DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art4 and prmt8b

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_005164711.1	Gene:	prmt8b / 564110	ZFINID:	ZDB-GENE-030131-7791	Length:	420	Species:	Danio rerio

Alignment Length:	426	Identity:	133/426 - (31%)
Similarity:	210/426 - (49%)	Gaps:	46/426 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RSHVLKEYMIAADTDAAQMGRRSYAVSLDADNLVLRFASEQDQQ--LFRKVVENVKHLRPKSVFS 133
            |..:|:..|..|::...|..::...........:....|.|..|  ...|.|.:|.|:.|....:
Zfish     8 RCLLLRRKMAEAESTEQQQQQKHKQPQHQQQQSISSIPSSQSLQPSPLPKPVTSVHHVPPHPPHT 72

  Fly   134 QRT-------------------EESSASQYFQFYGYLSQQQNMMQDYVRTSTYQRAILGNAVDFQ 179
            ...                   |.:|...||..|.:....:.|::|.|||.||:.::..|...|:
Zfish    73 PHVSALSACPGRGKMAKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHIFK 137

  Fly   180 DKIVLDVGAGSGILSFFAVQAGAAKVYAIEASNMAQYAQQLVESNNVQHKISVIPGKIEEIELP- 243
            ||||||||:|:||||.||.:|||..||.||.|::::|::::::||::...|:::.||:||.|||
Zfish   138 DKIVLDVGSGTGILSMFAAKAGAKHVYGIECSSISEYSEKIIKSNHLDSVITILKGKVEETELPV 202

  Fly   244 EKVDVIISEPMGYMLYNERMLETYLHAR-KWLKPQGKMYPTHGDLHIAPFSDESLYSEQYNKANF 307
            ::||:||||.|||.|:.|.||.|.::|| |||||.|.|:|....|::....|     .||.....
Zfish   203 DQVDIIISEWMGYCLFYESMLNTVIYARDKWLKPGGFMFPDRATLYVVAIED-----RQYKDFKI 262

  Fly   308 -WYQSAFHGVDLTTLHKEGMKEYFRQPIVDTFD-----IRICMAKSVRHVCDFLNDKEDDLHLIS 366
             |:::.: |.|:|.:....|.|    |:||..|     ...|:.|.|    |....|.:||...|
Zfish   263 HWWENVY-GFDMTCIRNVAMME----PLVDIVDPKQVVTNSCLVKEV----DIYTVKTEDLSFTS 318

  Fly   367 IPLEFHILQTGICHGLAFWFDVEFSGSSQNVWLSTSPTAPLTHWYQVRCLLPMPIFIKQGQTLTG 431
             .....|.:....|.|..:|::||:...:....||:|.||.|||.|....|...:.:::|:.:.|
Zfish   319 -AFCLQIQRNDYVHALVTYFNIEFTKCHKKTGFSTAPDAPSTHWKQTVFYLEDYLTVRRGEEILG 382

  Fly   432 RVLL--EANRRQSYDVTIDLHIEGTLISSSNTLDLK 465
            .:.:  ..|..:..|.|.:|..:|.|..::.:.|.|
Zfish   383 SITVRPNENNERDLDFTFELDFKGQLCDAAISHDYK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	13/64 (20%)
		PRMT5	53..430	CDD:282971	124/387 (32%)
		AdoMet_MTases	183..281	CDD:100107	53/99 (54%)
prmt8b	XP_005164711.1	AdoMet_MTases	141..241	CDD:100107	53/99 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820