DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art4 and Prmt9

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001178528.1	Gene:	Prmt9 / 291947	RGDID:	1306157	Length:	841	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	112/446 - (25%)
Similarity:	190/446 - (42%)	Gaps:	105/446 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 MGRRSYAVSLDADNLVLRFASEQDQQLFR------------KVVENVKHLRPKSVFSQRTEESSA 141
            :|....|:.|..|:.|:  .:...:.|||            |.|:    |.|.  |:...|
  Rat    87 LGCYEQALELFPDDEVI--CNSMGEHLFRMGFRDEAAGYFHKAVK----LNPD--FNDAKE---- 139

  Fly   142 SQYFQFYGYLSQQQN--MMQDYVRTSTYQRAILGNAVDFQDKIVLDVGAGSGILSFFAVQAGAAK 204
             .:::...:|.::.:  |:.|..|...|..|| ..||....|.|||:|||:||||.||.:|||..
  Rat   140 -NFYRVANWLVERWHFIMLNDTKRNEIYNAAI-QKAVRLGSKTVLDIGAGTGILSMFAKKAGAHS 202

  Fly   205 VYAIEAS-NMAQYAQQLVESNNVQHKISVIPGKIEEIE----LPEKVDVIISEPMGYMLYNERML 264
            |||.|.| .|.:.|..:|.:|.::..|.::..|..::|    :||:|.::::|.:...::.|.::
  Rat   203 VYACELSKTMYELACDVVAANKMEDGIRLLHMKSLDLEIPKHIPERVSLVVTETVDAGVFGEGIV 267

  Fly   265 ETYLHARKW----LKPQ-----------GKMYPTHGDLHIAPFSDESLYSEQYNK---------- 304
            |:.:||  |    |:||           ||:.|  ....|:..:.|.....::::
  Rat   268 ESLIHA--WEHLLLQPQTKGESGSWGKYGKVIP--ASAVISGMAVECAEIRRHHRVSAKDIAGIH 328

  Fly   305 --ANFWYQS-AFHGVD-------LTTLHKEGMKEYFRQPIVDTFDIRICMAKSVRHVCDFLNDKE 359
              .|..:|| |:..||       .||....|:...:| |:.:.|.|......:::.:......|.
  Rat   329 LPTNVRFQSPAYASVDPEETVEPYTTEKMSGIPGGYR-PLTECFQIMKVDFNNLQELKSLATRKP 392

  Fly   360 DDLHLISIPLEFHILQTGICHGLAFWFDVEFSGSSQNVWLSTSPTAPLTHW----YQVRCLLPMP 420
               |.:|:|    .::.|....:..||.::......   |||||:.. |.|    |.|:.|  ..
  Rat   393 ---HSLSVP----AVKEGTLDAIMVWFVLQLDDEHS---LSTSPSEE-TCWEQAVYPVQAL--ED 444

  Fly   421 IFIKQGQTLTGRVLLEANRRQSY----DVTIDLHIE------GTLISSSNTLDLKN 466
            .:|:.|..:|    :||:....|    .::| ||:|      .:...|.:.|.|.|
  Rat   445 YWIQPGDQVT----MEASCHDCYLRIQGISI-LHLEHEMEVIKSFTKSKDLLSLGN 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	13/56 (23%)
		PRMT5	53..430	CDD:282971	100/398 (25%)
		AdoMet_MTases	183..281	CDD:100107	41/117 (35%)
Prmt9	NP_001178528.1	TPR_11	68..132	CDD:290150	11/50 (22%)
		TPR repeat	68..95	CDD:276809	2/7 (29%)
		TPR repeat	100..130	CDD:276809	6/35 (17%)
		AdoMet_MTases	148..>338	CDD:302624	56/194 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810