DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art4 and PRMT8

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_062828.3	Gene:	PRMT8 / 56341	HGNCID:	5188	Length:	394	Species:	Homo sapiens

Alignment Length:	352	Identity:	125/352 - (35%)
Similarity:	196/352 - (55%)	Gaps:	32/352 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 KHLRPKSVFSQRTEESSASQYFQFYGYLSQQQNMMQDYVRTSTYQRAILGNAVDFQDKIVLDVGA 188
            |.|.|:       |.:|...||..|.:....:.|::|.|||.||:.::..|...|:||:|||||:
Human    63 KLLNPE-------EMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS 120

  Fly   189 GSGILSFFAVQAGAAKVYAIEASNMAQYAQQLVESNNVQHKISVIPGKIEEIELP-EKVDVIISE 252
            |:||||.||.:|||.||:.||.|:::.|:::::::|::.:.|::..||:||:||| ||||:||||
Human   121 GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISE 185

  Fly   253 PMGYMLYNERMLETYLHAR-KWLKPQGKMYPTHGDLHIAPFSDESLYSEQYNKANF-WYQSAFHG 315
            .|||.|:.|.||.|.:.|| |||||.|.|:|....|::....|     .||..... |:::.: |
Human   186 WMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIED-----RQYKDFKIHWWENVY-G 244

  Fly   316 VDLTTLHKEGMKEYFRQPIVDTFD-----IRICMAKSVRHVCDFLNDKEDDLHLISIPLEFHILQ 375
            .|:|.:....|||    |:||..|     ...|:.|.|    |....|.::|...| .....|.:
Human   245 FDMTCIRDVAMKE----PLVDIVDPKQVVTNACLIKEV----DIYTVKTEELSFTS-AFCLQIQR 300

  Fly   376 TGICHGLAFWFDVEFSGSSQNVWLSTSPTAPLTHWYQVRCLLPMPIFIKQGQTLTGRVLLEANRR 440
            ....|.|..:|::||:...:.:..||:|.||.|||.|....|...:.:::|:.:.|.:.::.|.:
Human   301 NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAK 365

  Fly   441 --QSYDVTIDLHIEGTLISSSNTLDLK 465
              :..|.|:||..:|.|..:|.:.|.|
Human   366 NVRDLDFTVDLDFKGQLCETSVSNDYK 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	3/9 (33%)
		PRMT5	53..430	CDD:282971	114/313 (36%)
		AdoMet_MTases	183..281	CDD:100107	54/99 (55%)
PRMT8	NP_062828.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..40
		SH3-binding 1. /evidence=ECO:0000269\|PubMed:17925405	29..42
		SH3-binding 2. /evidence=ECO:0000269\|PubMed:17925405	53..58
		AdoMet_MTases	115..215	CDD:100107	54/99 (55%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000305\|PubMed:26529540, ECO:0000305\|PubMed:26876602, ECO:0007744\|PDB:4X41, ECO:0007744\|PDB:5DST	119..122		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820