DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mical and Micalcl

DIOPT Version :9

Sequence 1:NP_001247015.1 Gene:Mical / 41225 FlyBaseID:FBgn0053208 Length:4743 Species:Drosophila melanogaster
Sequence 2:NP_001368791.1 Gene:Micalcl / 100504195 MGIID:1918127 Length:680 Species:Mus musculus


Alignment Length:852 Identity:184/852 - (21%)
Similarity:290/852 - (34%) Gaps:304/852 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  3949 PSSSEQQPKTSTVTSSSTGPNSSTTGNV-------SKEPQEEDLQIQFEYVRALQQRISQIST-- 4004
            ||..::.|...:::|||:.|:|.::.:|       |..||          |.|......|||.  
Mouse     6 PSPPKEPPPPPSLSSSSSLPSSFSSASVPGHTADDSSSPQ----------VPAYNLHSPQISRGD 60

  Fly  4005 -------QRRKSSKGEAPNLQLN-SSAPVIESAED-PAKPAEEPLVSMRPRTTS----------- 4049
                   .||..::|....:.|. ..:|::||.|| ..:|..|.|.|....::|           
Mouse    61 VSPTPIYLRRARAQGIVKEIPLYLPHSPMLESTEDCLVEPGRESLRSPEEISSSEGCQEARALGN 125

  Fly  4050 -------ISGKVPEIPTLSSKL--------------------EEITKERTKQKDLIHDLVMDKLQ 4087
                   |.||...:|..:..|                    .|::|||   |..:..||:.:.|
Mouse   126 TRSIQHPILGKDQYLPNQNLALGAAGNPGDPREESRMGQPGGPELSKER---KLGLKKLVLTEEQ 187

  Fly  4088 SKKQLNAE--KRLHRS-RQRSLLTSGYASGSSLSPTPKLAAACSPQDSNCSSQAHYHASTAEEAP 4149
            ..|.|:..  .:.|:: .|.|..::....|.||.||             ||       ||..:|.
Mouse   188 KNKLLDWSDCTQEHKTGEQLSQESAENIRGGSLKPT-------------CS-------STLSQAV 232

  Fly  4150 KPPAERPL-QKSATSTYVSPYRTVQAPTRSADLYKPRPFSEHIDSNALAGYKLGKTASFNGGKLG 4213
            |   |:.| ||.|.....:|  .|:||...                                   
Mouse   233 K---EKLLSQKKALGGMRTP--AVKAPQER----------------------------------- 257

  Fly  4214 DFAKPIAPARVNRGGGVATADIANISASTENLRSEARARARLKSNTELGLSPEEKMQLIRSRLHY 4278
            :...|.:|.::          |||                                .::||.||.
Mouse   258 EVPPPKSPLKL----------IAN--------------------------------AILRSLLHN 280

  Fly  4279 DQ-NRSLKPK-QLEEMPSGDLAARA---RKMSASKSVNDLAYMVGQQQQ--QQVEKDAVLQAKAA 4336
            .: .:...|| :.:.:|.|...||:   ||:.:||.        |.||.  :.:.|      ||:
Mouse   281 SEAGKKTSPKPESKTLPRGQPHARSFSLRKLGSSKD--------GDQQSPGRHMAK------KAS 331

  Fly  4337 DFTSDPNLASGGQEKAGKTKSGRRPKDPERRKSLIQSLSSFFQKGSGSAASSSKEQGGAVAAVHS 4401
            .|.|   ||| ...|..:......|....|.:||....|..|                       
Mouse   332 AFFS---LAS-PTSKVAQASDLSLPNSILRSRSLPSRPSKMF----------------------- 369

  Fly  4402 EQSERPGTSSSGTPT------ISDAAGGGGGGGGVFSRFRISPKSKEK-SKSCFDLRNFGF---- 4455
             .|..|.:.....||      :.||......|....|...:..||.|. .:.|...::.|.    
Mouse   370 -FSTTPHSKVEDVPTLLEKVSLQDATHSPKTGASHISSLGLKDKSFESFLQECKQRKDIGDFFNS 433

  Fly  4456 -------GDKDMLVCNAASPAGATSASQKNHSQEYLNTTNNSRYRKQTNTAKPKPESFSSSSPQL 4513
                   |::...:.....|.|:||..|                                     
Mouse   434 PKEEGPPGNRVPSLEKLVQPVGSTSMGQ------------------------------------- 461

  Fly  4514 YIHKPHHLAAAHPSALDDQTPPPIP-------PLPLNYQRSDDESYANETREH--KKQRAISKAS 4569
                     .||||:......|..|       |...:.:...|...:...:|.  :::|.:.|.|
Mouse   462 ---------VAHPSSTGQDAHPVAPVTEATSSPTSSSAEEEADSQLSLRIKEKILRRRRKLEKQS 517

  Fly  4570 -RQAELKRLRIAQEIQREQEEIEVQLKDLEARGVLIEKALRGEAQNIENLDATKDNDEKLLKELL 4633
             :|.|||||..||.|||:.||:|.:.:.|..:||.:||.|||||      |:...::.:||:|..
Mouse   518 AKQEELKRLHKAQAIQRQLEEVEERQRTLAIQGVKLEKVLRGEA------DSGTQDEAQLLQEWF 576

  Fly  4634 EIWRNITALKKRDEELTIRQQELQLEYRHAQLKEELNLRLSCNKLDKSSADVAAEGAILNEMLEI 4698
            ::......|.:.:.||.|..|||:||...::|:::|..::..::..|...|:..|..|..||:::
Mouse   577 KLVLEKNKLMRYESELLIMAQELELEDHQSRLEQKLRQKMLKDEGQKDENDLKEEQEIFEEMMQV 641

  Fly  4699 VAKRAAL 4705
            :.:|..|
Mouse   642 IEQRNKL 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MicalNP_001247015.1 MDR <114..>160 CDD:302572
CH 563..>629 CDD:294029
LIM_Mical 1097..1153 CDD:188823
Ehrlichia_rpt <2081..2479 CDD:118064
DUF3585 4592..4705 CDD:288945 32/112 (29%)
MicalclNP_001368791.1 Interaction with MAPK1 64..103 10/38 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..118 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..177 7/39 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..225 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..330 30/183 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..374 7/53 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..447 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 456..497 11/86 (13%)
DUF3585 532..660 CDD:403377 39/123 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63 17/66 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 83 1.000 Domainoid score I8334
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103078
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.900

Return to query results.
Submit another query.