DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art4 and PRMT4A

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_199713.2	Gene:	PRMT4A / 834961	AraportID:	AT5G49020	Length:	528	Species:	Arabidopsis thaliana

Alignment Length:	532	Identity:	217/532 - (40%)
Similarity:	289/532 - (54%)	Gaps:	83/532 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLRPEEARKLATAASV-SPLSNCQFCGVV--ISSIADEQKLEF---------------TNKYK-G 48
            ||..::...||:...: ||.|:.....||  .|.:.:.::|.|               |..:| |
plant     5 SLNKQQEFTLASVTDLTSPSSSLSSSPVVATFSCVNEVKELRFQESKSSDGFSFDLSSTQLFKLG 69

  Fly    49 SCTLLCSYD------------SQGVVLRVVSDDDRSHVLKEYMIAADTDAAQMGR---RSYAVSL 98
            .....|..|            |:|||::...:.|.......:......||.:.|.   ....||.
plant    70 PLQFTCVSDGSISSAKEKSSFSRGVVIKFRDEKDSKEFCDSFEECKKDDAVKQGSALPNGTVVSA 134

  Fly    99 DADNLVLRFASEQDQQLFRKVVENVKHLRPKSVFSQRTEESSASQYFQFYGYLSQQQNMMQDYVR 163
            :                             ||.|..:.|.:||..||.:||.|..||||:|||||
plant   135 N-----------------------------KSKFDDKIEAASAKMYFHYYGQLLHQQNMLQDYVR 170

  Fly   164 TSTYQRAILGNAVDFQDKIVLDVGAGSGILSFFAVQAGAAKVYAIEASNMAQYAQQLVESNN-VQ 227
            |.||..|::.|..||..::|:||||||||||.||..|||..|||:|||.||:||::|:..|. :.
plant   171 TGTYHAAVMENRSDFSGRVVVDVGAGSGILSMFAALAGAKHVYAVEASEMAEYARKLIAGNPLLA 235

  Fly   228 HKISVIPGKIEEIELPEKVDVIISEPMGYMLYNERMLETYLHAR-KWLKPQGKMYPTHGDLHIAP 291
            .:|:||.||||:||||||.||:||||||.:|.||||||||:.|| ::|.|.|||:||.|.:|:||
plant   236 ERITVIKGKIEDIELPEKADVLISEPMGTLLVNERMLETYVIARDRFLSPNGKMFPTVGRIHMAP 300

  Fly   292 FSDESLYSEQYNKANFWYQSAFHGVDLTTLHKEGMKEYFRQPIVDTFDIRICMAKSVRHVCDFLN 356
            |:||.|:.|..|||.||.|..::|||||.|:....:.||.||:||.||.|:.:|.|:.||.||..
plant   301 FADEFLFVEMANKALFWQQQNYYGVDLTPLYVSAHQGYFSQPVVDAFDPRLLVAPSMFHVIDFTM 365

  Fly   357 DKEDDLHLISIPLEFHILQTGIC---HGLAFWFDVEFSGSSQNVWLSTSPTAPLTHWYQVRCLLP 418
            ..|:..:.|.|||:|   ...:|   ||||.||||.|.||:...|.:|:|.||.|||||:||:|.
plant   366 MTEEQFYEIDIPLKF---TASVCTRIHGLACWFDVLFDGSTVQRWFTTAPGAPTTHWYQIRCVLS 427

  Fly   419 MPIFIKQGQTLTGRVLLEANRRQSYDVTIDLHIE---------GTLISSSNTLDLKNPYFRYTGA 474
            .||.:..||.:|||:.|.|:..|||.:.:.|..:         |.|.:||..||||.||:|.:..
plant   428 QPIHVMAGQEITGRLHLIAHSAQSYTINLTLSAKMWGPGANQGGILQTSSCKLDLKEPYYRMSQP 492

  Fly   475 ---PVQAPPGTS 483
               |.|.||..|
plant   493 QVYPTQEPPAQS 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	23/142 (16%)
		PRMT5	53..430	CDD:282971	177/396 (45%)
		AdoMet_MTases	183..281	CDD:100107	64/99 (65%)
PRMT4A	NP_199713.2	SmtA	140..400	CDD:223574	142/262 (54%)
PRMT4A	NP_199713.2	AdoMet_MTases	160..>300	CDD:302624	85/139 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	225	1.000	Domainoid score	I686
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10990
Inparanoid	1	1.050	365	1.000	Inparanoid score	I577
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0004110
OrthoInspector	1	1.000	-	-		otm3528
orthoMCL	1	0.900	-	-		OOG6_104007
Panther	1	1.100	-	-	O	PTHR11006
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2851
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830