4705 CDD:288945
Mical1XP_006512633.1 FAD_binding_3 244..>281 CDD:366675 22/36 (61%)
CH 670..770 CDD:366016 26/118 (22%)
LIM_Mical_like 842..895 CDD:188744 21/54 (39%)
DUF3585 1077..1205 CDD:371910 28/132 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 83 1.000 Domainoid score I8334
eggNOG 1 0.900 - - E2759_KOG1700
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001313
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103078
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.670

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