Protein Alignment Art4 and Carm1

DIOPT Version :10

• Sequence 1: NP_649963.1
• Gene: Art4 / 41219
• FlyBaseID: FBgn0037770
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_067506.2
• Gene: Carm1 / 59035
• MGIID: 1913208
• Length: 608
• Species: Mus musculus
• Alignment Length: 472
• Identity: 272/472 - (57%)
• Similarity: 348/472 - (73%)
• Gaps: 20/472 - (4%)

  Fly    57 DSQGVVLRVVSDDDRSH----VLKEYMIAADTDAAQMGRRSYAVSLDADNLVLRFASEQDQQLFR 117
            |:.|:.|       .||    |.| ..::.:|:.:::||:|:.::|..::::::||:..|...|.
Mouse    66 DAAGIAL-------YSHEDVCVFK-CSVSRETECSRVGRQSFIITLGCNSVLIQFATPHDFCSFY 122

  Fly   118 KVVENVK-HLRPKSVFSQRTEESSASQYFQFYGYLSQQQNMMQDYVRTSTYQRAILGNAVDFQDK 181
            .:::..: |...:||||:|||||||.||||||||||||||||||||||.|||||||.|..||:||
Mouse   123 NILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDK 187

  Fly   182 IVLDVGAGSGILSFFAVQAGAAKVYAIEASNMAQYAQQLVESNNVQHKISVIPGKIEEIELPEKV 246
            ||||||.|||||||||.||||.|:||:|||.|||:|:.||:|||:..:|.|||||:||:.|||:|
Mouse   188 IVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQV 252

  Fly   247 DVIISEPMGYMLYNERMLETYLHARKWLKPQGKMYPTHGDLHIAPFSDESLYSEQYNKANFWYQS 311
            |:||||||||||:||||||:||||:|:|||.|.|:||.||:|:|||:||.||.||:.|||||||.
Mouse   253 DIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQP 317

  Fly   312 AFHGVDLTTLHKEGMKEYFRQPIVDTFDIRICMAKSVRHVCDFLNDKEDDLHLISIPLEFHILQT 376
            :||||||:.|....:.||||||:||||||||.|||||::..:||..||.|||.|.||.:||:|.:
Mouse   318 SFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHS 382

  Fly   377 GICHGLAFWFDVEFSGSSQNVWLSTSPTAPLTHWYQVRCLLPMPIFIKQGQTLTGRVLLEANRRQ 441
            |:.|||||||||.|.||...|||||:||.|||||||||||...|:|.|.|.||:|..||.||:||
Mouse   383 GLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQ 447

  Fly   442 SYDVTIDLHIEGTLISSSNTLDLKNPYFRYTGAPVQAPPGTSTQSPSEQYWTQVDTQGSRNSSSM 506
            |||::|...::.|...|||.||||||:|||||.....|||:...||||..|       :..|:..
Mouse   448 SYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMW-------NTGSTYN 505

  Fly   507 LNGGISVNGIGEGMDIT 523
            |:.|::|.|:....|::
Mouse   506 LSSGVAVAGMPTAYDLS 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_649963.1	PH-like	24..134	CDD:473070	20/81 (25%)
		COG4076	154..341	CDD:443253	135/186 (73%)
Carm1	NP_067506.2	Interaction with C9orf72. /evidence=ECO:0000269|PubMed:30366907	28..139		19/80 (24%)
		CARM1	35..139	CDD:402914	19/80 (24%)
		COG4076	160..347	CDD:443253	135/186 (73%)
		Required for nuclear translocation. /evidence=ECO:0000269|PubMed:30366907	347..380		19/32 (59%)
		Transactivation domain. /evidence=ECO:0000269|PubMed:11701890	500..608		6/23 (26%)