DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art4 and carm1

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001003645.1	Gene:	carm1 / 445251	ZFINID:	ZDB-GENE-040724-77	Length:	588	Species:	Danio rerio

Alignment Length:	526	Identity:	281/526 - (53%)
Similarity:	368/526 - (69%)	Gaps:	41/526 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FCGVVISSIAD----------EQKLEFTNKYKGSCTLLCSYDSQGVVLRVVSDDDRSHVLKEYMI 80
            |.||.:.||.|          :|.|....|        .:.|:..::|   |:::.:.|.| ..:
Zfish     6 FSGVRLLSIGDANGDIQRHSEQQPLRLEIK--------MNQDAAQIIL---SNNEETCVFK-CTV 58

  Fly    81 AADTDAAQMGRRSYAVSLDADNLVLRFASEQDQQLFRKVVENVKHLR-PKSVFSQRTEESSASQY 144
            ..:|:.:::|::|:.::|..::::|:|||..|...|..:::..:..: .:||||.|||||||.||
Zfish    59 LRETECSRVGKQSFIITLGCNSVLLQFASPADFSSFYNLLKICRGQKGDRSVFSDRTEESSAVQY 123

  Fly   145 FQFYGYLSQQQNMMQDYVRTSTYQRAILGNAVDFQDKIVLDVGAGSGILSFFAVQAGAAKVYAIE 209
            ||||||||||||||||||||.|||||||.|..||:||:|||||.|||||||||.||||.||||:|
Zfish   124 FQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKVVLDVGCGSGILSFFAAQAGARKVYAVE 188

  Fly   210 ASNMAQYAQQLVESNNVQHKISVIPGKIEEIELPEKVDVIISEPMGYMLYNERMLETYLHARKWL 274
            ||.|||:|:.||.||.:..::.|||||:||:.|||:||:||||||||||:||||||:||||:|:|
Zfish   189 ASTMAQHAEVLVNSNRLSERVVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKFL 253

  Fly   275 KPQGKMYPTHGDLHIAPFSDESLYSEQYNKANFWYQSAFHGVDLTTLHKEGMKEYFRQPIVDTFD 339
            ||.|||:||.||:|:|||:||.||.||:.|||||||.:||||||:.|....:.||||||||||||
Zfish   254 KPSGKMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPIVDTFD 318

  Fly   340 IRICMAKSVRHVCDFLNDKEDDLHLISIPLEFHILQTGICHGLAFWFDVEFSGSSQNVWLSTSPT 404
            |||.|||||::..:||..||:||:.|.||.:||::.:|:.|||||||||.|.||...|||||:||
Zfish   319 IRILMAKSVKYTVNFLEAKEEDLYKIEIPFKFHMMHSGLVHGLAFWFDVAFIGSVMTVWLSTAPT 383

  Fly   405 APLTHWYQVRCLLPMPIFIKQGQTLTGRVLLEANRRQSYDVTIDLHIEGTLISSSNTLDLKNPYF 469
            .||||||||||||..|:|.|.|.|::|..||.||:|||||::|...::.|...|||.||||||:|
Zfish   384 EPLTHWYQVRCLLQSPLFAKAGDTMSGTALLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFF 448

  Fly   470 RYTGAPVQAPPGTSTQSPSEQYWTQVDTQGSRNSSSMLNGGISVNGI-----------GEGMDIT 523
            ||||.....|||:...||||..|   :|.|:.:.|.    |::|:|:           |.|..::
Zfish   449 RYTGTTPAPPPGSHYSSPSENMW---NTGGTYSMSQ----GMAVSGMPTAYDLSTVIGGSGTTVS 506

  Fly   524 HGLMHP 529
            |..:.|
Zfish   507 HNNLIP 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	27/118 (23%)
		PRMT5	53..430	CDD:282971	228/377 (60%)
		AdoMet_MTases	183..281	CDD:100107	71/97 (73%)
carm1	NP_001003645.1	CARM1	8..112	CDD:288395	25/115 (22%)
		PRMT5	<146..409	CDD:282971	179/262 (68%)
		AdoMet_MTases	162..263	CDD:100107	73/100 (73%)
		Transactivation domain. /evidence=ECO:0000250	473..588		10/44 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575181
Domainoid	1	1.000	337	1.000	Domainoid score	I1076
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10990
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1126
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233082at33208
OrthoFinder	1	1.000	-	-		FOG0004110
OrthoInspector	1	1.000	-	-		otm25029
orthoMCL	1	0.900	-	-		OOG6_104007
Panther	1	1.100	-	-	LDO	PTHR11006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4498
SonicParanoid	1	1.000	-	-		X2851
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790