DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art4 and Prmt3

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_446009.1	Gene:	Prmt3 / 89820	RGDID:	620413	Length:	528	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	130/401 - (32%)
Similarity:	209/401 - (52%)	Gaps:	37/401 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 IAADTDAAQMGRRSYAVSLDADNLVLRFASEQDQQLFRKVVEN-VKHLRPKSVFSQRT----EES 139
            ::.:|.|.:..:...|.:|.|:..:.|  :.:|.|..::..:: |.::..::..|..|    :|.
  Rat   150 LSENTSAVEKLKLMEARALSAEAALAR--AREDLQKMKQFAQDFVMNVDVRTCSSTTTIADLQED 212

  Fly   140 SASQYFQFYGYLSQQQNMMQDYVRTSTYQRAILGNAVDFQDKIVLDVGAGSGILSFFAVQAGAAK 204
            ....||..||:....:.|::|.|||.:|:..|..|...|:||:|||||.|:||||.||.:|||.|
  Rat   213 EDGVYFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKK 277

  Fly   205 VYAIEASNMAQYAQQLVESNNVQHKISVIPGKIEEIELP-EKVDVIISEPMGYMLYNERMLETYL 268
            |.|::.|.:...|..::..|.::..|.:|.|||||:.|| |||||||||.|||.|..|.||::.|
  Rat   278 VIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMGYFLLFESMLDSVL 342

  Fly   269 HAR-KWLKPQGKMYPTHGDLHIAPFSDESLYSEQYNKANFWYQSAFHGVDLTTLHKEGMKEYFRQ 332
            :|: |:|...|.:||....:.:...||.|.:::   :..||  ...:|.:::.:.|..:.|
  Rat   343 YAKSKYLAKGGSVYPDICTISLVAVSDVSKHAD---RIAFW--DDVYGFNMSCMKKAVIPE---- 398

  Fly   333 PIVDTFDIRICMAKSVRHVCDFLNDKEDDLHLISI-PLEF------HILQTGICHGLAFWFDVEF 390
            .:|:..|.:..::..    ||.   |..|.|..|| .|||      ...:|.:|..:|.:||:.|
  Rat   399 AVVEVVDHKTLISDP----CDI---KHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAGYFDIYF 456

  Fly   391 SGSSQN-VWLSTSPTAPLTHWYQVRCLLPMPIFIKQGQTLTGRVLLEANRRQSYDVTIDLHIEGT 454
            ..:..| |..||.|.:..|||.|...||..|..:|.|:.|.|::.:..|::....:.:.|    |
  Rat   457 EKNCHNRVVFSTGPQSTKTHWKQTIFLLEKPFPVKAGEALKGKITVHKNKKDPRSLIVTL----T 517

  Fly   455 LISSSNTLDLK 465
            |.||:.|..|:
  Rat   518 LNSSTQTYSLQ 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	9/54 (17%)
		PRMT5	53..430	CDD:282971	120/364 (33%)
		AdoMet_MTases	183..281	CDD:100107	51/99 (52%)
Prmt3	NP_446009.1	zf-C2H2_2	48..>97	CDD:289522
Prmt3	NP_446009.1	AdoMet_MTases	256..356	CDD:100107	51/99 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820