DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art4 and prmt3

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001017655.1	Gene:	prmt3 / 550348	ZFINID:	ZDB-GENE-041105-1	Length:	512	Species:	Danio rerio

Alignment Length:	493	Identity:	145/493 - (29%)
Similarity:	224/493 - (45%)	Gaps:	90/493 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 CQFC------------------GVVISSIADEQKLE-----------FTNKYKGSCTLLCS---- 55
            |.||                  ||.|..:..:.||:           .|.|......||.|
Zfish    39 CLFCDRNLTSVSETFQHCKADHGVDILDLVQKHKLDDYGYIKMINYIRTTKCSAESLLLASDGPL 103

  Fly    56 -YDSQGVVLRVVSDDDRSHVLKEYMIAADTDAAQMGRRSYAVSLDADNLVLRFASE------QDQ 113
             :|....:...:.||....:..|.:..|   :..||..|.|..::.::.|.| |.|      ||.
Zfish   104 PWDGDEYMKPALQDDPLLQIDVEELREA---SGGMGSSSAADQVNVEDRVQR-AEEALARAMQDM 164

  Fly   114 QLFRKVVE------NVKHLRPK---SVFSQRTEESSASQYFQFYGYLSQQQNMMQDYVRTSTYQR 169
            ...:.:.:      :..| .|.   ::...|.:|..|  ||..||:.|..:.|::|.|||.:|:.
Zfish   165 HKLKLLAQGLVLNADTSH-GPTCSGAIAELREDEDEA--YFSSYGHYSIHEEMLKDKVRTESYRD 226

  Fly   170 AILGNAVDFQDKIVLDVGAGSGILSFFAVQAGAAKVYAIEASNMAQYAQQLVESNNVQHKISVIP 234
            .:..|...|:||:|||||.|:||||.||.:|||.||.|::.|.:...|..:|.|||::..|::|.
Zfish   227 FMYRNMDVFKDKVVLDVGCGTGILSMFAAKAGAKKVVAVDQSEIIYQAMDIVRSNNLEDTITLIK 291

  Fly   235 GKIEEIELP-EKVDVIISEPMGYMLYNERMLETYLHAR-KWLKPQGKMYPTHGDLHIAPFSDESL 297
            |:||||:|| ||||:||||.|||.|....||::.|:|| ::|...|.::|....:.:|...|...
Zfish   292 GRIEEIDLPVEKVDIIISEWMGYFLLFGSMLDSVLYARDRYLADDGLVFPDRCSISLAAVGDTQK 356

  Fly   298 YSEQYNKANFWYQSAFHGVDLTTLHK----EGMKEYFR-------QPIVDTFDIRICMAKSVRHV 351
            :::   :..||  ...:|..:|.:.|    |.:.|..:       ..::.|.|   |.:.||..:
Zfish   357 HND---RIAFW--EDVYGFKMTCMKKAVIPEAVVEVLKPETVISESAVIKTID---CGSVSVSEL 413

  Fly   352 CDFLNDKEDDLHLISIPLEFHILQTGICHGLAFWFDVEFSGSSQN-VWLSTSPTAPLTHWYQVRC 415
             :|           |:.....|..:..|..:..:||:.|..|..| |..||:|....|||.|...
Zfish   414 -EF-----------SVDFILKITASSFCTAIVGYFDIFFHKSCGNKVMFSTAPNCTKTHWKQTVF 466

  Fly   416 LLPMPIFIKQGQTLTGRVLLEANRRQSYDVTIDLHIEG 453
            ||..|:.:|.|:.|.|.:.:..||:....:.|.|:|.|
Zfish   467 LLESPVAVKAGEDLPGHISVRKNRKDPRALLITLNIAG 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	30/158 (19%)
		PRMT5	53..430	CDD:282971	126/410 (31%)
		AdoMet_MTases	183..281	CDD:100107	52/99 (53%)
prmt3	NP_001017655.1	zf-C2H2_2	39..>86	CDD:289522	8/46 (17%)
prmt3	NP_001017655.1	Methyltransf_18	236..340	CDD:289607	54/103 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820