DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mical and mical3

DIOPT Version :9

Sequence 1:NP_001247015.1 Gene:Mical / 41225 FlyBaseID:FBgn0053208 Length:4743 Species:Drosophila melanogaster
Sequence 2:XP_031754432.1 Gene:mical3 / 100486205 XenbaseID:XB-GENE-996271 Length:2242 Species:Xenopus tropicalis


Alignment Length:2630 Identity:739/2630 - (28%)
Similarity:1108/2630 - (42%) Gaps:620/2630 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 LFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKFDARAAHRVYG 120
            |||....|||.:..|...:.:|:.:.|:|.....||.:||:|:..|||:|||.|.|.|.||:.|.
 Frog    15 LFDRFVQATTCKGTLKSFQELCDHLDLKPKDYRTFYHKLKSKLNYWKAKALWSKLDKRGAHKDYK 79

  Fly   121 KGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVITDLRNLGAKK 185
            ||.||..|:.|:|||||||||||||...|||||||:||||..:||||||||||.|.|||.|||||
 Frog    80 KGKACINTKCLIIGAGPCGLRTAIELCFLGAKVVVVEKRDAFSRNNVLHLWPFTIHDLRGLGAKK 144

  Fly   186 FYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGD----GGGWRAAVTPADH 246
            ||||||||:||||||||||.:||||.|:||:|||..|.|...:||..|    ..||||.|.|..|
 Frog   145 FYGKFCAGAIDHISIRQLQLILLKVCLILGIEIHVNVEFQGLIEPPEDQENQRSGWRAKVYPKGH 209

  Fly   247 PVSHYEFDVLIGADGKRNML-DFRRKEFRGKLAIAITANFINKKTEAEAKVEEISGVAFIFNQAF 310
            .||.|||||:|||||:||.| .||||||||||||||||||||:.|.|||||||||||||||||.|
 Frog   210 CVSDYEFDVIIGADGRRNTLAGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKF 274

  Fly   311 FKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPANVDTQKLHDYA 375
            |::|...|||||||||||||:||||||||||.||::||||::|.||...||:.||||.:.|.:||
 Frog   275 FQDLREATGIDLENIVYYKDDTHYFVMTAKKQSLLEKGVILQDYADTELLLSRANVDQEALLNYA 339

  Fly   376 REAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQCLVGDSLLEPF 440
            .|||.|||..|:|.|:||:||||:|||||||||.|:|:|.:..|..|...||:..||||||||||
 Frog   340 TEAARFSTNQQLPALDFAINHYGQPDVAMFDFTCMYASENAALVRERNNQRLLVALVGDSLLEPF 404

  Fly   441 WPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQRDISAYTVDPA 505
            ||.|:|.|||||::||:|:.::.||... |.:.|||:||||||||.||||:.:.::.|.|:|||.
 Frog   405 WPMGTGIARGFLAAMDSAWMVRSWSQGA-SPMEVLAERESIYRLLPQTTPENVSKNFSQYSVDPT 468

  Fly   506 TRYPNLNRESVNSWQVKHLVDTD---DPSILEQTFMDTHALQTPHLDTPGRRK--RRSGDLLPQG 565
            |||||:|.:.:...||:||.:|.   ||:|.....:::   :||.|   ||.:  .|:|      
 Frog   469 TRYPNVNLQFLRPSQVRHLYNTSELKDPNIEIGNAVNS---RTPVL---GRNESVARTG------ 521

  Fly   566 ATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECNELSFAV 630
             .||.|...|:..|..: .:.:.:..:::|..|||:|:||||:||::.:..:....:.|:|:|.:
 Frog   522 -KLLGWCQKQMEGYPGV-NVTDLTMSWKSGLALCAIIHRYRPELINFESLDEQDVEKNNQLAFDI 584

  Fly   631 LERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSDLRQKYRINHTH 695
            .||||.|..:|:.|:...:.|.:....:.||.|..::|:         :.|..|..|       :
 Frog   585 AERELGISPIMTGKEMASVGEPDKLSMVVYLSQFYEMFK---------ESDAEDANQ-------Y 633

  Fly   696 AQPDFSKLLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLLNIGGGAAGAAAGVAG 760
            |....:.|.:|    |||:.....:..|:.|:...::::.|                  .:..:|
 Frog   634 ADEKAALLAST----KSPISFLSKLGQTISRKRTPKDKKEK------------------DSDASG 676

  Fly   761 SGTGTTTQGQNDTPRRSKKRRQVDKTANILLLRTALCHEISNAISAFETINEEERQQRLQEIEEN 825
            ....|:.....:.||..:                                  ||:...:..:.|.
 Frog   677 KRRKTSQSEDEEAPRTQR----------------------------------EEKPASVSAVAER 707

  Fly   826 RQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDYSIFLYRQQAPVFNDR 890
            |.|..|.       ..||..||:    |.:||.:                    :.:.||..|..
 Frog   708 RNETASA-------AGQNKVKSM----ATQLLAK--------------------FEENAPAPNAG 741

  Fly   891 VKDLERKLLFPDRERGDIPSALPRTADEQFSDRIKNMEQRMTGRG----GLGGDKKPKDLMRAIG 951
            ::.....|.:.:|.:.   .|..|..:.|:..|..|...|...:.    ..|....|..:::...
 Frog   742 LRKQRPTLPYQERLQN---QASQRQTEPQWKQRRDNQRPRSCPKKVITLNAGSSPVPLPVLQTTP 803

  Fly   952 KIDSNDWNVREIEKKIELSKKTEIHGPKGREKVPKWSKEQFQARQHKMSKPQRQDSREAEKFKDI 1016
            .:.|:.|   |....:|.| :|:...|.|     :|.:...|....:.|.|. .|:...:..|..
 Frog   804 VLGSSRW---EQCPTLERS-ETQSRSPAG-----QWQQTLAQRSSDRPSSPS-SDALRQKYIKMY 858

  Fly  1017 DQTIRNLDKQLKEGHNLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTNNTVIPKSS 1081
            ...:.:|.:|                   ||.|..||:                    |..|...
 Frog   859 TGGVSSLAEQ-------------------IANQLQKKE--------------------TPKPLFG 884

  Fly  1082 SKVALAFKKQ-----AASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRD 1141
            .||. :|:|:     ..|:.|.||::.||:||:.:.||...||:|.||.:|.|.|||..||:|.:
 Frog   885 KKVG-SFRKEFPQNLGGSDVCYFCRRRVYVMERLSAEGKFFHRSCFKCDYCSTTLRLSCYAYDLE 948

  Fly  1142 DPQGRFYCTQHF----------RLPPKP-------------LPQRTNKARKSAAAQPASPAVP-P 1182
            |  |:|||..|:          :.|..|             .|...::.|......||:...| |
 Frog   949 D--GKFYCKPHYCYRRSGYSQRKRPAMPALSGKEVTRTVEDTPDAEDQGRAPLLPAPAAEKTPGP 1011

  Fly  1183 TAGSVPTAAATSEHMDTTPPRDQVDLLETSRANASADAMSDDEANVIDEHEWSGRNFLPESNNDS 1247
            :...|...:| ::.:..||.|.:   ||..|.:...:.:.:.....:.||..|  :.|.:...:.
 Frog  1012 SVNGVEDHSA-AKRLRATPERIE---LENYRVSLQKEELEEVPEETLAEHNLS--SLLDKGEVEE 1070

  Fly  1248 QSELSSSDESDTESDSEMFEEADDSPFGAQTL------------------QLASDWIGKQYC--- 1291
            .:..||..|.:.|.|.|..||..........|                  .:..:.:|.|..   
 Frog  1071 VASSSSESEMEEEEDEEEEEEEPGECLPPSDLGGVPWKEAVKIHAKLKGQDIDVEVVGTQGAGGS 1135

  Fly  1292 -EDSDDSDDFYDSSEDDGKDDTEGEEFKKARELR----------------------RQEVRLQPL 1333
             |:.::.::..:..||:.....|||.....|||:                      |.:..|.|:
 Frog  1136 EEEEEEEEEEDEEEEDEEVSSEEGEYCPWERELQQGLWIQRISDEDTVGIFKAGNLRLQQALSPV 1200

  Fly  1334 -PANLPTDTE-TEKLKLNVDNKENMADR-----SSLKSGNSFESARSQP------STPLSTPTRV 1385
             |..:..|.. |...::..:.:.:..:|     ||........|.|..|      |...:|....
 Frog  1201 DPTEIKADVRWTHVREVKEERRGSKEERGEVSMSSPSKARHLHSHRHDPVRAWLESVSGATGEYE 1265

  Fly  1386 EME---------QLERNAPRKFSSEI--------EAISEKLYHMNNMVKMNKDLEVLAKENLVKS 1433
            |.|         |.|.......|:::        :|.:|:....:...|:..|   :|:|..|:.
 Frog  1266 EGEEEELGTCLAQAEAAGDGDTSADLGDDDDIPSDAEAEERLQQSQRFKLKLD---VAQEPKVEQ 1327

  Fly  1434 DILRKLTLKEKWLAENAAIAAGQKVTPTP---SATAPGLQPKSKFDEKFEKVVSPPQPVVEPK-- 1493
            .:|             .|||..:.| |:|   :..||.|.|:.....:.|||     ||:.||  
 Frog  1328 PVL-------------PAIADSESV-PSPVSLAPKAPVLSPRRTLKAEAEKV-----PVMSPKAV 1373

  Fly  1494 PKPVIDFNLDELKPRKPNFEERPKEQLPRPESLKKPPQQKPKGSSTNVSRSNSLKSNA--SNGSP 1556
            ..|...|..|...|...:.:...:.:.|.|.|   |...:|..|...|..::.:||.:  :|..|
 Frog  1374 TSPGGRFFADPYLPLDSSNKALVEAKTPTPLS---PVCSQPVPSQEPVIPTSPVKSPSVPANTRP 1435

  Fly  1557 KVK-KAPISNNSKMQIEGILGTLRKIQSQNSSDQDEDMDVDEDVERKPNKELNSKLKEIQASSFA 1620
            .:. .|||.:......||.|         |::|:       ..|.::|:                
 Frog  1436 LISPSAPICSQPLPSSEGTL---------NATDR-------PPVRQQPS---------------- 1468

  Fly  1621 GTMDHIKSQLTMPTVSAQAPPSMDLSKY-FPNQKQEKSSTSSTNKNQVTLKDVNLAKYFPSSPAP 1684
                        |.:     ||..|:|. |...........|.|..:| ||.::|.:.|.:..|.
 Frog  1469 ------------PLI-----PSTSLTKLPFTGHVMGSEQLVSPNAKEV-LKRIDLIEEFWTKSAE 1515

  Fly  1685 QRRTVETV-ADRLKKSQTE-AALAKTKLLEDQANNQAEKTKKEVEKEGESKKITKKVADSKAVPP 1747
            .||::... .||.:..:.. .|||.|.|     ..||.|:|.|.:|....|  .::||  :.|.|
 Frog  1516 IRRSLGLAPVDRDRVHEISFPALASTPL-----QPQAPKSKPEEQKSPSLK--PQQVA--RRVNP 1571

  Fly  1748 KRQASLDTFSLREHQMDGALDLTKKKGPTKASAGVKKPAKSGS-----TTSVTKATATSKGKTIK 1807
            .|   ||.     ..:.....::..:...|:|.|.||...:.|     .:|:|:..|:....|..
 Frog  1572 SR---LDI-----ELLSPLTPISPSEKELKSSDGEKKDISTSSGLGLNGSSITRTAASESFNTSD 1628

  Fly  1808 IVKKIVPKG------------------TKAKKAAEAAQESAVVEA-PPE-KKPPK-DEAER---- 1847
            ......|..                  |..:...|:....|:.:: ||| ||.|: :|:.|    
 Frog  1629 SAMLTPPSSPPPPPPQGEEPATLRRSRTPCQNGPESIPAPALAQSKPPEPKKSPRWEESVRKSFV 1693

  Fly  1848 -ILDEILGDGEYRSPSSEYQRLFQDEKSPSDLSDNIDRILEESGLDVELGLPKRSSKKLVKTKSL 1911
             .:|||        |       |.|     |:.|..|...|.|.|......|..|.   ||...:
 Frog  1694 ESVDEI--------P-------FAD-----DVEDTYDERTENSSLQERFFTPPTSR---VKPHRI 1735

  Fly  1912 G--EGDFDMKPSKERLTGVQNIL----------------KRFESMSSVTSQNSDEQAAFKLRRME 1958
            |  :.:.::..|.||:...:.:|                .|.:|:.|...:::..|...|::::|
 Frog  1736 GFSKENGEIPSSSERVHHRKRLLPDVTQEAKERAEERMKAREKSVKSQALKDAIAQQRHKMKQLE 1800

  Fly  1959 STTSNLSSLTRSRESLVSVSD--SMSDLEKTMDYLRNEWRNEATNFLQKKRDKFYAKKEEQEKES 2021
            ....:..:|    .|.|..||  ::|.|.:|.           |.....|.|      .:||...
 Frog  1801 PGARSAKAL----PSTVMFSDYPAVSPLLRTQ-----------TETPTLKLD------TDQEVFI 1844

  Fly  2022 KILAKPDPLDNLPVQYRDSKLAKFFGLAASKSPENRKSPIKKKKSPSKTPKVTKANNSLEELAKI 2086
            ...|.||                  |...|    :..|..|.||.||......|...|..|.::.
 Frog  1845 TPPAAPD------------------GSVTS----SEGSGGKPKKRPSIFSPRKKEKKSKGESSRA 1887

  Fly  2087 SNVRQT-KKAQPKTLKPVEVKPLKPASPVPDDFEILDLLEKATEAKELERSKTKSPAVESISQTP 2150
            |:.:.| :..:||:|..                .:....:|..:.|:.:.....:|:..|.|.|.
 Frog  1888 SDKQATDESTKPKSLWK----------------SVFSGYKKEKKKKQQQAEDKSTPSTPSSSTTV 1936

  Fly  2151 KEAIVEISLPVEDIKNLPKTGCDKSSNSSRRGSQSSLIMSRRHSEISLNEKLNQDALAALNQIEK 2215
            .....:::..:                   ||:..||   |||...|.:..|:.           
 Frog  1937 DSGKAKVANMI-------------------RGADLSL---RRHLSFSEDSDLSS----------- 1968

  Fly  2216 EREAEQVDELFQSMVEEMEQEPQPTAIVEPPEEDIDADSLCTTISKSPSAQPVTVVKRGSSEDQS 2280
                   |::.:...::.::|..|.|....||..:..|       :|.........:|..|..::
 Frog  1969 -------DDVLEKSSQKSKRERFPEASCRAPEFHMHRD-------ESVYVPHALAFRRSYSSKKT 2019

  Fly  2281 I--EKLFSHFSDEMLVNVEFDSNDELVGITPRATLVSRNTEDRDYLDKLESLERDEETFQPVVGE 2343
            .  |:|.:..:..:.......:..|.:....||.::.|.      |:::|..:|..|. :.|..|
 Frog  2020 YTDEELSAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQ------LEQVEEKQRQLEE-RGVAVE 2077

  Fly  2344 KFIQ-------ENVQDEVDGLHF-----PSRPQRRPKS---------SSSSSEPSLPVAPQRL-- 2385
            |.::       |:...::..||.     ...|:|||.|         .....:|.|.....||  
 Frog  2078 KALRGEADYWGESYYSDLIDLHLGVDPVAGTPRRRPLSFCPCCAHEGMGKKDDPKLMQEWFRLVQ 2142

  Fly  2386 -KKKLSKLDPEDMPPSVQDLLQQVYQKNIQPELVEVIPVEG----KQTLRFPSMLAEEDVDEVDH 2445
             |..|.:.:.|.| ...::|..:..|..:|.||.|.:.||.    :|.|.....:..|.:|.|:.
 Frog  2143 EKNALVRYESELM-IFARELELEDRQSRLQQELRERMAVEDQLKTEQELTDEKKILNEMLDVVEQ 2206

  Fly  2446 SKEGIKKIETAPEEVRKVTEPEDVARVIPS 2475
            ....:..:|  .:.:|:..|.:|:..|:.|
 Frog  2207 RDALVALLE--EQRLREKEEDKDLEEVMLS 2234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MicalNP_001247015.1 MDR <114..>160 CDD:302572 31/45 (69%)
CH 563..>629 CDD:294029 18/65 (28%)
LIM_Mical 1097..1153 CDD:188823 27/55 (49%)
Ehrlichia_rpt <2081..2479 CDD:118064 79/426 (19%)
DUF3585 4592..4705 CDD:288945
mical3XP_031754432.1 UbiH 87..>226 CDD:357568 97/138 (70%)
CH_MICAL3 514..624 CDD:409100 33/126 (26%)
LIM_Mical 904..958 CDD:188823 27/55 (49%)
PHA03247 1222..>1479 CDD:223021 67/330 (20%)
Herpes_BLLF1 <1358..1622 CDD:282904 78/338 (23%)
DUF3585 2055..2220 CDD:403377 38/174 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 477 1.000 Domainoid score I428
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001313
OrthoInspector 1 1.000 - - otm48605
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4434
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.910

Return to query results.
Submit another query.