Protein Alignment Spn85F and SERPINB11

DIOPT Version :10

• Sequence 1: NP_649965.2
• Gene: Spn85F / 41221
• FlyBaseID: FBgn0037772
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_536723.2
• Gene: SERPINB11 / 89778
• HGNCID: 14221
• Length: 392
• Species: Homo sapiens
• Alignment Length: 221
• Identity: 57/221 - (25%)
• Similarity: 98/221 - (44%)
• Gaps: 50/221 - (22%)

  Fly   433 EAAEGKSNYNTDVISHVFYLGNQQVVHTTFKVYNAVLYYKYFEHLKMSVLELELDTPEYNLMILL 497
            :.:|||:    ..:..::.:|       |||:       .:.:..:|.||||.....:.:::|||
Human   203 QLSEGKN----VTVEMMYQIG-------TFKL-------AFVKEPQMQVLELPYVNNKLSMIILL 249

  Fly   498 PDYHTDIVAAAASLKLGPTLRLMRKQLK--------------PRWVQAIIPDFKLHGTMFLTNDL 548
            |      |..|       .|:.:.|||.              .|.|:..:|.|||.....|.:.|
Human   250 P------VGIA-------NLKQIEKQLNSGTFHEWTSSSNMMEREVEVHLPRFKLETKYELNSLL 301

  Fly   549 QNMGICDVFEPNRADFRPMTEEKGVYV-RHIEQS-IDVTIR-THPINQLKRNYGAQSKPI--QIS 608
            :::|:.|:|...:||...|:..||:|: :.|.:| :||:.. |........:...:|.|:  |..
Human   302 KSLGVTDLFNQVKADLSGMSPTKGLYLSKAIHKSYLDVSEEGTEAAAATGDSIAVKSLPMRAQFK 366

  Fly   609 VNHPFLFFIVDRDLDVAVMSGRILNP 634
            .||||||||.....:..:..|::.:|
Human   367 ANHPFLFFIRHTHTNTILFCGKLASP 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn85F	NP_649965.2	serpin	72..>174	CDD:476815
		Serpin	<450..634	CDD:459662	53/202 (26%)
SERPINB11	NP_536723.2	serpinB11_epipin	1..392	CDD:381036	56/219 (26%)
		RCL. /evidence=ECO:0000250	341..365		3/23 (13%)