DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art4 and prmt-7

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_492436.2	Gene:	prmt-7 / 172727	WormBaseID:	WBGene00012298	Length:	647	Species:	Caenorhabditis elegans

Alignment Length:	427	Identity:	91/427 - (21%)
Similarity:	158/427 - (37%)	Gaps:	123/427 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 QDYVRTSTYQRAILGNAV---DFQDKI---------------------VLDVGAGSGILSFFAVQ 199
            :||.......|:..|:.:   |..||.                     |||:|.|:|:||..|.:
Worm    20 EDYDMAQELARSRFGDMILDFDRNDKFLAGLKTTIAEKKHENTDGKVHVLDIGTGTGLLSLMAAR 84

  Fly   200 AGAAKVYAIEA-SNMAQYAQQLVESNNVQHKISVIPGKIEEIEL--PEKVDVIISEPMGYMLYNE 261
            .||.||.|:|. ..|...|:.:..::....||:||..:..::..  ..:.|:|::|.....|..|
Worm    85 EGADKVTALEVFKPMGDCARHITSNSPWSDKITVISERSTDVSQIGGSRADIIVAEVFDTELIGE 149

  Fly   262 RMLETYLHARKWL-KPQGKMYPTHGDLHIAPFSDESLYSEQYNKANFWYQSAFHGVDLTTLHKEG 325
            ..|.|:..|.:.| ||..::.|:.|:::|.|.  ||...:.:|             |:..|:.|.
Worm   150 GALRTFKEALERLAKPGCRVVPSTGNVYIVPV--ESHLLKMFN-------------DIPRLNGEK 199

  Fly   326 MKEYFRQPI------VDTFDIRICMAKSVRHVCDFLND-----KEDDLHLISIPLEFHILQTGIC 379
            .:|    |:      ...||:::...|:  |....|::     |.|..|...|..:...::..:.
Worm   200 DEE----PLGRCSGTAAVFDVQLSEMKT--HEFRELSEPIVAFKFDFEHEEKIIFDESFVREAVA 258

  Fly   380 H------GLAFWFDVEFSGSSQNV------WLSTSPTAPLTHWYQVRCLLPMPIFIKQGQTL--- 429
            |      .|..|:|::...:....      |.:.:..|...||.|....||....::..||.
Worm   259 HSSGTIDALLMWWDIDMDRNGTTFIDMGPKWKNKNNYAWRDHWMQAVYYLPEKKKVEMNQTFEIV 323

  Fly   430 ------------TGRVLLEANRRQSYDVTIDLHIEGTLISSSNTLDLKNPYFRYTGAPVQAPPGT 482
                        .|:     ::.:||.| ..||    .:.|..|:...|..|.
Worm   324 CNHDEFSLWFSNVGK-----DKSRSYCV-CGLH----SMLSRQTVYHVNEMFE------------ 366

  Fly   483 STQSPSEQYWTQVDTQGSRNSSSMLNGGISVNGIGEG 519
                 ::::..:||         .|:.|:.|..:|||
Worm   367 -----NQKFKDEVD---------KLSKGLHVATVGEG 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622
		PRMT5	53..430	CDD:282971	73/336 (22%)
		AdoMet_MTases	183..281	CDD:100107	32/101 (32%)
prmt-7	NP_492436.2	SmtA	19..258	CDD:223574	60/258 (23%)
prmt-7	NP_492436.2	AdoMet_MTases	34..>238	CDD:302624	53/224 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810