Protein Alignment Spn85F and AGT

DIOPT Version :10

• Sequence 1: NP_649965.2
• Gene: Spn85F / 41221
• FlyBaseID: FBgn0037772
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001369746.2
• Gene: AGT / 183
• HGNCID: 333
• Length: 476
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 132/669 - (19%)
• Similarity: 206/669 - (30%)
• Gaps: 238/669 - (35%)

  Fly     2 AGLVLLFTWLLVHLLQVDAHYIQ----IDHEEFRA-------SGFP-HPHFPPPPL----TPLDH 50
            |.::.|..|  ..|...|..||.    :.|.|...       :|.| .|.|.|.|:    :|:|.
Human    10 ATILCLLAW--AGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDE 72

  Fly    51 L----PQVLAAKELTPAE----VMVD-LTNDLTHRLLHYHSIL---NRNNFAFSPTALVSVLVAL 103
            .    ..||.|.:|...:    .||. |.|.|..|:...||.|   .......||||:...|.:|
Human    73 KALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASL 137

  Fly   104 FEGSAGNTAEELRHVLQLPNNRDVTRVGYRDIHRRLRTYFFGSDNPLKGLSLNKGNVTVLKDFET 168
            :.|:..:||:.|:.:|.:| .:|.......|.|:.|...     ..::||.:.:|..
Human   138 YLGALDHTADRLQAILGVP-WKDKNCTSRLDAHKVLSAL-----QAVQGLLVAQGRA-------- 188

  Fly   169 VLMFYGYDLSVDMLSSTPANLTSDAELVNTTMASNTTTMEMDAETTTSKDAESTTEEPATTTTEP 233
                                 .|.|:|:.:|:....|.                   |.....:|
Human   189 ---------------------DSQAQLLLSTVVGVFTA-------------------PGLHLKQP 213

  Fly   234 PATTTAEPPTTTTETPAETEATTEAPAATSGEEEAAEPAGEDEAAELVSAFVAEEDSEPLLRIQK 298
            .....|  ..|....|...:.|....||...:.......|......|:.|.|   ||........
Human   214 FVQGLA--LYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASV---DSTLAFNTYV 273

  Fly   299 ARVSRLPTSKLQAPLKHSNPITPKPIYLPSARTVAMPMPMMARQVAERKPPGTRQVISIIAPSVQ 363
            ....::....|.|        .|:..::.::.:|::||         ....||.|..|.|..
Human   274 HFQGKMKGFSLLA--------EPQEFWVDNSTSVSVPM---------LSGMGTFQHWSDIQD--- 318

  Fly   364 PANISVTRKTKTARYKRHAIPAYKDLDANLFLTLFNPHTHVPHHPLHFPPPVPAAFAPITNDFEP 428
              |.|||:           :|    ...:..|.|..||
Human   319 --NFSVTQ-----------VP----FTESACLLLIQPH--------------------------- 339

  Fly   429 HYIGEAAEGKSNYNTDVISHVFYLGNQQVVHTTFKVYNAVLYYKYFEHLKMSVLELELDTPEYNL 493
                        |.:|:         .:|...||: .|::.:.|     |:|...:.|..|:
Human   340 ------------YASDL---------DKVEGLTFQ-QNSLNWMK-----KLSPRTIHLTMPQ--- 374

  Fly   494 MILLPDYHTDIVAAAASLK--LGPTLRLMRKQLKPRWVQAIIPDFKLHGTMFLTNDLQNMG--IC 554
            ::|...|....:.|.|.|.  |...|.|.:                      |:||...:|  :.
Human   375 LVLQGSYDLQDLLAQAELPAILHTELNLQK----------------------LSNDRIRVGEVLN 417

  Fly   555 DVFEPNRADFRPMTEEKGVYVRHIEQSIDVTIRTHPINQLKRNYGAQSKP--IQISVNHPFLFFI 617
            .:|....||.|..||.                 |..:|          ||  :::::|.||||.:
Human   418 SIFFELEADEREPTES-----------------TQQLN----------KPEVLEVTLNRPFLFAV 455

  Fly   618 VDRDLDVAVMSGRILNPLN 636
            .|:........||:.|||:
Human   456 YDQSATALHFLGRVANPLS 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn85F	NP_649965.2	serpin	72..>174	CDD:476815	24/104 (23%)
		Serpin	<450..634	CDD:459662	39/189 (21%)
AGT	NP_001369746.2	serpinA8_AGT	28..474	CDD:381010	126/647 (19%)