Protein Alignment Art4 and PRMT9

DIOPT Version :9

• Sequence 1: NP_001262445.1
• Gene: Art4 / 41219
• FlyBaseID: FBgn0037770
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_612373.2
• Gene: PRMT9 / 90826
• HGNCID: 25099
• Length: 845
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 151/669 - (22%)
• Similarity: 243/669 - (36%)
• Gaps: 223/669 - (33%)

  Fly     1 MSSLRPEEARKLATAASVS--------PLSNCQFC-GV-----------VISSIADEQKLEFTNK 45
            ||:.||...|.....|..:        .|.:.:.| ||           ::.|:|.|.|
Human     1 MSNSRPRSRRDAGGGAGAAGRDELVSRSLQSAEHCLGVQDFGTAYAHYLLVLSLAPELK------ 59

  Fly    46 YKGSCTLLCSYDSQGVVLRVVSDDDRSHVLKE------YMIAADTDAAQ-----MGRRSYAVSLD 99
                                       |.:||      :..|.:.||..     :|....|:.|.
Human    60 ---------------------------HDVKETFQYTLFRWAEELDALSRIQDLLGCYEQALELF 97

  Fly   100 ADNLVLRFASEQDQQLFR------------KVVENVKHLRPKSVFSQRTEESSASQYFQFYGYLS 152
            .|:.|:  .:...:.|||            |.|:    |.|.  ||...|     .:::...:|.
Human    98 PDDEVI--CNSMGEHLFRMGFRDEAAGYFHKAVK----LNPD--FSDAKE-----NFYRVANWLV 149

  Fly   153 QQQN--MMQDYVRTSTYQRAILGNAVDFQDKIVLDVGAGSGILSFFAVQAGAAKVYAIEAS-NMA 214
            ::.:  |:.|..|.:.|..|| ..||....|.|||:|||:||||.||.:|||..|||.|.| .|.
Human   150 ERWHFIMLNDTKRNTIYNAAI-QKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMY 213

  Fly   215 QYAQQLVESNNVQHKISVIPGKIEEIE----LPEKVDVIISEPMGYMLYNERMLETYLHARKWLK 275
            :.|..:|.:|.::..|.::..|..:||    :||:|.::::|.:...|:.|.::|:.:||.:.|.
Human   214 ELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLL 278

  Fly   276 PQGKMYPTHGDLHIAPFSDESLYSEQYNK----ANFWYQSAFHGVDLTTLHKEGMKEY------- 329
            .|.|   |.|         ||...|:|.|    :...:..|....::...|:.|:|:.
Human   279 LQPK---TKG---------ESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPT 331

  Fly   330 ---FRQPI---VDT-------------------------FDIRICMAKSVRHVCDFLNDKEDDLH 363
               |:.|.   |||                         |:|......:::.:......|.|.
Human   332 NVKFQSPAYSSVDTEETIEPYTTEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDK-- 394

  Fly   364 LISIPLEFHILQTGICHGLAFWFDVEFSGSSQNVWLSTSPTAPLTHW----YQVRCLLPMPIFIK 424
             |.||    :::.||...:..||.::......   |||||:.. |.|    |.|:.|  ...:||
Human   395 -IGIP----VIKEGILDAIMVWFVLQLDDEHS---LSTSPSEE-TCWEQAVYPVQDL--ADYWIK 448

  Fly   425 QGQTLTGRVLLEANRRQSY-----------DVTIDL----------------------------- 449
            .|.    .|::|.:.:..|           :..:|:
Human   449 PGD----HVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTS 509

  Fly   450 ---HIEGTLISSSNTLDLKN--PYFRYTGAPVQAPPGTSTQSPSEQYWTQVDTQGSRNSSSMLNG 509
               .:|.|.|..|..:.|.|  ||  :.|..:......|:.:|.:.|.| :||......||....
Human   510 KPDAVEQTCILESTEIALLNNIPY--HEGFKMAMSKVLSSLTPEKLYQT-MDTHCQNEMSSGTGQ 571

  Fly   510 GISVNGIGEG---MDITHG 525
            ..:|..|.|.   :|::.|
Human   572 SNTVQNILEPFYVLDVSEG 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	26/144 (18%)
		PRMT5	53..430	CDD:282971	111/452 (25%)
		AdoMet_MTases	183..281	CDD:100107	40/102 (39%)
PRMT9	NP_612373.2	TPR 1	25..58		6/32 (19%)
		TPR	<39..144	CDD:223533	25/150 (17%)
		TPR 2	67..100		6/32 (19%)
		TPR repeat	68..95	CDD:276809	5/26 (19%)
		TPR repeat	100..130	CDD:276809	6/35 (17%)
		TPR 3	101..134		8/40 (20%)
		AdoMet_MTases	148..>303	CDD:327401	57/167 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810