Protein Alignment MAN2A2 and LManI

DIOPT Version :9

• Sequence 1: NP_001307906.1
• Gene: MAN2A2 / 4122
• HGNCID: 6825
• Length: 1175
• Species: Homo sapiens
• Sequence 2: NP_001260350.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Alignment Length: 1096
• Identity: 289/1096 - (26%)
• Similarity: 462/1096 - (42%)
• Gaps: 247/1096 - (22%)

Human   166 LQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222
            :.|.:|||||:|.||:||.|:||...        .|:||:::|.:|.:|..|||:..|..|||||
  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66

Human   223 WDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLG--ATPRSG 285
            :.......:.||::||..|:||.|.|.|.|.|||..||.:::||...|.::|:...|  ..|..|
  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131

Human   286 WAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMP 350
            |.:||||:|..|..:..:.........|:.|..||.......:|.:| |:.:|..:::||..|:
  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIW-QSSESLKNSNIFTGML- 194

Human   351 FYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEA---NVAERAALLLDQYRKKSQ 412
            :..|..|      |..|  ||        |||  :..|....|:   ||..|.:..:|..:..|:
  Fly   195 YNHYSAP------PGFC--FD--------INC--EDAPIIDGESYDNNVDARVSEFIDYVKNMSK 241

Human   413 LFRSNVLLVPLGDDFRYDKPQEWDA--QFFNYQRLFDFFNSRPNL--HVQAQFGTLSDYFDALY- 472
            .:||..::||:||||:|:     ||  .|.|..:|..:.|.|.:.  .|...:.|.|.|...|:
  Fly   242 SYRSTHIMVPMGDDFQYE-----DAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQ 301

Human   473 -KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAA 536
             |:|          :|..:.|||.|:.....|||||:||||..|...|......:..:.|..||
  Fly   302 LKQT----------WPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLA- 355

Human   537 AHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLV---NLKQV 598
                  .|:|.....|...|::|   :|:.|||||:|||.|:||..||...|.:::|   |..:.
  Fly   356 ------NLSGTQYSEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARD 411

Human   599 IIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQERFSM 663
            .:.:...|..|:.|:        .|:::   :|..|..:.|...:     .|.|.|||.......
  Fly   412 ALRSLTNLTSGEFES--------CLELN---ISVCAFTQDTANNV-----IVTLVNPLAHSSTQY 460

Human   664 VSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQLQLGLDG-- 726
            |.:...:....|..|:|:.:          .:|.||..:||......|......|..:..:|.
  Fly   461 VRVPAKNENYIVTDEKGREV----------FSEVVPVPWQVLALEHRPNDTQHELVFEASVDKIA 515

Human   727 ---HRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKSIRRVD 788
               .|.|||...|.....|..|.|.:           .:..:....:::.|...||.||:::.
  Fly   516 NFLIRVLPSPKNIAEDQVQFPVERSQ-----------DELTVETSLVKLTFDTTTGGLKTVKM-- 567

Human   789 EEHEQQVDMQVLVY-GTR----TSKDK-SGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAY 847
            ....:.:.....:| |.|    .||:: ||||:|.|.|:.:  :......|....|....||
  Fly   568 NGFTENIQQTFGIYKGYRGNNGESKNRSSGAYVFRPYGDIE--IVNNKVELSFYNGTKVKEV--- 627

Human   848 YEHIH----QAVRLYNLPGVEGLSLDISSL--------VDIRDYVNKELALHIHTDIDSQGIFFT 900
            ::|::    |.:|:|.         |::.:        :...|.|.||:.....::|.|:|.|:|
  Fly   628 HQHVNEWISQVIRIYE---------DVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYT 683

Human   901 DLNGFQVQPRRYLKK---LP-----LQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLE 957
            |.||.::..|...::   .|     :..|:||:.....:||.:||:||...:|.|.:|||||:||
  Fly   684 DSNGREILERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELE 748

Human   958 VILDRRLMQDDNRGLGQGLKDNKRTCN---RFRLLLERRTVGSEPDFFSKLAAMFRGLIFHSSRS 1019
            ::|.|||:.||..|:|:.|.:.:....   |.::.|....|..:|:         :.|:.|.
  Fly   749 LMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILDAVDGKPN---------QRLLQHQ--- 801

Human  1020 GNREVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRT 1084
                 .|.|...:.|..:.:.|:.                    |:..|....:|....||:|.
  Fly   802 -----LDQHFWKFFSKSNGVASVN--------------------RNMIPDFFGIPESVELLSLE- 840

Human  1085 LQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNC--------------TTSQGKVAL------- 1128
                    |.::..:::..:.|:  .|...:.||.              ||..|.:.|
  Fly   841 --------PYSKDQILIRLENFN--TEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRFK 895

Human  1129 ------GSLFHGLDVVFLQPTSLTLLYPLASP--SNST------DVYLEPMEIATF 1170
                  ||:          |:|:...:...:|  :|||      .|.|.||:|.||
  Fly   896 FAQDGTGSI----------PSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRTF 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN2A2	NP_001307906.1	PLN02701	136..1174	CDD:178304	289/1096 (26%)
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	100/298 (34%)
		Alpha-mann_mid	323..398	CDD:286360	33/84 (39%)
		Glyco_hydro_38C	536..941	CDD:285047	107/489 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810