Protein Alignment Mical and CSRP1

DIOPT Version :10

• Sequence 1: NP_001247015.1
• Gene: Mical / 41225
• FlyBaseID: FBgn0053208
• Length: 4743
• Species: Drosophila melanogaster
• Sequence 2: NP_004069.1
• Gene: CSRP1 / 1465
• HGNCID: 2469
• Length: 193
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 108/611 - (17%)
• Similarity: 206/611 - (33%)
• Gaps: 203/611 - (33%)

  Fly   130 KTRARSTSKKNQPRSQFDAQPENVNISEESEGR-DSEKEKNDRQL----EKLRNRNDELKIRVKE 189
            :||.|:..::.:....|..|....:|:|..:.| :::|.||  |:    .||::...||.|.::|
Human    53 ETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKN--QVTDTNRKLQHEGKELVIAMEE 115

  Fly   190 YKS------DLSAA-------------------QLKVKNLEKKLESAQSAD-------SEEKF-- 220
            .|.      ::||.                   |:|.|.....|::.:..:       |..:|
Human   116 LKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCK 180

  Fly   221 VRIDSEIDEKRSQDHDEEINNLHNVIEELR---NKLATVESKNKDLETKFSENQDYL-------- 274
            |.:|: |.:.|.:..|..:::|.:.:|.:|   :|:.....|    :.:...|.|.:
Human   181 VMVDN-IPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMK----QAQQQRNLDNIVLQQPRIG 240

  Fly   275 ---KNAKDKVTFLENQLNS-----------------DAHEEVK--------STAVRALEVKLGLA 311
               |:.||..|..:.::.|                 :..|||.        |...|.|.:...|.
Human   241 SKRKSKKDVYTIFDAEVESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLG 305

  Fly   312 NNSIRQAEAEKQQLQEANW-----------------YANERVGKLEQENGYLKGITEQLKARADT 359
            .....:....||:.::|..                 |.|:.||....|: ::...|:.|..||..
Human   306 ARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVED-HILHTTQGLVNRAYI 369

  Fly   360 SHAEKMLKDSEKRVWEINEEKSKLEWRLGELSQWWNDAKWKVGELESSVALQRNLLDTANSKIQS 424
            .           .:||:  ..||....|...|.:.:|.. .|.:|::.:.|..:.|......:..
Human   370 D-----------ELWEM--ALSKTIAALRTHSSYCSDPN-LVLDLKNLIVLFADTLQVYGFPVNQ 420

  Fly   425 LNDQLIQEVRSHSSTM----------TIPTDGFT-ISQSNQGTWNLANGSNQPCFTGAIPSIPLV 478
            |.|.|::....:|.|:          .:.:|.:: |..:::.|:....|  |..|.......|..
Human   421 LFDMLLEIRDQYSETLLKKWAGVFRNILDSDNYSPIPVTSEETYKKVVG--QFPFQDIELEKPFP 483

  Fly   479 SALPFAGANPFIFGGANE-------------------------GRN--VTLTISNTEQ------- 509
            ...||:...|.::....|                         ..|  :|.|:||:.|
Human   484 KKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKN 548

  Fly   510 -------EVYLTGSFINWKC----------------TLKCEKLV----------SGKKGVTVNLT 541
                   ::.:..:.:...|                |:...||.          :.::.:..||.
Human   549 IGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLN 613

  Fly   542 RGRHEFRFMINGEWAT------SSDY 561
            :...:|..:.:.:|.|      :|||
Human   614 QKIDQFLQLADYDWMTGDLDNKASDY 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mical	NP_001247015.1	UbiH	128..>263	CDD:440419	37/174 (21%)
		CH_SF	567..669	CDD:469584
		LIM_Mical	1097..1153	CDD:188823
		PRK10819	<1450..>1557	CDD:236768
		bMERB_dom	4592..4705	CDD:463467
CSRP1	NP_004069.1	LIM1_CRP1	8..63	CDD:188863	3/9 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	64..69		0/4 (0%)
		LIM2_CRP	119..172	CDD:188787	6/52 (12%)